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The map label for this gene is ccmE

Identifier: 148828255

GI number: 148828255

Start: 1685352

End: 1685873

Strand: Direct

Name: ccmE

Synonym: CGSHiGG_09105

Alternate gene names: 148828255

Gene position: 1685352-1685873 (Clockwise)

Preceding gene: 148828254

Following gene: 148828256

Centisome position: 89.3

GC content: 41.0

Gene sequence:

>522_bases
ATGAATCCAAGACGTAAATCCAGATTTAAATTAGTCATTTTTGTTGTGCTCGGCATTGCTATTGCAAGTGGATTGATGCT
GTATGCATTACGTCAAAATATCGACTTGTTTTATACACCATCTGAAGTGATTCAAGGTAAGGATAATAATCCGAATCAAA
AACCTGAAGTGGGGCAGCGTATTCGTGTTGGCGGTATGGTGGTTGAAGGCACGGTAGTGCGTGATCCAAAAAGCTTAAAA
GTGCGGTTTGATTTAAATGATATTGGTCCTGCGATTACTGTTGAATATGAAGGCATTTTGCCAGATCTTTTCCGTGAAGG
GCAGGGGATTGTGGCTCAAGGCGTATTAACTCAGTCAGCGGTTTTAAGCGCGACAGAAGTATTGGCTAAACACGATGAAA
ATTATGTGCCGCCAGAATTAGGCGAAAAAATGCAAAAAGTACATAAACCAATGGGGATTAAGGCAGCAGATTTAAAAGGC
GAAAGTGAGCGTGATCGTCAAGAAAAAGAAGGCGCAAAATGA

Upstream 100 bases:

>100_bases
TTGTTCAAAGTGTAAAACAACGCAAGACAGTGTTACAAAATGTATTGCGTGAGCAACAACGCGAAGAACGTTTACAACAA
GCAAATAAGGGGAACACACT

Downstream 100 bases:

>100_bases
TTGCTGAATTAGGAAATTATGCGCTGGCTTTAAGTTTAGCTGTATCGCTTATGTTGGCGATTTTCCCTTTGTGGGGGGCG
GAAAAGGGCAATGTACAATT

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MNPRRKSRFKLVIFVVLGIAIASGLMLYALRQNIDLFYTPSEVIQGKDNNPNQKPEVGQRIRVGGMVVEGTVVRDPKSLK
VRFDLNDIGPAITVEYEGILPDLFREGQGIVAQGVLTQSAVLSATEVLAKHDENYVPPELGEKMQKVHKPMGIKAADLKG
ESERDRQEKEGAK

Sequences:

>Translated_173_residues
MNPRRKSRFKLVIFVVLGIAIASGLMLYALRQNIDLFYTPSEVIQGKDNNPNQKPEVGQRIRVGGMVVEGTVVRDPKSLK
VRFDLNDIGPAITVEYEGILPDLFREGQGIVAQGVLTQSAVLSATEVLAKHDENYVPPELGEKMQKVHKPMGIKAADLKG
ESERDRQEKEGAK
>Mature_173_residues
MNPRRKSRFKLVIFVVLGIAIASGLMLYALRQNIDLFYTPSEVIQGKDNNPNQKPEVGQRIRVGGMVVEGTVVRDPKSLK
VRFDLNDIGPAITVEYEGILPDLFREGQGIVAQGVLTQSAVLSATEVLAKHDENYVPPELGEKMQKVHKPMGIKAADLKG
ESERDRQEKEGAK

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=149, Percent_Identity=57.7181208053691, Blast_Score=173, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_HAEI8 (Q4QLJ5)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248762.1
- ProteinModelPortal:   Q4QLJ5
- SMR:   Q4QLJ5
- STRING:   Q4QLJ5
- GeneID:   3430528
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI1257
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   ICFCSAC
- PhylomeDB:   Q4QLJ5
- ProtClustDB:   PRK13165
- BioCyc:   HINF281310:NTHI1257-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 19152; Mature: 19152

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: BINDING 131-131

Signals:

None

Transmembrane regions:

HASH(0x10962d10)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRRKSRFKLVIFVVLGIAIASGLMLYALRQNIDLFYTPSEVIQGKDNNPNQKPEVGQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHCCCCCCCCCCCCCCCE
IRVGGMVVEGTVVRDPKSLKVRFDLNDIGPAITVEYEGILPDLFREGQGIVAQGVLTQSA
EEECCEEEECEEEECCCCEEEEEEHHHCCCEEEEEECCCCHHHHHCCCCEEEHHHHHHHH
VLSATEVLAKHDENYVPPELGEKMQKVHKPMGIKAADLKGESERDRQEKEGAK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHCCCH
>Mature Secondary Structure
MNPRRKSRFKLVIFVVLGIAIASGLMLYALRQNIDLFYTPSEVIQGKDNNPNQKPEVGQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHCCCCCCCCCCCCCCCE
IRVGGMVVEGTVVRDPKSLKVRFDLNDIGPAITVEYEGILPDLFREGQGIVAQGVLTQSA
EEECCEEEECEEEECCCCEEEEEEHHHCCCEEEEEECCCCHHHHHCCCCEEEHHHHHHHH
VLSATEVLAKHDENYVPPELGEKMQKVHKPMGIKAADLKGESERDRQEKEGAK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA