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The map label for this gene is purE [H]

Identifier: 148828394

GI number: 148828394

Start: 1845393

End: 1845728

Strand: Reverse

Name: purE [H]

Synonym: CGSHiGG_10015

Alternate gene names: 148828394

Gene position: 1845728-1845393 (Counterclockwise)

Preceding gene: 148828396

Following gene: 148828393

Centisome position: 97.8

GC content: 47.92

Gene sequence:

>336_bases
ATGCACAAAAAAATAGGCTACAAAGTAATTATTGCTGGGGCTGGCGGTGCGGCACATTTACCCGGTATGATCGCAGCGAA
AACGCTTGTGCCAGTGCTGGGCGTGCCAGTAAAAAGTTCTATGTTAAGTGGCATAGATAGCCTTTATTCAATTGTGCAAA
TGCCAAAAGGGATTCCAGTCGGAACATTAGCGATTGGTCCTGCAGGCGCGGCAAATGCTGGGTTGTTAGCAGCCCAAATT
CTAGCAGGTTGGGATGCAGAATTGCTTTCACGCTTGCAATCTTTCCGTGAAAGCCAAACTCGTGCTGTACTGGACAATCC
CGATCCACGCACATAA

Upstream 100 bases:

>100_bases
CAAGAGGCAACTCAGATTTTAGATGAATTAAAAGTACCTTATCATGTGGAAGTCGTCTCTGCTCATCGTACGCCTGATAA
ACTTTTTGAATTTGCTGAAA

Downstream 100 bases:

>100_bases
AAAATATCTTCAGATCTGACCGCACTTTTAAAGTGCGGTTGTTTTTTTCGTAAATTTAACGAGAAATATTATGCAAAACT
CCACCTTATACCCAACGGTT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 111; Mature: 111

Protein sequence:

>111_residues
MHKKIGYKVIIAGAGGAAHLPGMIAAKTLVPVLGVPVKSSMLSGIDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQI
LAGWDAELLSRLQSFRESQTRAVLDNPDPRT

Sequences:

>Translated_111_residues
MHKKIGYKVIIAGAGGAAHLPGMIAAKTLVPVLGVPVKSSMLSGIDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQI
LAGWDAELLSRLQSFRESQTRAVLDNPDPRT
>Mature_111_residues
MHKKIGYKVIIAGAGGAAHLPGMIAAKTLVPVLGVPVKSSMLSGIDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQI
LAGWDAELLSRLQSFRESQTRAVLDNPDPRT

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=108, Percent_Identity=77.7777777777778, Blast_Score=132, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324702, Length=101, Percent_Identity=55.4455445544555, Blast_Score=112, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 11370; Mature: 11370

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKIGYKVIIAGAGGAAHLPGMIAAKTLVPVLGVPVKSSMLSGIDSLYSIVQMPKGIPV
CCCCCCEEEEEEECCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
GTLAIGPAGAANAGLLAAQILAGWDAELLSRLQSFRESQTRAVLDNPDPRT
CEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHKKIGYKVIIAGAGGAAHLPGMIAAKTLVPVLGVPVKSSMLSGIDSLYSIVQMPKGIPV
CCCCCCEEEEEEECCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
GTLAIGPAGAANAGLLAAQILAGWDAELLSRLQSFRESQTRAVLDNPDPRT
CEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 7997179 [H]