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The map label for this gene is pyrR

Identifier: 148827656

GI number: 148827656

Start: 1006363

End: 1006902

Strand: Reverse

Name: pyrR

Synonym: CGSHiGG_05535

Alternate gene names: 148827656

Gene position: 1006902-1006363 (Counterclockwise)

Preceding gene: 148827658

Following gene: 148827655

Centisome position: 53.35

GC content: 36.3

Gene sequence:

>540_bases
ATGGAAAAAATTATTATTGATCATGATCGTTTTCTTCGCACAATTTCGCGTATTTCTCACGAAATTATTGAAAAACATCA
AACCTTAGATGATCTTGTGATTGTTGGGATTAAACGCCGTGGTGCGGAAATTGCAGAATTATTACAACGTCGAGTTGAAG
AGTTAAGTGGTATAAATTTACCTTCAATGGAACTGGATATCACCTTTTATCGCGATGATTTAACTTTGGTTGATCAGGAA
GATAAAATGCCAGTTTATAGTGGTTCATCACAATATTTGAATATTCAAGATAAAACCGTCATTTTGGTTGATGATGTGTT
GTTTACTGGTCGAACCATTCGAGCAGCAATGGATGCGCTTACTGATTTTGGTCGTGCTGCAAAAATTGAATTAGTGATTT
TTGTTGATCGTGGTCATCGTGAATTACCTATTCGTGCTGATTACGTAGGTAAAAATGTGCCAACAAGCCGTGATGAACTT
GTACAAGTTCGCACTGAAAAACAAGATGGCTGTTACGAAGTTGCTATTCTAGGGAAATAA

Upstream 100 bases:

>100_bases
TAGTATAACGAACAAGAAAAATGGTGCAAATGCCGTCGCTTTTTAGGCGTATTTTCTTTATACTTTGTGCATTGAAATAC
TATTGATAAAGCTGGGAGAA

Downstream 100 bases:

>100_bases
ATCTTATCTATTGTGAACCTTCAATAGAATTGTTACTCTAACCAACGTTATTGACTCTTTTTTGGATGAGATGAAAATGA
AAAAATTTGTTTTAAGATCT

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MEKIIIDHDRFLRTISRISHEIIEKHQTLDDLVIVGIKRRGAEIAELLQRRVEELSGINLPSMELDITFYRDDLTLVDQE
DKMPVYSGSSQYLNIQDKTVILVDDVLFTGRTIRAAMDALTDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRDEL
VQVRTEKQDGCYEVAILGK

Sequences:

>Translated_179_residues
MEKIIIDHDRFLRTISRISHEIIEKHQTLDDLVIVGIKRRGAEIAELLQRRVEELSGINLPSMELDITFYRDDLTLVDQE
DKMPVYSGSSQYLNIQDKTVILVDDVLFTGRTIRAAMDALTDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRDEL
VQVRTEKQDGCYEVAILGK
>Mature_179_residues
MEKIIIDHDRFLRTISRISHEIIEKHQTLDDLVIVGIKRRGAEIAELLQRRVEELSGINLPSMELDITFYRDDLTLVDQE
DKMPVYSGSSQYLNIQDKTVILVDDVLFTGRTIRAAMDALTDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRDEL
VQVRTEKQDGCYEVAILGK

Specific function: Displays also a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_HAEI8 (Q4QN84)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248173.1
- HSSP:   P65941
- ProteinModelPortal:   Q4QN84
- SMR:   Q4QN84
- STRING:   Q4QN84
- GeneID:   3429900
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0589
- eggNOG:   COG2065
- HOGENOM:   HBG641958
- OMA:   ILDITLY
- ProtClustDB:   PRK05205
- BioCyc:   HINF281310:NTHI0589-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 20498; Mature: 20498

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIIIDHDRFLRTISRISHEIIEKHQTLDDLVIVGIKRRGAEIAELLQRRVEELSGINL
CCCEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
PSMELDITFYRDDLTLVDQEDKMPVYSGSSQYLNIQDKTVILVDDVLFTGRTIRAAMDAL
CCEEEEEEEEECCEEEEECCCCCCEEECCCCEEEECCCEEEEEECHHHCCHHHHHHHHHH
TDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRDELVQVRTEKQDGCYEVAILGK
HHCCCCEEEEEEEEEECCCCCCCEEHHCCCCCCCCCHHHHEEEECCCCCCEEEEEEECC
>Mature Secondary Structure
MEKIIIDHDRFLRTISRISHEIIEKHQTLDDLVIVGIKRRGAEIAELLQRRVEELSGINL
CCCEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
PSMELDITFYRDDLTLVDQEDKMPVYSGSSQYLNIQDKTVILVDDVLFTGRTIRAAMDAL
CCEEEEEEEEECCEEEEECCCCCCEEECCCCEEEECCCEEEEEECHHHCCHHHHHHHHHH
TDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRDELVQVRTEKQDGCYEVAILGK
HHCCCCEEEEEEEEEECCCCCCCEEHHCCCCCCCCCHHHHEEEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA