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The map label for this gene is tdk [H]

Identifier: 148827655

GI number: 148827655

Start: 1005351

End: 1006286

Strand: Reverse

Name: tdk [H]

Synonym: CGSHiGG_05530

Alternate gene names: 148827655

Gene position: 1006286-1005351 (Counterclockwise)

Preceding gene: 148827656

Following gene: 148827654

Centisome position: 53.32

GC content: 37.07

Gene sequence:

>936_bases
ATGAAAAAATTTGTTTTAAGATCTTTTTTATTGGCTACTTTAGGTTGTGTTGCTTTTACTTCTATGGCACAAGCGGCGGA
ACGTGTTGTCGCAACAGTAGATGGTATTCCTATTTTAGAAAGCCAAGTTCGTGCCAATATGGGTAAAAAAGGTGATCGCC
AAAGTGCGATTGATAAAATTATTGATGATATTTTGGTGCAAAAAGCAGTTCAAGAATCGGGAGTCAAAATTGATCCGCGC
GAAATCGATCATATTGTGGAAGACACTGCGGCAAGAAATGGCTTAACTTATGGTCAATTTTTGGATGCGTTAGATTATCA
AGGCATTTCATTAAATACATTCCGTCAGCAAATTGCCAATCAAATGGTAATGGGAGCTGTACGTAACAAAGCTATTCAAG
AAAGCATTGGTGTAACGCGTGAAGAAGTTGTCGCACTCGGTCAAAAAATGTTAGAAGAAGCGAAAGAAAAGGGTACGGCA
CAGAAAGTTATGGGGAAAGAGTATGAAGTTCGCCATATTTTGTTAAAACTTAATCCATTGTTAAATGATGCTCAAGCAAA
AAAACAATTAGCTAAAATTCGTTCTGATATTATTGCAGGTAAAACAACTTTTGCTGATGCCGCATTAAAATATTCTAAAG
ATTATTTATCGGGTGCGAATGGCGGTAGTTTAGGTTATGCGTTCCCAGAAACTTATGCACCACAGTTTGCGCAAATCGTC
GTGAAAAGTAAACAAGGTGTGATTTCTGCACCATTTAAAACTGAGTTTGGTTGGCATATTTTGGAAGTAACTGGCGTACG
TGATGGCGATCTTACAGCAGAAGCCTACACACAAAAAGCATATGAACGTTTAGTAAATACTCAATTACAAGATGCGACAA
AGGATTGGGTTAAAGCATTGCGTAAAAGAGCGAATATTCAGTATTTTAATAAATAA

Upstream 100 bases:

>100_bases
GAAGTTGCTATTCTAGGGAAATAAATCTTATCTATTGTGAACCTTCAATAGAATTGTTACTCTAACCAACGTTATTGACT
CTTTTTTGGATGAGATGAAA

Downstream 100 bases:

>100_bases
CAAAGTATCAAAAAGAAAGGGGCTTAATTGCCCCTTTTTGTTGTTTTTTTATTTTCTCTTTCTTATAGCTTATGAAGAAA
TTTTTAATTCCGATTTTACT

Product: thymidylate kinase

Products: Isomerized Proline [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKFVLRSFLLATLGCVAFTSMAQAAERVVATVDGIPILESQVRANMGKKGDRQSAIDKIIDDILVQKAVQESGVKIDPR
EIDHIVEDTAARNGLTYGQFLDALDYQGISLNTFRQQIANQMVMGAVRNKAIQESIGVTREEVVALGQKMLEEAKEKGTA
QKVMGKEYEVRHILLKLNPLLNDAQAKKQLAKIRSDIIAGKTTFADAALKYSKDYLSGANGGSLGYAFPETYAPQFAQIV
VKSKQGVISAPFKTEFGWHILEVTGVRDGDLTAEAYTQKAYERLVNTQLQDATKDWVKALRKRANIQYFNK

Sequences:

>Translated_311_residues
MKKFVLRSFLLATLGCVAFTSMAQAAERVVATVDGIPILESQVRANMGKKGDRQSAIDKIIDDILVQKAVQESGVKIDPR
EIDHIVEDTAARNGLTYGQFLDALDYQGISLNTFRQQIANQMVMGAVRNKAIQESIGVTREEVVALGQKMLEEAKEKGTA
QKVMGKEYEVRHILLKLNPLLNDAQAKKQLAKIRSDIIAGKTTFADAALKYSKDYLSGANGGSLGYAFPETYAPQFAQIV
VKSKQGVISAPFKTEFGWHILEVTGVRDGDLTAEAYTQKAYERLVNTQLQDATKDWVKALRKRANIQYFNK
>Mature_311_residues
MKKFVLRSFLLATLGCVAFTSMAQAAERVVATVDGIPILESQVRANMGKKGDRQSAIDKIIDDILVQKAVQESGVKIDPR
EIDHIVEDTAARNGLTYGQFLDALDYQGISLNTFRQQIANQMVMGAVRNKAIQESIGVTREEVVALGQKMLEEAKEKGTA
QKVMGKEYEVRHILLKLNPLLNDAQAKKQLAKIRSDIIAGKTTFADAALKYSKDYLSGANGGSLGYAFPETYAPQFAQIV
VKSKQGVISAPFKTEFGWHILEVTGVRDGDLTAEAYTQKAYERLVNTQLQDATKDWVKALRKRANIQYFNK

Specific function: Chaperone involved in the folding of extracytoplasmic proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786238, Length=233, Percent_Identity=31.7596566523605, Blast_Score=117, Evalue=7e-28,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 34421; Mature: 34421

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFVLRSFLLATLGCVAFTSMAQAAERVVATVDGIPILESQVRANMGKKGDRQSAIDKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
IDDILVQKAVQESGVKIDPREIDHIVEDTAARNGLTYGQFLDALDYQGISLNTFRQQIAN
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHH
QMVMGAVRNKAIQESIGVTREEVVALGQKMLEEAKEKGTAQKVMGKEYEVRHILLKLNPL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHH
LNDAQAKKQLAKIRSDIIAGKTTFADAALKYSKDYLSGANGGSLGYAFPETYAPQFAQIV
HCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VKSKQGVISAPFKTEFGWHILEVTGVRDGDLTAEAYTQKAYERLVNTQLQDATKDWVKAL
HHHCCCCEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKRANIQYFNK
HHHCCCCCCCC
>Mature Secondary Structure
MKKFVLRSFLLATLGCVAFTSMAQAAERVVATVDGIPILESQVRANMGKKGDRQSAIDKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
IDDILVQKAVQESGVKIDPREIDHIVEDTAARNGLTYGQFLDALDYQGISLNTFRQQIAN
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHH
QMVMGAVRNKAIQESIGVTREEVVALGQKMLEEAKEKGTAQKVMGKEYEVRHILLKLNPL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHH
LNDAQAKKQLAKIRSDIIAGKTTFADAALKYSKDYLSGANGGSLGYAFPETYAPQFAQIV
HCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VKSKQGVISAPFKTEFGWHILEVTGVRDGDLTAEAYTQKAYERLVNTQLQDATKDWVKAL
HHHCCCCEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKRANIQYFNK
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proline Imidic Peptide Bonds In Oligopeptides [C]

Specific reaction: Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]