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The map label for this gene is galE [H]

Identifier: 148827496

GI number: 148827496

Start: 856104

End: 857120

Strand: Reverse

Name: galE [H]

Synonym: CGSHiGG_04565

Alternate gene names: 148827496

Gene position: 857120-856104 (Counterclockwise)

Preceding gene: 148827497

Following gene: 148827495

Centisome position: 45.42

GC content: 38.74

Gene sequence:

>1017_bases
ATGGCCATTTTAGTGACAGGTGGCGCCGGTTATATCGGTTCTCACACAGTTGTAGAATTATTAAATGCTGGCAAAGAGGT
GGTGGTATTAGATAATCTTTGCAATTCATCGCCAAAATCCCTTGAGCGTGTAAAACAAATTACAGGCAAAGAAGCAAAGT
TTTATGAAGGCGATATTTTAGATCGTGCTTTGTTACAAAAAATTTTTGCAGAAAATGAGATTAACTCGGTTATTCACTTT
GCAGGGTTAAAAGCCGTAGGGGAAAGTGTTCAAAAGCCGACAGAATATTACATGAACAATGTCGCTGGCACCCTTGTATT
AATTCAAGAAATGAAAAAAGCGGGTGTTTGGAACTTTGTATTTAGCTCATCTGCAACGGTTTACGGCGATCCAAAAATTA
TTCCAATTACAGAGGATTGTGAGGTCGGCGGTACAACCAATCCTTATGGTACATCTAAATATATGGTTGAGCAGATTTTA
TGCGATACAGCAAAAGCGGAACCAAAATTTAGCATGACTATCTTGCGTTATTTTAATCCAGTTGGGGCGCATGAAAGTGG
CTTGATTGGTGAAGATCCAAATGGTATTCCAAATAATTTATTACCTTATATTAGCCAAGTTGCTATCGGTAAATTAGCAC
AACTTTCTGTATTTGGTAGTGATTACGACACTCATGATGGAACAGGTGTGCGTGATTATATTCATGTAGTGGATTTAGCT
GTGGGGCATTTAAAAGCGCTTCAACGTCATGAAAATGACGCTGGCTTACATATTTATAACCTTGGTACGGGCCATGGTTA
TTCCGTATTAGATATGGTAAAAGCCTTTGAAAAAGCCAACAATATTACAATTGCATATAAACTTGTAGAACGCCGCGCTG
GCGATATTGCTACTTGCTATTCTGATCCTAGTTTAGCTGCAAAAGAGCTTGGTTGGGTGGCAGAACGTGGTCTTGAAAAA
ATGATGCAAGACACGTGGAACTGGCAGAAAAATAATCCAAAAGGGTATAGAGATTAA

Upstream 100 bases:

>100_bases
TTTTTAGCAACAGGTTTTTTATTTTATTGAAAATCACCATTCTTACCACACAAAATAGTGATATAATTTTTTAGTCTCAA
TAATTAACAAGGAAATCATT

Downstream 100 bases:

>100_bases
TATTCTCTAATATTTGTTTTTCTTTTTTAGGAAGAAGAATGCTAAACATTAGGGGAATGATTAAAAATCCCCTAATTTTT
ACAAAAATCCTTTAATTGAA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MAILVTGGAGYIGSHTVVELLNAGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHF
AGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQIL
CDTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRAGDIATCYSDPSLAAKELGWVAERGLEK
MMQDTWNWQKNNPKGYRD

Sequences:

>Translated_338_residues
MAILVTGGAGYIGSHTVVELLNAGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHF
AGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQIL
CDTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRAGDIATCYSDPSLAAKELGWVAERGLEK
MMQDTWNWQKNNPKGYRD
>Mature_337_residues
AILVTGGAGYIGSHTVVELLNAGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHFA
GLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILC
DTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLAV
GHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRAGDIATCYSDPSLAAKELGWVAERGLEKM
MQDTWNWQKNNPKGYRD

Specific function: By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae [H]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=59.1176470588235, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=59.1176470588235, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=59.1176470588235, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI7657641, Length=348, Percent_Identity=26.1494252873563, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=57.6923076923077, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788353, Length=367, Percent_Identity=26.158038147139, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI48994969, Length=364, Percent_Identity=27.1978021978022, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=57.9710144927536, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=57.6368876080692, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17568069, Length=283, Percent_Identity=27.5618374558304, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=344, Percent_Identity=53.7790697674419, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=59.3567251461988, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37069; Mature: 36937

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVTGGAGYIGSHTVVELLNAGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDIL
CEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHH
DRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILCDTAKAEPKFSMTILRYFNP
ECCCCEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
VGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHH
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRAGDIATCY
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCEEEEC
SDPSLAAKELGWVAERGLEKMMQDTWNWQKNNPKGYRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AILVTGGAGYIGSHTVVELLNAGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDIL
EEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHH
DRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILCDTAKAEPKFSMTILRYFNP
ECCCCEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
VGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHH
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRAGDIATCY
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCEEEEC
SDPSLAAKELGWVAERGLEKMMQDTWNWQKNNPKGYRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1956282; 7542800 [H]