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The map label for this gene is ptpA [H]

Identifier: 150003690

GI number: 150003690

Start: 1495287

End: 1497530

Strand: Reverse

Name: ptpA [H]

Synonym: BVU_1121

Alternate gene names: 150003690

Gene position: 1497530-1495287 (Counterclockwise)

Preceding gene: 150003691

Following gene: 150003689

Centisome position: 29.0

GC content: 46.43

Gene sequence:

>2244_bases
ATGAAGGTTGGTAAGTTAGGTTGGCTGGTAGCCATGTTCCTTAGTGGGGGCATGGCTGTCGCTCAAGGTACGGTCGATGA
TTATCGGCGTGCTTATGCATTGAAAGAGAAGTTCAGTGCGGATAAAGTTTTCTATTCCAATGTCAATCCGCAATGGATAG
AGGGTACTCATCAATTCTGGTATGTGCGGAATACTCCGGACGGCTGCCTGTATGTATCTGTAGATGCGGATAAGAAAGCT
AGAAAAGAATTGTTTGATTCTCATCGTCTGGCAAAGGCGTTGGGTGCTGCATCCGGAAAAGAGGTCAAGCCGGAAGCTCT
TGCATTGGGGCGTTTGTCGGTCAGTAAGGGATTGGATACGCTGCGCTTTGTGTTTAATAATCAACGTTGGATGTATGCGT
CCCGGAAAAATCAACTGGTCAATGAAGGTGCGGTTCCTCTCCCTCCCAAGCAAAAGCATTGGATGGAGGTGGATGATGAG
AAGACGGCATCACCGGTTCCGTCTCCTGATGGTAAATGGATCGCATTTATTAAAAATCAGAATATCTATGTAAAGGAGGT
GGCTACCGGAAAAGAAAAGCAACTGAGCTTGGACGGGACACTGGGTAATTATTATTCAGCCTACATCCGCTGGTCACCGG
ACAGTAAGAAGGTGGCTTCCTGCAAGATCCGTCCGGTGGAAAAGCGTTATGTTTATTATGTGGAATCTTCTCCGGCTGAT
CAGCTTCAGCCCAAGCTTCACAAACAGGAGTATGCGAAGCCGGGAGACGAACTTCCTTTTAAAGTGCCCTGCATCTATGA
AGTGGAAAGCGGACGAAGCATTATTCCTTCTACCGAATTGTTCGACCGGCAATATGAAGTATATGGTCCCGAATGGAATC
CCGACAGCCGTGCCGTGACTTTTGAATATAACCAGCGCGGACATCAGGTGTACAGAGTACTTGAATTTTCTGCCGAAACG
GGAAAAGTGCGCCCGTTGGTAGAAGAAACCAGCGATACATATGTGAATTATACCCGTCATTTCCGTCATGACTTAAAAGA
CGGCAAGCAGATGATATGGATGAGTGAGCGTGACAATTGGAATCATCTTTATATGTACAACCGTATTACCGCACAGCCCG
ATTATCAAATTACTAAAGGAGAATGGTATGTACGCGAAGTGCTTCGGGTAGATGAGGATAACCGTCAGATCTATTTCTCG
GCAAATGGTATGGAAGCCGGTGAAGACCCCTATCTCATCCGTTATTACCGCATCGGTTTTGATGGCAAAGGTCTTACCTG
TCTTACTCCCGAAGAAGGGATGCACCGTGCCTGGTTTTCGGGAGATATGAAGTATTTGGTAGATGTTTATTCTATGGTGG
ACAAGGTTCCCGTCGCTGTGTTACGTAGTGCCAGGGATGGCAAAGTGGCGATGCCGTTGGAAACAGCCGATATAACTCTT
TTGGAGGCCGAAGGCTGGAAAGCTCCGGAGGTGTTTGTTGCCAAAGGGCGGGACGGCAAGACGGATATGTGGGGATTGAT
TGCCCGCCCCACCAACTTTGACCCGAACAAGAAATATCCGGTTATCGAATACATTTATCAGGGTCCCGGAGACCAGTATG
TTCCGAAGACTTTCCGTCCTTATGACTGGAATATGACTTCCTTGGCCGAACTTGGTTTTATCGTCGTAATGGTCGATGGA
ATGGGAACTTCTTTCCGTTCGCGTGCTTTTGAGAATGTATGTTATAAGAATTTGAAAGATGCCGGTCTGCCGGACCATAT
TGCCTGGATTAAGGCGGCTGCACGGAAATATCCTTATATGGATGTGGACAGGGTAGGTATTTACGGTTGTTCTGCCGGTG
GTCAGGAATCTACAAATGCAGTTTTGCTTTATCCTGATTTCTATAAAGCGGCTTATTCGGCTTGTGGTTGTCATGATAAC
CGTATGGATAAGATTTGGTGGAATGAACTTTGGTTGGGCTATCCGGTAGGAGATCAATATAAGGAAGGGTCTAATGTGGA
AAATGCACATCTGTTGAGTCGTCCTTTGATGTTAGTGGTGGGAGAACTGGATGATAATGTAGATCCTGCCTCTACCATGC
AGGTGGTCAATGCATTGATAAAGGCGAATAAAGATTTTGAATTGGTCGTGATTCCCGGAGCGCATCATACAATGGGGGAA
GATTTTGGCGAACATAAGCGGTATGATTTCTTTGTCCGTCATTTGATGCAGGTGAATCCACCGAAGTGGGATGAGATAAA
ATAG

Upstream 100 bases:

>100_bases
TTGACCCGGTAAAGACAAAAGCGGTAAAACTGGAGATTGTTCAGCCGGCCGATAATTCATCGGGTTTGTTTGAATGGGAA
GTAAAATAGAATAATTCAAA

Downstream 100 bases:

>100_bases
GAGGAGTGAGGTTTGTAGCTGTAGGAGTTTGTCAGTTATGATAAATAGAGGTGGCAGTGTTATGGAGGACAAGTCCATAG
CACTGCTTTTTTATGTAATT

Product: peptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MKVGKLGWLVAMFLSGGMAVAQGTVDDYRRAYALKEKFSADKVFYSNVNPQWIEGTHQFWYVRNTPDGCLYVSVDADKKA
RKELFDSHRLAKALGAASGKEVKPEALALGRLSVSKGLDTLRFVFNNQRWMYASRKNQLVNEGAVPLPPKQKHWMEVDDE
KTASPVPSPDGKWIAFIKNQNIYVKEVATGKEKQLSLDGTLGNYYSAYIRWSPDSKKVASCKIRPVEKRYVYYVESSPAD
QLQPKLHKQEYAKPGDELPFKVPCIYEVESGRSIIPSTELFDRQYEVYGPEWNPDSRAVTFEYNQRGHQVYRVLEFSAET
GKVRPLVEETSDTYVNYTRHFRHDLKDGKQMIWMSERDNWNHLYMYNRITAQPDYQITKGEWYVREVLRVDEDNRQIYFS
ANGMEAGEDPYLIRYYRIGFDGKGLTCLTPEEGMHRAWFSGDMKYLVDVYSMVDKVPVAVLRSARDGKVAMPLETADITL
LEAEGWKAPEVFVAKGRDGKTDMWGLIARPTNFDPNKKYPVIEYIYQGPGDQYVPKTFRPYDWNMTSLAELGFIVVMVDG
MGTSFRSRAFENVCYKNLKDAGLPDHIAWIKAAARKYPYMDVDRVGIYGCSAGGQESTNAVLLYPDFYKAAYSACGCHDN
RMDKIWWNELWLGYPVGDQYKEGSNVENAHLLSRPLMLVVGELDDNVDPASTMQVVNALIKANKDFELVVIPGAHHTMGE
DFGEHKRYDFFVRHLMQVNPPKWDEIK

Sequences:

>Translated_747_residues
MKVGKLGWLVAMFLSGGMAVAQGTVDDYRRAYALKEKFSADKVFYSNVNPQWIEGTHQFWYVRNTPDGCLYVSVDADKKA
RKELFDSHRLAKALGAASGKEVKPEALALGRLSVSKGLDTLRFVFNNQRWMYASRKNQLVNEGAVPLPPKQKHWMEVDDE
KTASPVPSPDGKWIAFIKNQNIYVKEVATGKEKQLSLDGTLGNYYSAYIRWSPDSKKVASCKIRPVEKRYVYYVESSPAD
QLQPKLHKQEYAKPGDELPFKVPCIYEVESGRSIIPSTELFDRQYEVYGPEWNPDSRAVTFEYNQRGHQVYRVLEFSAET
GKVRPLVEETSDTYVNYTRHFRHDLKDGKQMIWMSERDNWNHLYMYNRITAQPDYQITKGEWYVREVLRVDEDNRQIYFS
ANGMEAGEDPYLIRYYRIGFDGKGLTCLTPEEGMHRAWFSGDMKYLVDVYSMVDKVPVAVLRSARDGKVAMPLETADITL
LEAEGWKAPEVFVAKGRDGKTDMWGLIARPTNFDPNKKYPVIEYIYQGPGDQYVPKTFRPYDWNMTSLAELGFIVVMVDG
MGTSFRSRAFENVCYKNLKDAGLPDHIAWIKAAARKYPYMDVDRVGIYGCSAGGQESTNAVLLYPDFYKAAYSACGCHDN
RMDKIWWNELWLGYPVGDQYKEGSNVENAHLLSRPLMLVVGELDDNVDPASTMQVVNALIKANKDFELVVIPGAHHTMGE
DFGEHKRYDFFVRHLMQVNPPKWDEIK
>Mature_747_residues
MKVGKLGWLVAMFLSGGMAVAQGTVDDYRRAYALKEKFSADKVFYSNVNPQWIEGTHQFWYVRNTPDGCLYVSVDADKKA
RKELFDSHRLAKALGAASGKEVKPEALALGRLSVSKGLDTLRFVFNNQRWMYASRKNQLVNEGAVPLPPKQKHWMEVDDE
KTASPVPSPDGKWIAFIKNQNIYVKEVATGKEKQLSLDGTLGNYYSAYIRWSPDSKKVASCKIRPVEKRYVYYVESSPAD
QLQPKLHKQEYAKPGDELPFKVPCIYEVESGRSIIPSTELFDRQYEVYGPEWNPDSRAVTFEYNQRGHQVYRVLEFSAET
GKVRPLVEETSDTYVNYTRHFRHDLKDGKQMIWMSERDNWNHLYMYNRITAQPDYQITKGEWYVREVLRVDEDNRQIYFS
ANGMEAGEDPYLIRYYRIGFDGKGLTCLTPEEGMHRAWFSGDMKYLVDVYSMVDKVPVAVLRSARDGKVAMPLETADITL
LEAEGWKAPEVFVAKGRDGKTDMWGLIARPTNFDPNKKYPVIEYIYQGPGDQYVPKTFRPYDWNMTSLAELGFIVVMVDG
MGTSFRSRAFENVCYKNLKDAGLPDHIAWIKAAARKYPYMDVDRVGIYGCSAGGQESTNAVLLYPDFYKAAYSACGCHDN
RMDKIWWNELWLGYPVGDQYKEGSNVENAHLLSRPLMLVVGELDDNVDPASTMQVVNALIKANKDFELVVIPGAHHTMGE
DFGEHKRYDFFVRHLMQVNPPKWDEIK

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=466, Percent_Identity=27.0386266094421, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI37577089, Length=466, Percent_Identity=27.0386266094421, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI194394146, Length=380, Percent_Identity=25.7894736842105, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI16933540, Length=762, Percent_Identity=21.6535433070866, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI37577091, Length=467, Percent_Identity=25.4817987152034, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI295842359, Length=541, Percent_Identity=22.365988909427, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI85787627, Length=612, Percent_Identity=21.8954248366013, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI52426756, Length=612, Percent_Identity=21.8954248366013, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI295842403, Length=541, Percent_Identity=22.365988909427, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI295849272, Length=612, Percent_Identity=21.8954248366013, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI18765694, Length=675, Percent_Identity=22.5185185185185, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI86792774, Length=595, Percent_Identity=21.0084033613445, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI86792863, Length=595, Percent_Identity=21.0084033613445, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI86792778, Length=595, Percent_Identity=21.0084033613445, Blast_Score=88, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17508017, Length=344, Percent_Identity=27.906976744186, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17508019, Length=344, Percent_Identity=27.906976744186, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17564632, Length=210, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17564634, Length=210, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324793, Length=691, Percent_Identity=21.7076700434153, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321817, Length=721, Percent_Identity=22.1914008321775, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45551969, Length=499, Percent_Identity=23.4468937875752, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45550825, Length=499, Percent_Identity=23.2464929859719, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45553511, Length=499, Percent_Identity=23.2464929859719, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161083744, Length=626, Percent_Identity=22.2044728434505, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17933704, Length=626, Percent_Identity=22.2044728434505, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221331178, Length=626, Percent_Identity=22.2044728434505, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24582257, Length=211, Percent_Identity=25.5924170616114, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 85689; Mature: 85689

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGKLGWLVAMFLSGGMAVAQGTVDDYRRAYALKEKFSADKVFYSNVNPQWIEGTHQFW
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCEEEE
YVRNTPDGCLYVSVDADKKARKELFDSHRLAKALGAASGKEVKPEALALGRLSVSKGLDT
EEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEECHHHHHCCHH
LRFVFNNQRWMYASRKNQLVNEGAVPLPPKQKHWMEVDDEKTASPVPSPDGKWIAFIKNQ
EEHEECCCEEEEECHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEECC
NIYVKEVATGKEKQLSLDGTLGNYYSAYIRWSPDSKKVASCKIRPVEKRYVYYVESSPAD
CEEEEEECCCCCCEEEECCCCCCEEEEEEEECCCCCCEEEEEEEEECEEEEEEEECCCHH
QLQPKLHKQEYAKPGDELPFKVPCIYEVESGRSIIPSTELFDRQYEVYGPEWNPDSRAVT
HHHHHHHHHHHCCCCCCCCEECCEEEEECCCCEECCCHHHHCCEEEEECCCCCCCCCEEE
FEYNQRGHQVYRVLEFSAETGKVRPLVEETSDTYVNYTRHFRHDLKDGKQMIWMSERDNW
EEECCCCCEEEEEEEECCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCC
NHLYMYNRITAQPDYQITKGEWYVREVLRVDEDNRQIYFSANGMEAGEDPYLIRYYRIGF
CEEEEEEEEECCCCCEEECCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEEE
DGKGLTCLTPEEGMHRAWFSGDMKYLVDVYSMVDKVPVAVLRSARDGKVAMPLETADITL
CCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEE
LEAEGWKAPEVFVAKGRDGKTDMWGLIARPTNFDPNKKYPVIEYIYQGPGDQYVPKTFRP
EECCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
YDWNMTSLAELGFIVVMVDGMGTSFRSRAFENVCYKNLKDAGLPDHIAWIKAAARKYPYM
CCCCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
DVDRVGIYGCSAGGQESTNAVLLYPDFYKAAYSACGCHDNRMDKIWWNELWLGYPVGDQY
CCCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCEEHHHEEEECCCCCCC
KEGSNVENAHLLSRPLMLVVGELDDNVDPASTMQVVNALIKANKDFELVVIPGAHHTMGE
CCCCCCCHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
DFGEHKRYDFFVRHLMQVNPPKWDEIK
CHHHCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKVGKLGWLVAMFLSGGMAVAQGTVDDYRRAYALKEKFSADKVFYSNVNPQWIEGTHQFW
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCEEEE
YVRNTPDGCLYVSVDADKKARKELFDSHRLAKALGAASGKEVKPEALALGRLSVSKGLDT
EEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEECHHHHHCCHH
LRFVFNNQRWMYASRKNQLVNEGAVPLPPKQKHWMEVDDEKTASPVPSPDGKWIAFIKNQ
EEHEECCCEEEEECHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEECC
NIYVKEVATGKEKQLSLDGTLGNYYSAYIRWSPDSKKVASCKIRPVEKRYVYYVESSPAD
CEEEEEECCCCCCEEEECCCCCCEEEEEEEECCCCCCEEEEEEEEECEEEEEEEECCCHH
QLQPKLHKQEYAKPGDELPFKVPCIYEVESGRSIIPSTELFDRQYEVYGPEWNPDSRAVT
HHHHHHHHHHHCCCCCCCCEECCEEEEECCCCEECCCHHHHCCEEEEECCCCCCCCCEEE
FEYNQRGHQVYRVLEFSAETGKVRPLVEETSDTYVNYTRHFRHDLKDGKQMIWMSERDNW
EEECCCCCEEEEEEEECCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCC
NHLYMYNRITAQPDYQITKGEWYVREVLRVDEDNRQIYFSANGMEAGEDPYLIRYYRIGF
CEEEEEEEEECCCCCEEECCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEEE
DGKGLTCLTPEEGMHRAWFSGDMKYLVDVYSMVDKVPVAVLRSARDGKVAMPLETADITL
CCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEE
LEAEGWKAPEVFVAKGRDGKTDMWGLIARPTNFDPNKKYPVIEYIYQGPGDQYVPKTFRP
EECCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
YDWNMTSLAELGFIVVMVDGMGTSFRSRAFENVCYKNLKDAGLPDHIAWIKAAARKYPYM
CCCCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
DVDRVGIYGCSAGGQESTNAVLLYPDFYKAAYSACGCHDNRMDKIWWNELWLGYPVGDQY
CCCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCEEHHHEEEECCCCCCC
KEGSNVENAHLLSRPLMLVVGELDDNVDPASTMQVVNALIKANKDFELVVIPGAHHTMGE
CCCCCCCHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
DFGEHKRYDFFVRHLMQVNPPKWDEIK
CHHHCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA