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The map label for this gene is fabB [H]

Identifier: 150003583

GI number: 150003583

Start: 1347864

End: 1349093

Strand: Direct

Name: fabB [H]

Synonym: BVU_1012

Alternate gene names: 150003583

Gene position: 1347864-1349093 (Clockwise)

Preceding gene: 150003582

Following gene: 150003584

Centisome position: 26.11

GC content: 48.05

Gene sequence:

>1230_bases
ATGAGAAGAGTAGTGATTACAGGCATGGGTATTTATTCGTGCATAGGCAAGAACCAAGATGAGGTGAAAGACTCTTTGTT
CCAAGGGCGTTCAGGCATCGGCATCGATCCGGCACGTAAAGAGATGGGGTATTTTTCCGCATTGACAGGACTTGTCGAAC
GTCCTGATTTAAAGAAGTTATTGGACCGCAAAAAGAGGCATAGCCTCGCCGAACAGGGAGAATATGCCTATATGGCTACC
TTGGAGGCATTCCGTCAGGCACAAATAGACGAGGAGTTTTTATTAAATCATGAAGTAGGCATATTGTATGGAAATGACAG
TAGCGCCGCTCCGGTAATCGAGGCCATTGATGTCATTCGTGCCAAGAAGAATACGGCTATGGTGGGCTCCGGTTCTATCT
TCCAGTCCATGAACTCTACGATTACCATGAACCTTTCGGTTATTTTCCATTTGAAGGGAATTAATTTTACCATATCGGGA
GCTTGTGCCAGCGGTTCACACGCCATCGGCATGGCGTATATGCTTATCAAATCGGGACTTCAGGACTGCATTCTGTGCGG
AGGAGCACAAGAGGTAAATCCTTACTCCGTGGGTAGTTTCGACGGATTGGGCGCGTTCTCCACCCGTGAGGACGAACCGG
AAAAGGCATCGCGCCCCTTTGACAAGGGACGGGACGGTTTGGTACCCAGCGGAGGAGGCGCCAGCCTGGTACTCGAAAGT
TATGAATCAGCCGTAAGGCGCGGAGCTACTATTCTGGCAGAAGTCATAGGATACGGTTTTTCATCCAACGGAGATCATAT
TTCCGTACCGAATGTGGACGGTCCCAGACGCTCTTTACAGATGGCAATCAACGATGCGGGCATTCCCTTGGAAGAAATCC
AATATATCAATGCACACGCCACTTCCACCCCCGTGGGAGATTTGAATGAGGCAAAAGCCATAGCGGAAGTGTTCGGAAAC
CATCGGCCCTATGTCACATCCACCAAGTCACAAACCGGACATGAGATGTGGATGGCAGGCGCCAGTGAAGTCATTTATTC
CATCTTGATGATGAATAACGGATTTATCGCTCCTAATCTCAATTTTGAAGAACCCGATGAAGCCTCTGCTCTGCTGAACA
TCCCCTCCCGGAGGATAGAAACGGAATTTGACACCTTCTTGTCCAACTCATTCGGATTCGGAGGAACCAATTCCTCACTG
ATTATCCGTAAATTTAAAGAAAACAATTAA

Upstream 100 bases:

>100_bases
GAAGTAGCCGCACTGGTAGGCTTCCTGGCATCGGAACAAGCCTCCTATATCACCGGAGAAGTAATTTCCATCAATGGAGG
AATCTATACATAAGCAGAAG

Downstream 100 bases:

>100_bases
TTCAAACCAATATATAAATTTATGACCAACGAAGAAATCATCGAAAAGATCAGAACCACCCTGGCCGAAGAATTTGAGAT
TGATGTAGAACAGATCCAAC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRRVVITGMGIYSCIGKNQDEVKDSLFQGRSGIGIDPARKEMGYFSALTGLVERPDLKKLLDRKKRHSLAEQGEYAYMAT
LEAFRQAQIDEEFLLNHEVGILYGNDSSAAPVIEAIDVIRAKKNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISG
ACASGSHAIGMAYMLIKSGLQDCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDKGRDGLVPSGGGASLVLES
YESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAINDAGIPLEEIQYINAHATSTPVGDLNEAKAIAEVFGN
HRPYVTSTKSQTGHEMWMAGASEVIYSILMMNNGFIAPNLNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSL
IIRKFKENN

Sequences:

>Translated_409_residues
MRRVVITGMGIYSCIGKNQDEVKDSLFQGRSGIGIDPARKEMGYFSALTGLVERPDLKKLLDRKKRHSLAEQGEYAYMAT
LEAFRQAQIDEEFLLNHEVGILYGNDSSAAPVIEAIDVIRAKKNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISG
ACASGSHAIGMAYMLIKSGLQDCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDKGRDGLVPSGGGASLVLES
YESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAINDAGIPLEEIQYINAHATSTPVGDLNEAKAIAEVFGN
HRPYVTSTKSQTGHEMWMAGASEVIYSILMMNNGFIAPNLNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSL
IIRKFKENN
>Mature_409_residues
MRRVVITGMGIYSCIGKNQDEVKDSLFQGRSGIGIDPARKEMGYFSALTGLVERPDLKKLLDRKKRHSLAEQGEYAYMAT
LEAFRQAQIDEEFLLNHEVGILYGNDSSAAPVIEAIDVIRAKKNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISG
ACASGSHAIGMAYMLIKSGLQDCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDKGRDGLVPSGGGASLVLES
YESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAINDAGIPLEEIQYINAHATSTPVGDLNEAKAIAEVFGN
HRPYVTSTKSQTGHEMWMAGASEVIYSILMMNNGFIAPNLNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSL
IIRKFKENN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=267, Percent_Identity=42.6966292134831, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=28.3687943262411, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI223972627, Length=176, Percent_Identity=39.7727272727273, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1788663, Length=411, Percent_Identity=41.8491484184915, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=36.5155131264916, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=32.8537170263789, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=40.4669260700389, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI212642053, Length=335, Percent_Identity=27.7611940298507, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=280, Percent_Identity=25, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=463, Percent_Identity=29.3736501079914, Blast_Score=162, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=35.9523809523809, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI221330659, Length=402, Percent_Identity=25.1243781094527, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19920632, Length=402, Percent_Identity=25.1243781094527, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24581345, Length=425, Percent_Identity=25.4117647058824, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 44240; Mature: 44240

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00098 THIOLASE_1 ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGMGIYSCIGKNQDEVKDSLFQGRSGIGIDPARKEMGYFSALTGLVERPDLKKL
CCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
LDRKKRHSLAEQGEYAYMATLEAFRQAQIDEEFLLNHEVGILYGNDSSAAPVIEAIDVIR
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
AKKNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACASGSHAIGMAYMLIKSGL
HCCCEEEEECCHHHHHCCCEEEEEEEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCH
QDCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDKGRDGLVPSGGGASLVLES
HHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHH
YESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAINDAGIPLEEIQYINAHA
HHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCHHHHHEECCCC
TSTPVGDLNEAKAIAEVFGNHRPYVTSTKSQTGHEMWMAGASEVIYSILMMNNGFIAPNL
CCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCC
NFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSLIIRKFKENN
CCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MRRVVITGMGIYSCIGKNQDEVKDSLFQGRSGIGIDPARKEMGYFSALTGLVERPDLKKL
CCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
LDRKKRHSLAEQGEYAYMATLEAFRQAQIDEEFLLNHEVGILYGNDSSAAPVIEAIDVIR
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
AKKNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACASGSHAIGMAYMLIKSGL
HCCCEEEEECCHHHHHCCCEEEEEEEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCH
QDCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDKGRDGLVPSGGGASLVLES
HHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHH
YESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAINDAGIPLEEIQYINAHA
HHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCHHHHHEECCCC
TSTPVGDLNEAKAIAEVFGNHRPYVTSTKSQTGHEMWMAGASEVIYSILMMNNGFIAPNL
CCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCC
NFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSLIIRKFKENN
CCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]