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The map label for this gene is pyrE

Identifier: 150003433

GI number: 150003433

Start: 1163560

End: 1164198

Strand: Reverse

Name: pyrE

Synonym: BVU_0860

Alternate gene names: 150003433

Gene position: 1164198-1163560 (Counterclockwise)

Preceding gene: 150003434

Following gene: 150003432

Centisome position: 22.55

GC content: 43.51

Gene sequence:

>639_bases
ATGAAGACTTTAGAAAAATTATTCGCAGAGAAATTACTGAAGATTAAGGCTATCAAGTTGCAGCCGGCTAATCCTTTTAC
TTGGGCGTCCGGTTGGAAGTCGCCTTTTTATTGTGATAACCGCAAAACTCTTTCGTATCCTTCTCTTCGTAATTTTGTGA
AACTTGAGATTAGCCGTATTGTCCTGGAGAAGTTCGGTCAGGTAGATGCTATTGCCGGTGTGGCGACAGGGGCTATCCCT
CAAGGAGCTTTGGTGGCTGAAGAGTTGAATCTGCCGTTTGTGTATGTTCGTTCTACTCCAAAAGACCATGGCTTGGAAAA
CCTGATTGAAGGTGAACTTCGTCCTGGTATGAAAGTCGTAGTTATTGAGGACTTGATTTCAACTGGCGGCAGCAGTTTGA
AAGCTGTTGAAGCTATCCGTCGTGACGGATGTGAAGTGATTGGTATGGTCGCTGCATTTACTTATGGTTTCCCAGTGGCA
ATTGAAGCGTTTAAGGAAGCAAAAGTGAACTTGGTTACTCTGACTAATTATGAAGCTGTATTGGATTCAGCCTTGAAGAC
CGGATATATTAATGAAGAGGATGTTCCGGTTTTGGATAATTGGAGAAAGGATCCGGCTCATTGGGAGGCAGGCAAATAA

Upstream 100 bases:

>100_bases
ATAACAACAACTATTTTTTAGAAAAATACCTTGTCCGATTTTTCATTATCTCGATGTATTTCTATATTTTTGCACAATAT
TTATCAGATATAGTTGAGTT

Downstream 100 bases:

>100_bases
GTTATAGTTTTAAAACAAATATAATATGAAGAGAACCGTTCGGGAATTTTTATGGATTTCCGGATTGTTCTTTTCGTGTT
TTTAGAGAGCAGGTATTATG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKTLEKLFAEKLLKIKAIKLQPANPFTWASGWKSPFYCDNRKTLSYPSLRNFVKLEISRIVLEKFGQVDAIAGVATGAIP
QGALVAEELNLPFVYVRSTPKDHGLENLIEGELRPGMKVVVIEDLISTGGSSLKAVEAIRRDGCEVIGMVAAFTYGFPVA
IEAFKEAKVNLVTLTNYEAVLDSALKTGYINEEDVPVLDNWRKDPAHWEAGK

Sequences:

>Translated_212_residues
MKTLEKLFAEKLLKIKAIKLQPANPFTWASGWKSPFYCDNRKTLSYPSLRNFVKLEISRIVLEKFGQVDAIAGVATGAIP
QGALVAEELNLPFVYVRSTPKDHGLENLIEGELRPGMKVVVIEDLISTGGSSLKAVEAIRRDGCEVIGMVAAFTYGFPVA
IEAFKEAKVNLVTLTNYEAVLDSALKTGYINEEDVPVLDNWRKDPAHWEAGK
>Mature_212_residues
MKTLEKLFAEKLLKIKAIKLQPANPFTWASGWKSPFYCDNRKTLSYPSLRNFVKLEISRIVLEKFGQVDAIAGVATGAIP
QGALVAEELNLPFVYVRSTPKDHGLENLIEGELRPGMKVVVIEDLISTGGSSLKAVEAIRRDGCEVIGMVAAFTYGFPVA
IEAFKEAKVNLVTLTNYEAVLDSALKTGYINEEDVPVLDNWRKDPAHWEAGK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

Organism=Homo sapiens, GI4507835, Length=121, Percent_Identity=30.5785123966942, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508631, Length=190, Percent_Identity=28.9473684210526, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554964, Length=195, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_BACV8 (A6KYP1)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001298177.1
- ProteinModelPortal:   A6KYP1
- SMR:   A6KYP1
- STRING:   A6KYP1
- GeneID:   5301827
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_0860
- NMPDR:   fig|435590.6.peg.817
- eggNOG:   COG0461
- HOGENOM:   HBG404341
- OMA:   LPMTYVR
- ProtClustDB:   PRK00455
- HAMAP:   MF_01208
- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836
- TIGRFAMs:   TIGR00336

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 23411; Mature: 23411

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 97-97 BINDING 101-101 BINDING 103-103 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLEKLFAEKLLKIKAIKLQPANPFTWASGWKSPFYCDNRKTLSYPSLRNFVKLEISRI
CCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHH
VLEKFGQVDAIAGVATGAIPQGALVAEELNLPFVYVRSTPKDHGLENLIEGELRPGMKVV
HHHHCCCHHHHHHHHHCCCCCCCEEHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEE
VIEDLISTGGSSLKAVEAIRRDGCEVIGMVAAFTYGFPVAIEAFKEAKVNLVTLTNYEAV
EEHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCHHHH
LDSALKTGYINEEDVPVLDNWRKDPAHWEAGK
HHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKTLEKLFAEKLLKIKAIKLQPANPFTWASGWKSPFYCDNRKTLSYPSLRNFVKLEISRI
CCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHH
VLEKFGQVDAIAGVATGAIPQGALVAEELNLPFVYVRSTPKDHGLENLIEGELRPGMKVV
HHHHCCCHHHHHHHHHCCCCCCCEEHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEE
VIEDLISTGGSSLKAVEAIRRDGCEVIGMVAAFTYGFPVAIEAFKEAKVNLVTLTNYEAV
EEHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCHHHH
LDSALKTGYINEEDVPVLDNWRKDPAHWEAGK
HHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA