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The map label for this gene is hisC [C]

Identifier: 150003459

GI number: 150003459

Start: 1191502

End: 1193307

Strand: Direct

Name: hisC [C]

Synonym: BVU_0886

Alternate gene names: 150003459

Gene position: 1191502-1193307 (Clockwise)

Preceding gene: 150003457

Following gene: 150003460

Centisome position: 23.08

GC content: 39.92

Gene sequence:

>1806_bases
ATGCAAGCAATCATTCTAGCCGCCGGCATGGGCAAGCGCTTGGGAGATCTTACCAAAGATAACACCAAGTGTATGATTAA
AGTAAACGGGACCTATCTGATAGACCGTCTGCTCTCACAGTTAGATTCATTAAATCTGGAACGCATTATTTTAGTCATAG
GCTACCAGGGAGAGAAATTACGTACCCACATAGAGAAACAAAGTAGAAATACTCCGATAGAATATATTTACAATCCTGTC
TACAATAAGACCAATAATATCTATTCTCTCTATCTTGCTAAAGAGGAATTGCAAAAGCAAGATACTTTATTAATTGAATC
CGATTTGATTTTTGAGGATACACTTTTCCACAAAATTTTAAATAACCCCTATCCCAATCTGGCACTTGTAGCTAAATATG
AGCCATGGATGGACGGCACGATGGTACGGCTCAATACTGAAAATGACATCATTGATTTTATCTCAAAAAAAACGTTCCGC
TACGCAGATATTGACGATTACTACAAAACCGTCAATATCTATAAATTCAGTAAGGAGTTTCTCCGCAACAGTTATGTGCC
ATTTCTTGAAGCCTACAGCAAAGCCCTGGGTAATAACGAATATTACGAACAGGTATTACGGGTAATCACCCTGCTGGAGA
GATGTGAACTGAAAGGACTCCCTTTGGAAGGAGAACGCTGGTATGAGATTGATGATATACAAGATCTTGACATCGCTGAA
ACCATTTTTGCCGAACAGGACCAGCTACAACGCTACCAAAAAAGATATGGCGGATACTGGCGTTTCCCAAAGCTGAAAGA
TTTCTGCTATTTAGTAAACCCCTATTTTCCACCACAAAAAATGTGTGAAGAACTACAGGCTAATTTTAATGTGCTTCTCC
GTGAATACCCTTCCGGCATGGGAGTGAACACACTTGTCATGGCAAAAAACTTCGGTATCCGGCAAGATTATGTGGTTGTT
GGCAACGGAGCCGCCGAAATCATCAAAGCGCTGATGGAACATTCAGATGGCAAAATGGGAGTAATTTATCCCACTTTTGA
AGAATATCCCAACCGGCAATCAGAAGAAATCATTGCATTCTATCCACAGAATGCCGATTTTCATTATACGGCAAAAGAAC
TGATGCTTTTTTATGCGGACAAAGATATCCGCCATTTACTCTTGATCAATCCGGATAACCCATCAGGTAACTTCATCCCC
CTTAACGAACTTATGGATTTGCTGGCATGGACGCAGCAGCGAAATATCCACTTAATACTGGATGAATCTTTTGTTGACTT
CAGCGAAAAAAGTATCGAAAATACGCTGCTTAAGAATGAAGTTCTGGAAACATACCCACACCTCACAGTCATTAAAAGTA
TTTCCAAATCTTATGGAGTTCCGGGATTACGCTTGGGGATAGCCGCATCTTCCGACAAAGAGATAATATCCTATTTACGA
AAAAACATGGCTATATGGAATATAAACTCCTTTGCCGAATTCTATTTACAGATATACAGCAAGTATAATAATGATTATCA
AAATGCCTGTAAAAAATTCATAGCCGAGCGCCAACGCTTTTTCGAGGTATTGCAACAGGTTGACTTCCTACGTGTCATAC
CTTCACAAGCCAATTATTTCCTGTGCGAAGTAACTTCCCGCTTCAGTTCCACCAAACTCGTTTCTTTATTGCTGGAGCAT
AATCTCTTGTTAAAAGATTGTAGTACCAAGACAGGATTCGATGGCAGGAATTACATCCGTATCGCCATACGCGACACTGA
AGACAACAATTATCTGGCTGAAAACTTAAAAAAACTGCAAGCATGA

Upstream 100 bases:

>100_bases
TTTTACCCATTCCTGTTTAAAATTTGAGGCAAATATAAATAACATCGCTTATAAATGCTAATTAATTACTACTTTTGCAA
TATATATACCTAAATTTATT

Downstream 100 bases:

>100_bases
GTATCAATATCTGTATTTGTGGCGGTGGCGGTCTGGGGCACGTCATTGCAGGAGTAGCTGCACATAAAGGCTTTAATGTT
TCCGTCCTCACCCGGCATCC

Product: hemolysin erythrocyte lysis protein 2

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MQAIILAAGMGKRLGDLTKDNTKCMIKVNGTYLIDRLLSQLDSLNLERIILVIGYQGEKLRTHIEKQSRNTPIEYIYNPV
YNKTNNIYSLYLAKEELQKQDTLLIESDLIFEDTLFHKILNNPYPNLALVAKYEPWMDGTMVRLNTENDIIDFISKKTFR
YADIDDYYKTVNIYKFSKEFLRNSYVPFLEAYSKALGNNEYYEQVLRVITLLERCELKGLPLEGERWYEIDDIQDLDIAE
TIFAEQDQLQRYQKRYGGYWRFPKLKDFCYLVNPYFPPQKMCEELQANFNVLLREYPSGMGVNTLVMAKNFGIRQDYVVV
GNGAAEIIKALMEHSDGKMGVIYPTFEEYPNRQSEEIIAFYPQNADFHYTAKELMLFYADKDIRHLLLINPDNPSGNFIP
LNELMDLLAWTQQRNIHLILDESFVDFSEKSIENTLLKNEVLETYPHLTVIKSISKSYGVPGLRLGIAASSDKEIISYLR
KNMAIWNINSFAEFYLQIYSKYNNDYQNACKKFIAERQRFFEVLQQVDFLRVIPSQANYFLCEVTSRFSSTKLVSLLLEH
NLLLKDCSTKTGFDGRNYIRIAIRDTEDNNYLAENLKKLQA

Sequences:

>Translated_601_residues
MQAIILAAGMGKRLGDLTKDNTKCMIKVNGTYLIDRLLSQLDSLNLERIILVIGYQGEKLRTHIEKQSRNTPIEYIYNPV
YNKTNNIYSLYLAKEELQKQDTLLIESDLIFEDTLFHKILNNPYPNLALVAKYEPWMDGTMVRLNTENDIIDFISKKTFR
YADIDDYYKTVNIYKFSKEFLRNSYVPFLEAYSKALGNNEYYEQVLRVITLLERCELKGLPLEGERWYEIDDIQDLDIAE
TIFAEQDQLQRYQKRYGGYWRFPKLKDFCYLVNPYFPPQKMCEELQANFNVLLREYPSGMGVNTLVMAKNFGIRQDYVVV
GNGAAEIIKALMEHSDGKMGVIYPTFEEYPNRQSEEIIAFYPQNADFHYTAKELMLFYADKDIRHLLLINPDNPSGNFIP
LNELMDLLAWTQQRNIHLILDESFVDFSEKSIENTLLKNEVLETYPHLTVIKSISKSYGVPGLRLGIAASSDKEIISYLR
KNMAIWNINSFAEFYLQIYSKYNNDYQNACKKFIAERQRFFEVLQQVDFLRVIPSQANYFLCEVTSRFSSTKLVSLLLEH
NLLLKDCSTKTGFDGRNYIRIAIRDTEDNNYLAENLKKLQA
>Mature_601_residues
MQAIILAAGMGKRLGDLTKDNTKCMIKVNGTYLIDRLLSQLDSLNLERIILVIGYQGEKLRTHIEKQSRNTPIEYIYNPV
YNKTNNIYSLYLAKEELQKQDTLLIESDLIFEDTLFHKILNNPYPNLALVAKYEPWMDGTMVRLNTENDIIDFISKKTFR
YADIDDYYKTVNIYKFSKEFLRNSYVPFLEAYSKALGNNEYYEQVLRVITLLERCELKGLPLEGERWYEIDDIQDLDIAE
TIFAEQDQLQRYQKRYGGYWRFPKLKDFCYLVNPYFPPQKMCEELQANFNVLLREYPSGMGVNTLVMAKNFGIRQDYVVV
GNGAAEIIKALMEHSDGKMGVIYPTFEEYPNRQSEEIIAFYPQNADFHYTAKELMLFYADKDIRHLLLINPDNPSGNFIP
LNELMDLLAWTQQRNIHLILDESFVDFSEKSIENTLLKNEVLETYPHLTVIKSISKSYGVPGLRLGIAASSDKEIISYLR
KNMAIWNINSFAEFYLQIYSKYNNDYQNACKKFIAERQRFFEVLQQVDFLRVIPSQANYFLCEVTSRFSSTKLVSLLLEH
NLLLKDCSTKTGFDGRNYIRIAIRDTEDNNYLAENLKKLQA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To Rhizobium NGR234A y4qD [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=303, Percent_Identity=24.0924092409241, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 70268; Mature: 70268

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIILAAGMGKRLGDLTKDNTKCMIKVNGTYLIDRLLSQLDSLNLERIILVIGYQGEKL
CCEEEEECCCCCHHCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEEECCCHHH
RTHIEKQSRNTPIEYIYNPVYNKTNNIYSLYLAKEELQKQDTLLIESDLIFEDTLFHKIL
HHHHHHHCCCCCHHEEECCCCCCCCCEEEEEEEHHHHCCCCCEEEECCCHHHHHHHHHHH
NNPYPNLALVAKYEPWMDGTMVRLNTENDIIDFISKKTFRYADIDDYYKTVNIYKFSKEF
CCCCCCEEEEEEECCCCCCEEEEEECCCHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHH
LRNSYVPFLEAYSKALGNNEYYEQVLRVITLLERCELKGLPLEGERWYEIDDIQDLDIAE
HHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHHH
TIFAEQDQLQRYQKRYGGYWRFPKLKDFCYLVNPYFPPQKMCEELQANFNVLLREYPSGM
HHHHCHHHHHHHHHHHCCEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
GVNTLVMAKNFGIRQDYVVVGNGAAEIIKALMEHSDGKMGVIYPTFEEYPNRQSEEIIAF
CCEEEEEEECCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCEEEE
YPQNADFHYTAKELMLFYADKDIRHLLLINPDNPSGNFIPLNELMDLLAWTQQRNIHLIL
CCCCCCCEEEHHHHEEEEECCCCCEEEEECCCCCCCCEEEHHHHHHHHHHHCCCCEEEEE
DESFVDFSEKSIENTLLKNEVLETYPHLTVIKSISKSYGVPGLRLGIAASSDKEIISYLR
ECCHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
KNMAIWNINSFAEFYLQIYSKYNNDYQNACKKFIAERQRFFEVLQQVDFLRVIPSQANYF
HCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LCEVTSRFSSTKLVSLLLEHNLLLKDCSTKTGFDGRNYIRIAIRDTEDNNYLAENLKKLQ
EEEEHHCCCHHHHHHHHHHCCHHEECCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHC
A
C
>Mature Secondary Structure
MQAIILAAGMGKRLGDLTKDNTKCMIKVNGTYLIDRLLSQLDSLNLERIILVIGYQGEKL
CCEEEEECCCCCHHCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEEECCCHHH
RTHIEKQSRNTPIEYIYNPVYNKTNNIYSLYLAKEELQKQDTLLIESDLIFEDTLFHKIL
HHHHHHHCCCCCHHEEECCCCCCCCCEEEEEEEHHHHCCCCCEEEECCCHHHHHHHHHHH
NNPYPNLALVAKYEPWMDGTMVRLNTENDIIDFISKKTFRYADIDDYYKTVNIYKFSKEF
CCCCCCEEEEEEECCCCCCEEEEEECCCHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHH
LRNSYVPFLEAYSKALGNNEYYEQVLRVITLLERCELKGLPLEGERWYEIDDIQDLDIAE
HHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHHH
TIFAEQDQLQRYQKRYGGYWRFPKLKDFCYLVNPYFPPQKMCEELQANFNVLLREYPSGM
HHHHCHHHHHHHHHHHCCEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
GVNTLVMAKNFGIRQDYVVVGNGAAEIIKALMEHSDGKMGVIYPTFEEYPNRQSEEIIAF
CCEEEEEEECCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCEEEE
YPQNADFHYTAKELMLFYADKDIRHLLLINPDNPSGNFIPLNELMDLLAWTQQRNIHLIL
CCCCCCCEEEHHHHEEEEECCCCCEEEEECCCCCCCCEEEHHHHHHHHHHHCCCCEEEEE
DESFVDFSEKSIENTLLKNEVLETYPHLTVIKSISKSYGVPGLRLGIAASSDKEIISYLR
ECCHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
KNMAIWNINSFAEFYLQIYSKYNNDYQNACKKFIAERQRFFEVLQQVDFLRVIPSQANYF
HCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LCEVTSRFSSTKLVSLLLEHNLLLKDCSTKTGFDGRNYIRIAIRDTEDNNYLAENLKKLQ
EEEEHHCCCHHHHHHHHHHCCHHEECCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]