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The map label for this gene is uppS [H]

Identifier: 150003439

GI number: 150003439

Start: 1168953

End: 1169684

Strand: Direct

Name: uppS [H]

Synonym: BVU_0866

Alternate gene names: 150003439

Gene position: 1168953-1169684 (Clockwise)

Preceding gene: 150003438

Following gene: 150003440

Centisome position: 22.64

GC content: 42.76

Gene sequence:

>732_bases
ATGCCATATAGAGAGCAAATAGACAAAAGCCGTATACCTGCCCATGTAGCCATTATAATGGATGGAAATGGAAGATGGGC
TAAACAACGTGGACAGGCGCGCAGCTTCGGACATCAAGCCGGTGCAGAAACTGTACACATCATAGCAGAAGAAGCGGCTA
GACTGGGAGTCAAATACTTGACACTATATACTTTCTCTACCGAAAACTGGAATCGTCCGGTAGATGAAGTCGCTGCTCTG
ATGAGTCTTCTGATGGACTCCATTGAAGAAGAAACTTTCATGAAAAACAACATCAGTTTTCGCATTATCGGTGATACGGC
AAAGTTACCGGTAGAAGTTCTGGAACGATTGAACCAATGCATTGAACGCACCTCAATCAATACCGGTATGTGTCTGACAC
TTGCTTTAAGCTACTCTTCCAAATGGGAAATAACAGAAGCGGTAAGACAAATAGCGGCCAAGATTCAAAACGACAAACTA
GCCATTGAGGACATCGATGACAATTTGATAAGTGCACATTTAAGTACAAACTATATGCCCGACCCGGATTTGCTTATACG
TACCGGAGGAGAAATCCGCCTTAGCAACTATCTGCTTTGGCAATGTGCTTATTCCGAACTATATTTTTGTGAAACGTTCT
GGCCGGACTTCCGCGAAGAAGAATTTTGCAAAGCCATTTATGATTATCAGAAAAGAGAACGCCGTTTCGGCAAAACCAGT
GAACAAATATAA

Upstream 100 bases:

>100_bases
ATGGAGCCGAAGCGGAGAAGTATGGAGAGGACGAATCAATAAGTTGGGATTCGATTCCAAGGAATAAAGTCAAAGAGAGT
CATATAAAATAGATTGCGAC

Downstream 100 bases:

>100_bases
AGTTAGATAAAATGCTATATCGTATTTCACTTATACTATTAACGCTTACATGCCTATTTTGCTTTTCAACAGGCAGTTAC
GCCCAAGAAGCAAACGTAGA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MPYREQIDKSRIPAHVAIIMDGNGRWAKQRGQARSFGHQAGAETVHIIAEEAARLGVKYLTLYTFSTENWNRPVDEVAAL
MSLLMDSIEEETFMKNNISFRIIGDTAKLPVEVLERLNQCIERTSINTGMCLTLALSYSSKWEITEAVRQIAAKIQNDKL
AIEDIDDNLISAHLSTNYMPDPDLLIRTGGEIRLSNYLLWQCAYSELYFCETFWPDFREEEFCKAIYDYQKRERRFGKTS
EQI

Sequences:

>Translated_243_residues
MPYREQIDKSRIPAHVAIIMDGNGRWAKQRGQARSFGHQAGAETVHIIAEEAARLGVKYLTLYTFSTENWNRPVDEVAAL
MSLLMDSIEEETFMKNNISFRIIGDTAKLPVEVLERLNQCIERTSINTGMCLTLALSYSSKWEITEAVRQIAAKIQNDKL
AIEDIDDNLISAHLSTNYMPDPDLLIRTGGEIRLSNYLLWQCAYSELYFCETFWPDFREEEFCKAIYDYQKRERRFGKTS
EQI
>Mature_242_residues
PYREQIDKSRIPAHVAIIMDGNGRWAKQRGQARSFGHQAGAETVHIIAEEAARLGVKYLTLYTFSTENWNRPVDEVAALM
SLLMDSIEEETFMKNNISFRIIGDTAKLPVEVLERLNQCIERTSINTGMCLTLALSYSSKWEITEAVRQIAAKIQNDKLA
IEDIDDNLISAHLSTNYMPDPDLLIRTGGEIRLSNYLLWQCAYSELYFCETFWPDFREEEFCKAIYDYQKRERRFGKTSE
QI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=229, Percent_Identity=35.3711790393013, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI45580738, Length=229, Percent_Identity=35.3711790393013, Blast_Score=148, Evalue=4e-36,
Organism=Escherichia coli, GI1786371, Length=235, Percent_Identity=46.8085106382979, Blast_Score=236, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71993029, Length=234, Percent_Identity=32.9059829059829, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=34.8837209302326, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=32.4200913242009, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=35.5555555555556, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28065; Mature: 27934

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYREQIDKSRIPAHVAIIMDGNGRWAKQRGQARSFGHQAGAETVHIIAEEAARLGVKYL
CCCHHHHHHHCCCEEEEEEECCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCEEEE
TLYTFSTENWNRPVDEVAALMSLLMDSIEEETFMKNNISFRIIGDTAKLPVEVLERLNQC
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
IERTSINTGMCLTLALSYSSKWEITEAVRQIAAKIQNDKLAIEDIDDNLISAHLSTNYMP
HHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCC
DPDLLIRTGGEIRLSNYLLWQCAYSELYFCETFWPDFREEEFCKAIYDYQKRERRFGKTS
CCCEEEECCCCEEECCEEEEEEHHHHHEEHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
EQI
CCC
>Mature Secondary Structure 
PYREQIDKSRIPAHVAIIMDGNGRWAKQRGQARSFGHQAGAETVHIIAEEAARLGVKYL
CCHHHHHHHCCCEEEEEEECCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCEEEE
TLYTFSTENWNRPVDEVAALMSLLMDSIEEETFMKNNISFRIIGDTAKLPVEVLERLNQC
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
IERTSINTGMCLTLALSYSSKWEITEAVRQIAAKIQNDKLAIEDIDDNLISAHLSTNYMP
HHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCC
DPDLLIRTGGEIRLSNYLLWQCAYSELYFCETFWPDFREEEFCKAIYDYQKRERRFGKTS
CCCEEEECCCCEEECCEEEEEEHHHHHEEHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
EQI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]