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The map label for this gene is hup [H]

Identifier: 150003567

GI number: 150003567

Start: 1316326

End: 1316598

Strand: Direct

Name: hup [H]

Synonym: BVU_0996

Alternate gene names: 150003567

Gene position: 1316326-1316598 (Clockwise)

Preceding gene: 150003561

Following gene: 150003568

Centisome position: 25.49

GC content: 42.86

Gene sequence:

>273_bases
ATGAATAAGGCAGATCTTATCAGCGCAGTCGCCGCTGAAGCCGGCTTGAGCAAAGTCGACGCAAAAAAAGCAGTTGAAGC
TTTCGTTTCAACTGTAACAAAAGCCCTCCAAGAAGGGGACAAAGTATCATTAATCGGATTCGGAACATTCTCTGTTGCTG
AAAGAAGTGCAAGAACAGGTATCAACCCATCCACAAAAGCAACGATTACTATTCCTGCTAAAAAAGTAACCAAGTTCAAA
CCAGGTGCTGAACTGGCAGACGCAATTAAATAA

Upstream 100 bases:

>100_bases
TTTTTAGGCTATCTGTTTGATTTCTAATTTTGAAAGCATATATTTGTCACTGATTTCGGTAAAATTTTTGTGTTACATTT
AATAATTAATCATTTTCGTT

Downstream 100 bases:

>100_bases
TTGCTATTTTACATAAAAGGACTTAAGGAAAGGGGCGCCGGTACTAGCGCCCTTTCTTCTTCATTTTTCTATTTGAACCT
ATGAAACCTAAAATGACAAC

Product: DNA-binding protein HU-beta

Products: NA

Alternate protein names: DNA-binding protein II; HB [H]

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MNKADLISAVAAEAGLSKVDAKKAVEAFVSTVTKALQEGDKVSLIGFGTFSVAERSARTGINPSTKATITIPAKKVTKFK
PGAELADAIK

Sequences:

>Translated_90_residues
MNKADLISAVAAEAGLSKVDAKKAVEAFVSTVTKALQEGDKVSLIGFGTFSVAERSARTGINPSTKATITIPAKKVTKFK
PGAELADAIK
>Mature_90_residues
MNKADLISAVAAEAGLSKVDAKKAVEAFVSTVTKALQEGDKVSLIGFGTFSVAERSARTGINPSTKATITIPAKKVTKFK
PGAELADAIK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1786644, Length=89, Percent_Identity=52.8089887640449, Blast_Score=93, Evalue=3e-21,
Organism=Escherichia coli, GI1790433, Length=90, Percent_Identity=48.8888888888889, Blast_Score=84, Evalue=3e-18,
Organism=Escherichia coli, GI1788005, Length=90, Percent_Identity=37.7777777777778, Blast_Score=74, Evalue=2e-15,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9278; Mature: 9278

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: PS00045 HISTONE_LIKE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKADLISAVAAEAGLSKVDAKKAVEAFVSTVTKALQEGDKVSLIGFGTFSVAERSARTG
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCC
INPSTKATITIPAKKVTKFKPGAELADAIK
CCCCCCEEEEECHHHHHCCCCCCHHHHHCC
>Mature Secondary Structure
MNKADLISAVAAEAGLSKVDAKKAVEAFVSTVTKALQEGDKVSLIGFGTFSVAERSARTG
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCC
INPSTKATITIPAKKVTKFKPGAELADAIK
CCCCCCEEEEECHHHHHCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1644313 [H]