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The map label for this gene is glyA [H]

Identifier: 148828069

GI number: 148828069

Start: 1474146

End: 1475411

Strand: Direct

Name: glyA [H]

Synonym: CGSHiGG_07995

Alternate gene names: 148828069

Gene position: 1474146-1475411 (Clockwise)

Preceding gene: 148828068

Following gene: 148828070

Centisome position: 78.11

GC content: 39.89

Gene sequence:

>1266_bases
ATGTTTACAAGAAATATGACTATCGCTGATTACGATCCAGTATTGTGGCAAGCGATCCAAGATGAAAATCGTCGTCAAGA
AGAACATATCGAACTCATTGCATCTGAAAACTATGCGAGTCCACGTGTGATGGAAGCGCAAGGTTCACAATTCACTAATA
AATACGCAGAAGGCTATCCAGGTAAACGTTATTACGGTGGTTGTGAGTATGCGGACATTGTGGAACAGTTAGCCATTGAT
CGTGCAAAAGAATTATTTGGTGCAGATTACGTGAATGTTCAACCGCACTCTGGTTCACAAGCGAATGCTGCAGTATATGG
TGCATTGATTAATGCGGGCGATACTATTTTAGGTATGGATTTGGCTCACGGTGGGCACTTAACTCACGGTGCAAAAGTCA
GTTTCTCTGGCAAGATTTATAACTCTGTGCTTTATGGAATCACTGCGGATGGCTTAATTGATTATGAAGATGTTCGTCAA
AAAGCATTAGAATGTAAACCAAAACTTATCGTTGCGGGTTTCTCGGCTTATTCACAAGTTGTGGATTGGGCGAAAATGCG
TGAAATCGCAGATGAAGTTGGTGCATATTTATTTGTGGATATGGCGCATGTAGCAGGATTAATTGCAGCGGGTTTATATC
CAAATCCACTCCCTCATGCACATGTTGTGACAACAACAACCCATAAAACATTGGGCGGTCCGCGTGGTGGTTTAATTCTT
TCATCTTGTGGCGATGAAGAAATCTACAAAAAATTACAATCATCCGTATTCCCTGCAAATCAAGGTGGTCCATTAGTTCA
TATTATTGCGGCAAAAGCAGTTTGCTTTAAAGAAGCATTAGAGCCTCAATATAAAGAATACCAAGCAAATGTAATCAAAA
ATGCAAAAGCAATGGTTGAAGTATTTAAACAACGTGGTTATGACGTTGTGTCAAATGGTACTGAAAACCACTTGTTCTTA
GTAAGTTTCATTAAACAAGGATTAACAGGTAAAGCAGCTGATGCGGCATTAGGCAAAGCAAATATTACCGTGAATAAAAA
TGCAGTACCAAACGATCCGCAAAAACCATTCGTCACTTCTGGCATCCGTGTAGGTACACCATCTGTGACTCGCCGTGGTT
TCAATGAAAATGATGTGCGTGAATTAGCTGGCTGGATGTGTGATGTTTTAGATGCTTTAGGCAAAGAAAATGAAGAACAA
GTGATTGCTGAAACTAAAGAAAAAGTGTTAGCAATTTGTAAACGTCTTCCAGTTTATCCGAAATGA

Upstream 100 bases:

>100_bases
TTTCATTTAAGTGATGAAAATTTAGGAATGAAATTTTAATTAAATTTTTATCCATAAACAGTTAAACTATCTGCCATAAA
TTACATAACAGGAGAACACA

Downstream 100 bases:

>100_bases
TTTATTTTCTTTCGTTGATTATATGTTTAGCGGCGATTAATATCGCCGCTTATTTTTTATGGGAAATTATATGACTTATA
TTGTTGGTTTAACTGGTGGC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAID
RAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQ
KALECKPKLIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLGGPRGGLIL
SSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPQYKEYQANVIKNAKAMVEVFKQRGYDVVSNGTENHLFL
VSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTSGIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQ
VIAETKEKVLAICKRLPVYPK

Sequences:

>Translated_421_residues
MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAID
RAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQ
KALECKPKLIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLGGPRGGLIL
SSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPQYKEYQANVIKNAKAMVEVFKQRGYDVVSNGTENHLFL
VSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTSGIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQ
VIAETKEKVLAICKRLPVYPK
>Mature_421_residues
MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAID
RAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQ
KALECKPKLIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLGGPRGGLIL
SSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPQYKEYQANVIKNAKAMVEVFKQRGYDVVSNGTENHLFL
VSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTSGIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQ
VIAETKEKVLAICKRLPVYPK

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=407, Percent_Identity=45.2088452088452, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI261862350, Length=407, Percent_Identity=45.2088452088452, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI261862348, Length=407, Percent_Identity=45.2088452088452, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI19923315, Length=407, Percent_Identity=45.2088452088452, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI261862346, Length=406, Percent_Identity=44.0886699507389, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=43.8902743142145, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI22547189, Length=389, Percent_Identity=42.4164524421594, Blast_Score=275, Evalue=5e-74,
Organism=Escherichia coli, GI1788902, Length=419, Percent_Identity=74.4630071599045, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=409, Percent_Identity=44.0097799511002, Blast_Score=330, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI25144729, Length=409, Percent_Identity=44.0097799511002, Blast_Score=330, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=42.8927680798005, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6323087, Length=401, Percent_Identity=43.8902743142145, Blast_Score=328, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=46.25, Blast_Score=350, Evalue=9e-97,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=46.25, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45977; Mature: 45977

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCEYADIVEQLAIDRAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEE
LAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQKALECKPKLIVAGFSAYSQV
ECCCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHH
VDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLGGPRGGLIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHCCCCCCCEEE
SSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPQYKEYQANVIKNAKAMVE
ECCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VFKQRGYDVVSNGTENHLFLVSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTS
HHHHCCCEEECCCCCCCEEHHHHHHCCCCCCHHHHHCCCCEEEECCCCCCCCCCCCHHHC
GIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQVIAETKEKVLAICKRLPVYP
CEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
K
C
>Mature Secondary Structure
MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCEYADIVEQLAIDRAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEE
LAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQKALECKPKLIVAGFSAYSQV
ECCCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHH
VDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLGGPRGGLIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHCCCCCCCEEE
SSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPQYKEYQANVIKNAKAMVE
ECCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VFKQRGYDVVSNGTENHLFLVSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTS
HHHHCCCEEECCCCCCCEEHHHHHHCCCCCCHHHHHCCCCEEEECCCCCCCCCCCCHHHC
GIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQVIAETKEKVLAICKRLPVYP
CEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA