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The map label for this gene is fabF [H]

Identifier: 150003589

GI number: 150003589

Start: 1352193

End: 1353923

Strand: Direct

Name: fabF [H]

Synonym: BVU_1018

Alternate gene names: 150003589

Gene position: 1352193-1353923 (Clockwise)

Preceding gene: 150003588

Following gene: 150003590

Centisome position: 26.19

GC content: 49.57

Gene sequence:

>1731_bases
ATGGAACATCATCTGACTACCTATATCACCCATGATACCCTGATCAGCGCGCTGGGTTTCGGCACACAGGAAAATCTGGA
AGCCATCCGGAGCTATCACAGCGGTATCACCCTGCAGACGGACAAACGGATTGCGGACACTCCCCTATTGGCAGCCACTC
TCTCGCAAGAGAGATTGCAACAACAGGCGGAAGCCATAGGAGTAAGTGGCTATCCCCGGATGGAACAACTGTTCATACTG
ACTATCAACGAACTCATCCGTCAGTCCGGACAAACTTTGGAAGACAAAACCTGCGGACTCATCCTCTCCACCACCAAAGG
GAACATCGATTTACTGGCCCGTCATACGGAACATCCCGATGAAGCGGTCTTTCTTTGGAAAATGGCAGAAAACATTGCCG
GTTATTTCCATGCCGAGGAACGGGTGCATGTCATTTCCAATGCCTGCATTTCAGGAGTGTCAGCCCTCATAGCAGGAAAA
CGCATGATAGAGAACGGTATCTACCGCCGGGTAATCGTAGCGGGAGGTGACCTTCTCTCTCATTTCATCACCAGCGGTTT
CGGGTCTTTCCGGTCTCTCAGCTCCCGCCCATGCCGTCCGTATGACAGCAGCCGTGACGGATTGAACTTGGGAGAGGCCT
GCGGAGCCGTATTGCTCAGTTCAGAAGGAACAGAAGAACATGTTATCCTTTCGGGAGGAGCCGTCAGTAACGATGCCAAC
CACATCTCCGGTCCTTCCCGCACGGGAGACGGACTCTATTTCGCCATCCGCCAAGCCATGCAGGAAGCAGGGACAGCCCC
TCAGGATATCAGCTTTGTCAATGCACACGGCACAGCTACCGTATACAATGACGAAATGGAATCCAAAGCCCTCACACTGG
CTCATCTGGAACAAGTGCCCGTCCATAGTTTGAAGCCCTATTTCGGCCATACCTTGGGAGCATCGGGAATCATTGAAAGC
ATTGTCTGTATGCACGAACTGAAACAAGGCATCCTGTTCGGCACTCCGGGTTACGAAACACCGGGAGTTCCTATGCCGAT
ACCGGTCTATGCCACCCACCGGAGCATCCCGATGAAACATTGCGTAAAAACCGCTTCGGGATTCGGCGGATGCAACGCAG
CCATTGTCTTATCTTTACCGGAATATACTCCGTTCAAGGATGAGGACAACACCTTGCCCGAAATCCGATGTACACGGGAG
GTTCGTATTGAAAACAGTTCTGTCTTCATAAACAACGAACTTATTTTTCATTCCGAAGAACCGGATTTCGGCACATTTAT
ACGTGATACCTATAAAAAAACAGGCGGAAACAACCTGAAATTCTATAAAATGGATGACCTTTGCAAATTGGGATATGTGG
CCGCCGAATACTTGCTGGAAGGTAAGACATTCGCTCCACTGGAAATGGGGATGTTACTTGCCAATGCCGCTTCCTCTCTG
CATACGGACATCAGACACCAGCAACTGATAGACCGGGAAGGAGACCAGGCAGCCAGTCCGGCTGTATTTGTTTACACACT
ACCCAATGTAGTGTCCGGCGAGATTTGCATCCGCCACAAGATACAAGGGGAAAACACCTTTTTCATCACTGAAGCCTATC
AGCCGGAAAAACTGGAAAGATACGCACGTATAGTCATGCAAAAAGGGAAACTGAACTATTGCATCATCGGGTGGTGTGAA
TTATGGAAGAACACCTATAAAGCAGTATTTAAACTGATCGAAAAACAATAA

Upstream 100 bases:

>100_bases
AAAACATTGTGGCAACAGGAACCACTACACAGGTATTTCTGAATACAAATAGAGAACTGGAACTGGTTAATCCTGCCTTT
TACATAGAGTGGAAAAAGAA

Downstream 100 bases:

>100_bases
AGAATATGGAAGAATTGATTGATAAACTGAAAGTTGAATTAATAGAAGCATTGAACCTGGAAGAAATCACTCCGGAGGAC
ATTGACAGTGAAGCACCTTT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MEHHLTTYITHDTLISALGFGTQENLEAIRSYHSGITLQTDKRIADTPLLAATLSQERLQQQAEAIGVSGYPRMEQLFIL
TINELIRQSGQTLEDKTCGLILSTTKGNIDLLARHTEHPDEAVFLWKMAENIAGYFHAEERVHVISNACISGVSALIAGK
RMIENGIYRRVIVAGGDLLSHFITSGFGSFRSLSSRPCRPYDSSRDGLNLGEACGAVLLSSEGTEEHVILSGGAVSNDAN
HISGPSRTGDGLYFAIRQAMQEAGTAPQDISFVNAHGTATVYNDEMESKALTLAHLEQVPVHSLKPYFGHTLGASGIIES
IVCMHELKQGILFGTPGYETPGVPMPIPVYATHRSIPMKHCVKTASGFGGCNAAIVLSLPEYTPFKDEDNTLPEIRCTRE
VRIENSSVFINNELIFHSEEPDFGTFIRDTYKKTGGNNLKFYKMDDLCKLGYVAAEYLLEGKTFAPLEMGMLLANAASSL
HTDIRHQQLIDREGDQAASPAVFVYTLPNVVSGEICIRHKIQGENTFFITEAYQPEKLERYARIVMQKGKLNYCIIGWCE
LWKNTYKAVFKLIEKQ

Sequences:

>Translated_576_residues
MEHHLTTYITHDTLISALGFGTQENLEAIRSYHSGITLQTDKRIADTPLLAATLSQERLQQQAEAIGVSGYPRMEQLFIL
TINELIRQSGQTLEDKTCGLILSTTKGNIDLLARHTEHPDEAVFLWKMAENIAGYFHAEERVHVISNACISGVSALIAGK
RMIENGIYRRVIVAGGDLLSHFITSGFGSFRSLSSRPCRPYDSSRDGLNLGEACGAVLLSSEGTEEHVILSGGAVSNDAN
HISGPSRTGDGLYFAIRQAMQEAGTAPQDISFVNAHGTATVYNDEMESKALTLAHLEQVPVHSLKPYFGHTLGASGIIES
IVCMHELKQGILFGTPGYETPGVPMPIPVYATHRSIPMKHCVKTASGFGGCNAAIVLSLPEYTPFKDEDNTLPEIRCTRE
VRIENSSVFINNELIFHSEEPDFGTFIRDTYKKTGGNNLKFYKMDDLCKLGYVAAEYLLEGKTFAPLEMGMLLANAASSL
HTDIRHQQLIDREGDQAASPAVFVYTLPNVVSGEICIRHKIQGENTFFITEAYQPEKLERYARIVMQKGKLNYCIIGWCE
LWKNTYKAVFKLIEKQ
>Mature_576_residues
MEHHLTTYITHDTLISALGFGTQENLEAIRSYHSGITLQTDKRIADTPLLAATLSQERLQQQAEAIGVSGYPRMEQLFIL
TINELIRQSGQTLEDKTCGLILSTTKGNIDLLARHTEHPDEAVFLWKMAENIAGYFHAEERVHVISNACISGVSALIAGK
RMIENGIYRRVIVAGGDLLSHFITSGFGSFRSLSSRPCRPYDSSRDGLNLGEACGAVLLSSEGTEEHVILSGGAVSNDAN
HISGPSRTGDGLYFAIRQAMQEAGTAPQDISFVNAHGTATVYNDEMESKALTLAHLEQVPVHSLKPYFGHTLGASGIIES
IVCMHELKQGILFGTPGYETPGVPMPIPVYATHRSIPMKHCVKTASGFGGCNAAIVLSLPEYTPFKDEDNTLPEIRCTRE
VRIENSSVFINNELIFHSEEPDFGTFIRDTYKKTGGNNLKFYKMDDLCKLGYVAAEYLLEGKTFAPLEMGMLLANAASSL
HTDIRHQQLIDREGDQAASPAVFVYTLPNVVSGEICIRHKIQGENTFFITEAYQPEKLERYARIVMQKGKLNYCIIGWCE
LWKNTYKAVFKLIEKQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=262, Percent_Identity=31.2977099236641, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI41872631, Length=272, Percent_Identity=27.5735294117647, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI223972627, Length=151, Percent_Identity=30.4635761589404, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1787337, Length=251, Percent_Identity=30.6772908366534, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788663, Length=409, Percent_Identity=23.4718826405868, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983541, Length=226, Percent_Identity=29.2035398230088, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983535, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=215, Percent_Identity=30.6976744186047, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644341, Length=255, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 63631; Mature: 63631

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00098 THIOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHHLTTYITHDTLISALGFGTQENLEAIRSYHSGITLQTDKRIADTPLLAATLSQERLQ
CCCCEEEEEEHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHH
QQAEAIGVSGYPRMEQLFILTINELIRQSGQTLEDKTCGLILSTTKGNIDLLARHTEHPD
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCC
EAVFLWKMAENIAGYFHAEERVHVISNACISGVSALIAGKRMIENGIYRRVIVAGGDLLS
HHEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHH
HFITSGFGSFRSLSSRPCRPYDSSRDGLNLGEACGAVLLSSEGTEEHVILSGGAVSNDAN
HHHHHCCHHHHHCCCCCCCCCCCCCCCCCHHHHHCEEEECCCCCCCEEEEECCCCCCCCC
HISGPSRTGDGLYFAIRQAMQEAGTAPQDISFVNAHGTATVYNDEMESKALTLAHLEQVP
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHCC
VHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYETPGVPMPIPVYATHRSIPMKH
HHHCCHHHCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCEEEECCCCCCHHH
CVKTASGFGGCNAAIVLSLPEYTPFKDEDNTLPEIRCTREVRIENSSVFINNELIFHSEE
HHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECEEEEEECCEEEEECEEEEECCC
PDFGTFIRDTYKKTGGNNLKFYKMDDLCKLGYVAAEYLLEGKTFAPLEMGMLLANAASSL
CCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
HTDIRHQQLIDREGDQAASPAVFVYTLPNVVSGEICIRHKIQGENTFFITEAYQPEKLER
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHH
YARIVMQKGKLNYCIIGWCELWKNTYKAVFKLIEKQ
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHHLTTYITHDTLISALGFGTQENLEAIRSYHSGITLQTDKRIADTPLLAATLSQERLQ
CCCCEEEEEEHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHH
QQAEAIGVSGYPRMEQLFILTINELIRQSGQTLEDKTCGLILSTTKGNIDLLARHTEHPD
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCC
EAVFLWKMAENIAGYFHAEERVHVISNACISGVSALIAGKRMIENGIYRRVIVAGGDLLS
HHEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHH
HFITSGFGSFRSLSSRPCRPYDSSRDGLNLGEACGAVLLSSEGTEEHVILSGGAVSNDAN
HHHHHCCHHHHHCCCCCCCCCCCCCCCCCHHHHHCEEEECCCCCCCEEEEECCCCCCCCC
HISGPSRTGDGLYFAIRQAMQEAGTAPQDISFVNAHGTATVYNDEMESKALTLAHLEQVP
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHCC
VHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYETPGVPMPIPVYATHRSIPMKH
HHHCCHHHCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCEEEECCCCCCHHH
CVKTASGFGGCNAAIVLSLPEYTPFKDEDNTLPEIRCTREVRIENSSVFINNELIFHSEE
HHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECEEEEEECCEEEEECEEEEECCC
PDFGTFIRDTYKKTGGNNLKFYKMDDLCKLGYVAAEYLLEGKTFAPLEMGMLLANAASSL
CCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
HTDIRHQQLIDREGDQAASPAVFVYTLPNVVSGEICIRHKIQGENTFFITEAYQPEKLER
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHH
YARIVMQKGKLNYCIIGWCELWKNTYKAVFKLIEKQ
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]