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The map label for this gene is hisS [H]

Identifier: 148827508

GI number: 148827508

Start: 870707

End: 871978

Strand: Direct

Name: hisS [H]

Synonym: CGSHiGG_04655

Alternate gene names: 148827508

Gene position: 870707-871978 (Clockwise)

Preceding gene: 148827507

Following gene: 148827509

Centisome position: 46.14

GC content: 39.54

Gene sequence:

>1272_bases
GTGGCAAAAACAATTCAAGCAATTCGTGGTATGAACGATTGCGCCCCAACAGAATCTCCATTATGGCAATGGATTGAAGC
ACAAGTACGCAATGTATTAAATAGTTATGGCTATTCGGAAGTGCGTATGCCAATTGTAGAAAGTACGCCATTGTTTGCGC
GTGCAATCGGCGAAGTAACTGATGTTGTTTCAAAAGAAATGTACACATTTTGGGATAACGATGAACAATTAACCTTACGC
CCTGAAGGCACAGCAGGTTGTGTGCGAGCAGCCATTGAACACGGTTGGATCTATAATAATGAACAACGCTTATGGTATAT
CGGGCCAATGTTCCGTCACGAACGTCCGCAAAAAGGGCGTTACCGTCAATTCCATCAAGCAGGTGTTGAGGTATTCGGTA
TTGCAAATCCAGAAATCGATGCAGAATTAATCATACTTACCTATCGTTTATGGAAAGCGTTAGGTATCGATCAACATGTT
ACACTTCAACTTAACTCAATTGGTTCTTTAGAAGCACGCGCAAATTATCGTTCTGCGTTGGTTGGATTCTTAGAAAACCA
TCAAGATTTAATGAGCGATGAAGAAAAAGATCGCTTGGTAAAAAATCCATTGCGTATTTTGGATACCAAAAATCCAGAAT
TACAAAAAGTATTGGATAACGCGCCAAAATTACTTGATTATCTAGATGATGAAAGCCGTGAGCATTTTGAACAATTATGT
TCATTATTAGATGCTGTTGATATTCAATATGAAATTAATCCTAAACTCGTGCGTGGTTTAGATTATTACAACAAAACTGT
ATTTGAATGGGTAACCTCTGCTCTTGGTGCACAAGGTACCGTGTGTGGCGGCGGTCGTTATGACGGTTTAGTGGAACAAC
TTGGCGGACACGCAACGCCAAGCATCGGATTTGCGATGGGATTAGAGCGTTTAGTCTTGTTGGTACAAGAAGTTAATCCA
AATGTTCCTGTTAAAAGTGCGGTGGATATTTATGTTGTTTATCAAGGCGAAGGCACAACATTAGCCGCTTTTGAATTAGC
GGAAAAAGTACGCTCGGAATTACCGCACTTAAATACCATGTTGCACTGCTCTGGTGGCAATTTTAAAAAACAATTTAAAC
GTGCAGATAAATCTGGTGCAACATTAGCATTAGTTATCGGCGAAAGCGAAGTCCAAAATAAACAAGTCGTTGTTAAACAC
TTACAAGGTGGTGCAGATCAGCAAACCTTAGATTTAGTGAATGTAATCGACTATATTCAAACTCAATTTTAA

Upstream 100 bases:

>100_bases
GCGTTTTGATAACGAAGATATAGTGAACCAATTAGAAGCAAAAATTCGTGCGAAAGTCGCACGACAAGATCCAAAAAACA
GAATTATTTAAGGAAAGCGC

Downstream 100 bases:

>100_bases
TTTAAAAGGGGAAAAACATGGCTTATTCCATTGAAGAAGAACAAGAGATTAACCAGTTGAAAGAGTGGTGGAAAGAGAAT
GGCAAAACAATTATTGTCGC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MAKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLR
PEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGRYRQFHQAGVEVFGIANPEIDAELIILTYRLWKALGIDQHV
TLQLNSIGSLEARANYRSALVGFLENHQDLMSDEEKDRLVKNPLRILDTKNPELQKVLDNAPKLLDYLDDESREHFEQLC
SLLDAVDIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATPSIGFAMGLERLVLLVQEVNP
NVPVKSAVDIYVVYQGEGTTLAAFELAEKVRSELPHLNTMLHCSGGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKH
LQGGADQQTLDLVNVIDYIQTQF

Sequences:

>Translated_423_residues
MAKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLR
PEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGRYRQFHQAGVEVFGIANPEIDAELIILTYRLWKALGIDQHV
TLQLNSIGSLEARANYRSALVGFLENHQDLMSDEEKDRLVKNPLRILDTKNPELQKVLDNAPKLLDYLDDESREHFEQLC
SLLDAVDIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATPSIGFAMGLERLVLLVQEVNP
NVPVKSAVDIYVVYQGEGTTLAAFELAEKVRSELPHLNTMLHCSGGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKH
LQGGADQQTLDLVNVIDYIQTQF
>Mature_422_residues
AKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLRP
EGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGRYRQFHQAGVEVFGIANPEIDAELIILTYRLWKALGIDQHVT
LQLNSIGSLEARANYRSALVGFLENHQDLMSDEEKDRLVKNPLRILDTKNPELQKVLDNAPKLLDYLDDESREHFEQLCS
LLDAVDIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATPSIGFAMGLERLVLLVQEVNPN
VPVKSAVDIYVVYQGEGTTLAAFELAEKVRSELPHLNTMLHCSGGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKHL
QGGADQQTLDLVNVIDYIQTQF

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=405, Percent_Identity=68.8888888888889, Blast_Score=583, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI71993693, Length=478, Percent_Identity=24.4769874476987, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71993686, Length=478, Percent_Identity=24.6861924686192, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325290, Length=471, Percent_Identity=22.9299363057325, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47655; Mature: 47524

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVT
CCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHH
DVVSKEMYTFWDNDEQLTLRPEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGR
HHHHHHHHEEECCCCEEEECCCCCHHHHHHHHHHCCEEECCCEEEEECCHHHCCCCCCCH
YRQFHQAGVEVFGIANPEIDAELIILTYRLWKALGIDQHVTLQLNSIGSLEARANYRSAL
HHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
VGFLENHQDLMSDEEKDRLVKNPLRILDTKNPELQKVLDNAPKLLDYLDDESREHFEQLC
HHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHHHH
SLLDAVDIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATP
HHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHCCCCCC
SIGFAMGLERLVLLVQEVNPNVPVKSAVDIYVVYQGEGTTLAAFELAEKVRSELPHLNTM
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHCCCCCEE
LHCSGGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKHLQGGADQQTLDLVNVIDYIQ
EEECCCCHHHHHHHCCCCCCEEEEEECCCHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
TQF
HCC
>Mature Secondary Structure 
AKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVT
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHH
DVVSKEMYTFWDNDEQLTLRPEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGR
HHHHHHHHEEECCCCEEEECCCCCHHHHHHHHHHCCEEECCCEEEEECCHHHCCCCCCCH
YRQFHQAGVEVFGIANPEIDAELIILTYRLWKALGIDQHVTLQLNSIGSLEARANYRSAL
HHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
VGFLENHQDLMSDEEKDRLVKNPLRILDTKNPELQKVLDNAPKLLDYLDDESREHFEQLC
HHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHHHH
SLLDAVDIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATP
HHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHCCCCCC
SIGFAMGLERLVLLVQEVNPNVPVKSAVDIYVVYQGEGTTLAAFELAEKVRSELPHLNTM
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHCCCCCEE
LHCSGGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKHLQGGADQQTLDLVNVIDYIQ
EEECCCCHHHHHHHCCCCCCEEEEEECCCHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
TQF
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA