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The map label for this gene is hup

Identifier: 148827627

GI number: 148827627

Start: 977385

End: 977657

Strand: Reverse

Name: hup

Synonym: CGSHiGG_05370

Alternate gene names: 148827627

Gene position: 977657-977385 (Counterclockwise)

Preceding gene: 148827628

Following gene: 148827625

Centisome position: 51.8

GC content: 38.1

Gene sequence:

>273_bases
ATGAACAAAACAGATTTAATTGATGCAATTGCAAACGCTGCAGAGTTAAACAAAAAACAAGCTAAAGCAGCGTTAGAAGC
GACTTTAGATGCAATTACTGCAAGCCTAAAAGAAGGTGAGCCTGTACAATTAATCGGTTTCGGTACATTTAAAGTAAATG
AACGTGCTGCTCGTACTGGTCGCAACCCACAAACTGGTGCTGAAATTCAAATCGCAGCATCTAAAGTGCCAGCATTTGTA
TCTGGTAAAGCATTAAAAGATGCAATCAAATAA

Upstream 100 bases:

>100_bases
TTCATCTCAAGTTAGATTATCCTTTGCACAGTTTTTGCGACAAATTCGCAAAGATACTTTTAAAGAATCAAACTTTTTAT
TTAACAGAAGGTACAAATTT

Downstream 100 bases:

>100_bases
TTGATAACATCAATGAAATGAAGCCCTGTCGATTGCGCAGGGTTTTTTTTATTGTGTAAACGCGTGGCAAATGTAAAAAC
AAACTTAGTAATAGAATAAA

Product: DNA-binding protein HU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MNKTDLIDAIANAAELNKKQAKAALEATLDAITASLKEGEPVQLIGFGTFKVNERAARTGRNPQTGAEIQIAASKVPAFV
SGKALKDAIK

Sequences:

>Translated_90_residues
MNKTDLIDAIANAAELNKKQAKAALEATLDAITASLKEGEPVQLIGFGTFKVNERAARTGRNPQTGAEIQIAASKVPAFV
SGKALKDAIK
>Mature_90_residues
MNKTDLIDAIANAAELNKKQAKAALEATLDAITASLKEGEPVQLIGFGTFKVNERAARTGRNPQTGAEIQIAASKVPAFV
SGKALKDAIK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family

Homologues:

Organism=Escherichia coli, GI1790433, Length=90, Percent_Identity=78.8888888888889, Blast_Score=141, Evalue=7e-36,
Organism=Escherichia coli, GI1786644, Length=89, Percent_Identity=64.0449438202247, Blast_Score=114, Evalue=1e-27,
Organism=Escherichia coli, GI1787141, Length=88, Percent_Identity=36.3636363636364, Blast_Score=72, Evalue=8e-15,
Organism=Escherichia coli, GI1788005, Length=90, Percent_Identity=34.4444444444444, Blast_Score=64, Evalue=2e-12,

Paralogues:

None

Copy number: 1380 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): DBH_HAEIN (P43722)

Other databases:

- EMBL:   L42023
- PIR:   E64067
- RefSeq:   NP_438591.2
- ProteinModelPortal:   P43722
- SMR:   P43722
- GeneID:   950715
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0430
- TIGR:   HI_0430
- HOGENOM:   HBG705085
- OMA:   MNSITYE
- ProtClustDB:   CLSK870593
- BioCyc:   HINF71421:HI_0430-MONOMER
- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992
- Gene3D:   G3DSA:4.10.520.10
- PRINTS:   PR01727
- SMART:   SM00411

Pfam domain/function: PF00216 Bac_DNA_binding; SSF47729 IHF_like_DNA_bnd

EC number: NA

Molecular weight: Translated: 9421; Mature: 9421

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTDLIDAIANAAELNKKQAKAALEATLDAITASLKEGEPVQLIGFGTFKVNERAARTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECEEEECCHHHHCC
RNPQTGAEIQIAASKVPAFVSGKALKDAIK
CCCCCCCEEEEECCCCCCHHCCHHHHHHCC
>Mature Secondary Structure
MNKTDLIDAIANAAELNKKQAKAALEATLDAITASLKEGEPVQLIGFGTFKVNERAARTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECEEEECCHHHHCC
RNPQTGAEIQIAASKVPAFVSGKALKDAIK
CCCCCCCEEEEECCCCCCHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800