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The map label for this gene is adk [H]

Identifier: 148827494

GI number: 148827494

Start: 853956

End: 854600

Strand: Reverse

Name: adk [H]

Synonym: CGSHiGG_04555

Alternate gene names: 148827494

Gene position: 854600-853956 (Counterclockwise)

Preceding gene: 148827495

Following gene: 148827476

Centisome position: 45.28

GC content: 39.53

Gene sequence:

>645_bases
ATGAAAATTATTCTTTTAGGTGCACCGGGTGCAGGTAAAGGCACTCAAGCACAATTTATTATGAACAAATTTGGTATCCC
GCAAATTTCAACTGGTGATATGTTCCGTGCTGCAATCAAAGCGGGGACTGAACTTGGCAAACAAGCTAAAGCATTAATGG
ATGAAGGTAAATTAGTGCCAGATGAATTAACCGTTGCCCTTGTAAAAGATCGTATTGCTCAAGCTGACTGCACAAATGGT
TTCTTGTTAGATGGTTTCCCTCGTACTATTCCACAAGCGGATGCACTGAAAGATTCAGGTGTTAAAATTGACTTTGTTTT
AGAATTTGATGTGCCAGACGAAGTGATTGTTGAACGTATGAGTGGCCGTCGCGTACACCAAGCGTCTGGCCGTTCTTACC
ACATCGTTTATAATCCACCAAAAGTGGAAGGTAAAGATGATGTAACAGGCGAAGATTTAATTATTCGTGCAGACGATAAA
CCAGAAACTGTATTAGATCGTTTAGCCGTATATCATAAACAAACTAGCCCATTAATTGATTATTACCAAGCAGAAGCGAA
AGCGGGGAATACTCAATATTTCCGTTTAGACGGTACACAAAAAGTAGAAGAAGTTAGCCAAGAGTTAGATAAAATCTTAG
GCTAA

Upstream 100 bases:

>100_bases
GACCAGCTCAGTATAAAAGTGCGGTAAAAATTATAAAAAATTTGACCGCACTATGCTTTATCAGTATCTTAATCACGTTT
TGTATTAATGGAGATTTTTT

Downstream 100 bases:

>100_bases
AAATAATCTAAAAATTAACCGCACTTTAGAAAATATAATTAATCTGCACCTTAAAGGCTGAATAAATCAGCGAATTAAAG
TGCAGATTTTTTTATAAACT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMFRAAIKAGTELGKQAKALMDEGKLVPDELTVALVKDRIAQADCTNG
FLLDGFPRTIPQADALKDSGVKIDFVLEFDVPDEVIVERMSGRRVHQASGRSYHIVYNPPKVEGKDDVTGEDLIIRADDK
PETVLDRLAVYHKQTSPLIDYYQAEAKAGNTQYFRLDGTQKVEEVSQELDKILG

Sequences:

>Translated_214_residues
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMFRAAIKAGTELGKQAKALMDEGKLVPDELTVALVKDRIAQADCTNG
FLLDGFPRTIPQADALKDSGVKIDFVLEFDVPDEVIVERMSGRRVHQASGRSYHIVYNPPKVEGKDDVTGEDLIIRADDK
PETVLDRLAVYHKQTSPLIDYYQAEAKAGNTQYFRLDGTQKVEEVSQELDKILG
>Mature_214_residues
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMFRAAIKAGTELGKQAKALMDEGKLVPDELTVALVKDRIAQADCTNG
FLLDGFPRTIPQADALKDSGVKIDFVLEFDVPDEVIVERMSGRRVHQASGRSYHIVYNPPKVEGKDDVTGEDLIIRADDK
PETVLDRLAVYHKQTSPLIDYYQAEAKAGNTQYFRLDGTQKVEEVSQELDKILG

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=187, Percent_Identity=50.8021390374332, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI4502013, Length=187, Percent_Identity=50.8021390374332, Blast_Score=200, Evalue=6e-52,
Organism=Homo sapiens, GI19923437, Length=206, Percent_Identity=46.6019417475728, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=41.8478260869565, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=41.8478260869565, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=41.8478260869565, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=41.8478260869565, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=30.7692307692308, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=30.5936073059361, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI22749187, Length=140, Percent_Identity=31.4285714285714, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI28144897, Length=208, Percent_Identity=26.4423076923077, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI28144899, Length=208, Percent_Identity=26.4423076923077, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=71.4953271028037, Blast_Score=326, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=41.743119266055, Blast_Score=187, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=190, Percent_Identity=36.3157894736842, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=33.6898395721925, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=28.3720930232558, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17533833, Length=185, Percent_Identity=27.027027027027, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=188, Percent_Identity=48.936170212766, Blast_Score=198, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=187, Percent_Identity=44.9197860962567, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=210, Percent_Identity=30.4761904761905, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=47.196261682243, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI17737899, Length=202, Percent_Identity=44.0594059405941, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24645822, Length=202, Percent_Identity=44.0594059405941, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=30.2325581395349, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=30.2325581395349, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17647141, Length=182, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24663208, Length=212, Percent_Identity=27.8301886792453, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23508; Mature: 23508

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMFRAAIKAGTELGKQAKALMDEGKLVP
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DELTVALVKDRIAQADCTNGFLLDGFPRTIPQADALKDSGVKIDFVLEFDVPDEVIVERM
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHCCCCCEEEEEEEECCCHHHHHHHH
SGRRVHQASGRSYHIVYNPPKVEGKDDVTGEDLIIRADDKPETVLDRLAVYHKQTSPLID
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHH
YYQAEAKAGNTQYFRLDGTQKVEEVSQELDKILG
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMFRAAIKAGTELGKQAKALMDEGKLVP
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DELTVALVKDRIAQADCTNGFLLDGFPRTIPQADALKDSGVKIDFVLEFDVPDEVIVERM
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHCCCCCEEEEEEEECCCHHHHHHHH
SGRRVHQASGRSYHIVYNPPKVEGKDDVTGEDLIIRADDKPETVLDRLAVYHKQTSPLID
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHH
YYQAEAKAGNTQYFRLDGTQKVEEVSQELDKILG
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA