| Definition | Haemophilus influenzae PittGG chromosome, complete genome. |
|---|---|
| Accession | NC_009567 |
| Length | 1,887,192 |
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The map label for this gene is mrcA [H]
Identifier: 148827637
GI number: 148827637
Start: 984333
End: 986927
Strand: Direct
Name: mrcA [H]
Synonym: CGSHiGG_05420
Alternate gene names: 148827637
Gene position: 984333-986927 (Clockwise)
Preceding gene: 148827626
Following gene: 148827638
Centisome position: 52.16
GC content: 41.46
Gene sequence:
>2595_bases ATGCGGATCGCAAAATTAATATTAAACACCCTATTAACTTTATGTATTTTAGGTTTAGTAGCAGGCGGAATGTTGTATTT CCACTTAAAATCTGAATTGCCCTCAGTAGAAACATTAAAAACCGTTGAATTACAGCAACCAATGCAGATTTATACGGCAG ACGGTAAATTAATTGGCGAAGTGGGTGAGCAACGCCGTATTCCAGTGAAATTAGCCGATGTTCCACAACGCTTAATTGAC GCATTTTTAGCTACGGAAGATAGCCGCTTTTACGATCATCACGGATTAGACCCTATCGGCATTGCCCGTGCATTATTTGT CGCAGTGAGTAATGGCGGTGCATCACAAGGCGCAAGTACGATTACTCAACAATTAGCGCGTAACTTTTTCTTAACCTCAG AAAAAACCATTATTCGTAAAGCTCGTGAAGCCGTGCTTGCGGTAGAAATTGAAAATACCCTCAACAAACAAGAAATCTTA GAGCTTTATTTAAACAAAATCTTTTTAGGCTATCGTTCTTATGGTGTTGCAGCGGCAGCACAAACCTATTTCGGTAAATC ATTGAATGAATTGACCTTATCGGAAATGGCGATTATTGCTGGTTTACCTAAAGCACCTTCAACAATGAATCCGCTTTATT CTTTAAAACGTTCAGAAGAACGCCGCAATGTGGTGCTAAGCCGTATGTTAGATGAAAAATACATCAGCAAAGAAGAATAT GATGCTGCATTGAAAGAGCCGATTGTGGCGAGTTATCACGGCGCAAAATTTGAATTTCGAGCCGATTATGTCACTGAAAT GGTGCGTCAAGAAATGGTGCGTCGTTTTGGTGAAGAAAATGCTTACACCAGTGGTTATAAAGTATTTACCACTGTACTTT CAAAAGACCAAGCCGAAGCCCAAAAAGCTGTGCGTAATAACTTGATTGATTACGATATGCGTCACGGTTATCGCGGTGGC GCGCCATTATGGCAAAAAAATGAAGCAGCTTGGGACAATGATCGCATTGTCGGTTTTCTACGCAAACTACCTGATTCAGA GCCATTTATTCCTGCGGCAGTGATTGGAATTGCAAAAGGCGGTGCTGATATATTGCTTGCCTCTGGAGAAAAAATGACCT TATCAACCAATGCAATGCGTTGGACAGGCAGAAGCAATCCTGTGAAAGTCGGCGAGCAAATTTGGATTCGTCAGCGTGCT AATGGGGAATGGCAATTAGGACAAATTCCCGCAGCAAATTCAGCATTAGTTTCTCTTAATTCAGATAATGGTGCGATTGA AGCAGTGGTGGGTGGCTTTAGCTATGAACAAAGTAAATTCAATCGAGCCACACAATCTTTAGTTCAAGTGGGTTCTTCTA TTAAACCATTTATTTACGCGGCAGCATTAGAAAAAGGCTTAACGCTTTCTAGTGTATTACAAGACAGCCCGATTTCTATT CAAAAACCGGGACAAAAAATGTGGCAACCGAAAAACTCGCCTGATCGTTATGATGGTCCAATGCGTTTACGCGTAGGATT AGGTCAATCCAAAAATATGATTGCTATTCGCGCTATCCAAACGGCAGGTATTGATTTCACAGCAGAATTTTTACAACGTT TTGGTTTTAAACGTGATCAATATTTTGCTAGCGAAGCCTTAGCACTTGGTGCTGCCTCTTTCACGCCATTAGAAATGGCG CGAGCTTATGCCGTGTTTGATAATGGCGGTTTCCTCATTGAACCTTATATCATTGAAAAAATTCAAGATAACACGGGTAA AGACTTATTTATTGCAAACCCTAAAATTGCTTGTATTGAATGTAATGATATACCTGTAATTTATGGTGAAACCAAAGACA AAATCAACGGCTTTGCCAATATTCCTTTAGGCGAGAGTGCCTTAAAACCAACAGATGACAGCACCAATGGCGAAGAATTA GATCAACAACCTGAAACTGTGCCTGAACTGCCAGAATTACAGTCAAATTTCACCGCACTTAAGGAAGATGCAATTGATTT AATGGCCGCAGCAAAAAATGCCTCGTCGAAAATAGAATATGCGCCACGTGTCATTAGTGGCGAACTTGCTTTTCTCATTC GTAGTGCCTTAAATACGGCGATTTATGGCGAACAAGGTTTAGACTGGAAAGGCACCAGCTGGCGCATTGCACAAAGCATT AAACGTAGCGATATAGGCGGTAAAACAGGTACCACCAACAGTTCAAAAGTGGCTTGGTATGCGGGATTTGGTGCAAACTT AGTAACCACAACTTATGTCGGGTTTGATGATAACAAACGTGTACTTGGGCGCGGAGAAGCAGGTGCAAAAACAGCCATGC CTGCTTGGATCACTTATATGAAAACGGCTTTGAGTGATAAGCCAGAACGTAAATTGCCACTGCCGCCAAAAATTGTGGAA AAAAGCATTGATACTTTGACAGGTTTGCTTTCTCCGAACGGTGGACGCAAAGAATATTTTATCGTGGGAACAGAACCGAC ACGTACCTATCTTTCGGAAATGCAAGAGCGTGGTTATTACGTTCCTACAGAGTTACAGCAACGCTTAAATAATGAAGGCA ATACGCCAGCGACGCAACCACAAGAACTCTTCTAA
Upstream 100 bases:
>100_bases ATATTCTTTCCTATTCTTTAAAGGCTGAATCTTTTATACTTAACAACCAAATCATAGGTCTCCTGACAAGAATATTCATT AACGAAGCGAGAATTTTACG
Downstream 100 bases:
>100_bases AAATGACCGCACTTTAGTGTGAAATCGGGCGAGTCAATTGGCTCGCCTTCGTTATTAAACAAAGGATATATTATGCTGAG TTATCGTCACTCATTTCATG
Product: penicillin-binding protein 1A
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-binding protein A; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 864; Mature: 864
Protein sequence:
>864_residues MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGEVGEQRRIPVKLADVPQRLID AFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGASTITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEIL ELYLNKIFLGYRSYGVAAAAQTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEAQKAVRNNLIDYDMRHGYRGG APLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIAKGGADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIRQRA NGEWQLGQIPAANSALVSLNSDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNMIAIRAIQTAGIDFTAEFLQRFGFKRDQYFASEALALGAASFTPLEMA RAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIECNDIPVIYGETKDKINGFANIPLGESALKPTDDSTNGEEL DQQPETVPELPELQSNFTALKEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYMKTALSDKPERKLPLPPKIVE KSIDTLTGLLSPNGGRKEYFIVGTEPTRTYLSEMQERGYYVPTELQQRLNNEGNTPATQPQELF
Sequences:
>Translated_864_residues MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGEVGEQRRIPVKLADVPQRLID AFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGASTITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEIL ELYLNKIFLGYRSYGVAAAAQTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEAQKAVRNNLIDYDMRHGYRGG APLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIAKGGADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIRQRA NGEWQLGQIPAANSALVSLNSDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNMIAIRAIQTAGIDFTAEFLQRFGFKRDQYFASEALALGAASFTPLEMA RAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIECNDIPVIYGETKDKINGFANIPLGESALKPTDDSTNGEEL DQQPETVPELPELQSNFTALKEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYMKTALSDKPERKLPLPPKIVE KSIDTLTGLLSPNGGRKEYFIVGTEPTRTYLSEMQERGYYVPTELQQRLNNEGNTPATQPQELF >Mature_864_residues MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGEVGEQRRIPVKLADVPQRLID AFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGASTITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEIL ELYLNKIFLGYRSYGVAAAAQTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEAQKAVRNNLIDYDMRHGYRGG APLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIAKGGADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIRQRA NGEWQLGQIPAANSALVSLNSDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNMIAIRAIQTAGIDFTAEFLQRFGFKRDQYFASEALALGAASFTPLEMA RAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIECNDIPVIYGETKDKINGFANIPLGESALKPTDDSTNGEEL DQQPETVPELPELQSNFTALKEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYMKTALSDKPERKLPLPPKIVE KSIDTLTGLLSPNGGRKEYFIVGTEPTRTYLSEMQERGYYVPTELQQRLNNEGNTPATQPQELF
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=867, Percent_Identity=52.7104959630911, Blast_Score=865, Evalue=0.0, Organism=Escherichia coli, GI1786343, Length=276, Percent_Identity=35.5072463768116, Blast_Score=151, Evalue=2e-37, Organism=Escherichia coli, GI1788867, Length=237, Percent_Identity=33.7552742616034, Blast_Score=124, Evalue=2e-29, Organism=Escherichia coli, GI1789601, Length=126, Percent_Identity=42.0634920634921, Blast_Score=90, Evalue=6e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 95429; Mature: 95429
Theoretical pI: Translated: 7.52; Mature: 7.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGE CHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCCCHHHHHHHHCCCCEEEECCCHHHHH VGEQRRIPVKLADVPQRLIDAFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGAST CCCCCCCCEEHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHEECCCCCCCHHHH ITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEILELYLNKIFLGYRSYGVAAAA HHHHHHHHHCCCCHHHHHHHHHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH QTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY HHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEA HHHHHCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHH QKAVRNNLIDYDMRHGYRGGAPLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIAKG HHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHEEECC GADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIRQRANGEWQLGQIPAANSALVSLN CCEEEEECCCEEEEECCCEEECCCCCCCCCCHHEEEEECCCCCEEECCCCCCCCEEEEEC SDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI CCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCCCC QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNMIAIRAIQTAGIDFTAEFLQRFGFKRDQ CCCCHHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCHHH YFASEALALGAASFTPLEMARAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIE HHHHHHHHHCCCCCCHHHHHHEEEEEECCCEEECHHHHHHHCCCCCCEEEEECCCEEEEE CNDIPVIYGETKDKINGFANIPLGESALKPTDDSTNGEELDQQPETVPELPELQSNFTAL ECCEEEEECCCHHHCCCEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHH KEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI HHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYM HHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHH KTALSDKPERKLPLPPKIVEKSIDTLTGLLSPNGGRKEYFIVGTEPTRTYLSEMQERGYY HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCC VPTELQQRLNNEGNTPATQPQELF CCHHHHHHHCCCCCCCCCCCHHCC >Mature Secondary Structure MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGE CHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCCCHHHHHHHHCCCCEEEECCCHHHHH VGEQRRIPVKLADVPQRLIDAFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGAST CCCCCCCCEEHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHEECCCCCCCHHHH ITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEILELYLNKIFLGYRSYGVAAAA HHHHHHHHHCCCCHHHHHHHHHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH QTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY HHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEA HHHHHCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHH QKAVRNNLIDYDMRHGYRGGAPLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIAKG HHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHEEECC GADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIRQRANGEWQLGQIPAANSALVSLN CCEEEEECCCEEEEECCCEEECCCCCCCCCCHHEEEEECCCCCEEECCCCCCCCEEEEEC SDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI CCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCCCC QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNMIAIRAIQTAGIDFTAEFLQRFGFKRDQ CCCCHHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCHHH YFASEALALGAASFTPLEMARAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIE HHHHHHHHHCCCCCCHHHHHHEEEEEECCCEEECHHHHHHHCCCCCCEEEEECCCEEEEE CNDIPVIYGETKDKINGFANIPLGESALKPTDDSTNGEELDQQPETVPELPELQSNFTAL ECCEEEEECCCHHHCCCEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHH KEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI HHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYM HHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHH KTALSDKPERKLPLPPKIVEKSIDTLTGLLSPNGGRKEYFIVGTEPTRTYLSEMQERGYY HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCC VPTELQQRLNNEGNTPATQPQELF CCHHHHHHHCCCCCCCCCCCHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 1916268; 7542800; 7592463; 10675023 [H]