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The map label for this gene is dapA [H]

Identifier: 148827398

GI number: 148827398

Start: 753052

End: 753948

Strand: Direct

Name: dapA [H]

Synonym: CGSHiGG_03970

Alternate gene names: 148827398

Gene position: 753052-753948 (Clockwise)

Preceding gene: 148827389

Following gene: 148827399

Centisome position: 39.9

GC content: 37.57

Gene sequence:

>897_bases
ATGTCAGCGCAAAATTCTTTATTTTCGGGTAGCATAGTTGCCCTTGTTACGCCAATGAATCATTATGGCGAAGTCGATTT
TTCCTGTTTAGAAAAATTAGTAGAACACCACATTGAAGCTGGTTCTAATGCGCTTGTTTCTGTGGGTACAACGGGAGAAT
CCGCCACGCTAAGTATTGAAGAAAATGTAAAAGTCATTGAAAAGACTGTTGAATTTGCCAAAGGACGTATTCCTATTATT
GCGGGAGCGGGTGCAAATGCGACAAGTGAAGCAATTACAATGACTAAATTATTACGAGACAGTGGCGTAGCAGGATGTTT
ATCTGTTGTGCCTTATTATAATAAACCAACCCAAGAGGGAATATATCAACACTTTAAAGCCATTGCGGAATGTACTAATT
TACCACAGATTCTTTATAACGTTCCTAGTCGCACAGGCAGTGATATGAAACCAGAAACGGTTGCTCGTTTAGCTGAAATT
GAAAATATTGTAGGTATTAAAGAAGCAACGGGAGATGTGAGCCGAATAGTTAAAATTAAGCAGCTTGCTGGTAAAAATTT
TATTGTTTTAAGTGGTGATGATGCAACAGGATTAGAAGCAATAAAATTAGGTGCTGAGGGAGTAATATCAGTAACAAATA
ACATTGCAGCAAAAGATATGGCTGATATGTACCGTTATGCACTCGTGGGAGATTTTGATAAAGCGGAAGAAATTAATGCT
CGTTTAATGCGTTTACATCACGACCTATTCATTGAATCCAATCCAATTCCAGTGAAGTGGGCAGCTTATCGCTTAGGCTT
AATTAAATCGTCACATTTACGTTTGCCACTTACGACACTTAGTGAAGAAATTCAACCAAAAGTAGAAGATGCACTAAAAA
TTGCAGGATTATTATAA

Upstream 100 bases:

>100_bases
AAAAAACTCCTTTAATGAAAAAAAATTTGCAAATTAAAGTTATTTTAGCGACTATAACAAGTGAAACCAAATAATAAAAT
TAAAAACCGACGGAGGTTAT

Downstream 100 bases:

>100_bases
AAATAAAAGGGTAAGTAATTACCCTCACTTTTATGTATTATAGATCAGTAAAATGATCAGAAAAGTGCGGTCAGAATTTA
TCAAATTTTCAATTTAGTTA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSAQNSLFSGSIVALVTPMNHYGEVDFSCLEKLVEHHIEAGSNALVSVGTTGESATLSIEENVKVIEKTVEFAKGRIPII
AGAGANATSEAITMTKLLRDSGVAGCLSVVPYYNKPTQEGIYQHFKAIAECTNLPQILYNVPSRTGSDMKPETVARLAEI
ENIVGIKEATGDVSRIVKIKQLAGKNFIVLSGDDATGLEAIKLGAEGVISVTNNIAAKDMADMYRYALVGDFDKAEEINA
RLMRLHHDLFIESNPIPVKWAAYRLGLIKSSHLRLPLTTLSEEIQPKVEDALKIAGLL

Sequences:

>Translated_298_residues
MSAQNSLFSGSIVALVTPMNHYGEVDFSCLEKLVEHHIEAGSNALVSVGTTGESATLSIEENVKVIEKTVEFAKGRIPII
AGAGANATSEAITMTKLLRDSGVAGCLSVVPYYNKPTQEGIYQHFKAIAECTNLPQILYNVPSRTGSDMKPETVARLAEI
ENIVGIKEATGDVSRIVKIKQLAGKNFIVLSGDDATGLEAIKLGAEGVISVTNNIAAKDMADMYRYALVGDFDKAEEINA
RLMRLHHDLFIESNPIPVKWAAYRLGLIKSSHLRLPLTTLSEEIQPKVEDALKIAGLL
>Mature_297_residues
SAQNSLFSGSIVALVTPMNHYGEVDFSCLEKLVEHHIEAGSNALVSVGTTGESATLSIEENVKVIEKTVEFAKGRIPIIA
GAGANATSEAITMTKLLRDSGVAGCLSVVPYYNKPTQEGIYQHFKAIAECTNLPQILYNVPSRTGSDMKPETVARLAEIE
NIVGIKEATGDVSRIVKIKQLAGKNFIVLSGDDATGLEAIKLGAEGVISVTNNIAAKDMADMYRYALVGDFDKAEEINAR
LMRLHHDLFIESNPIPVKWAAYRLGLIKSSHLRLPLTTLSEEIQPKVEDALKIAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=289, Percent_Identity=25.9515570934256, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI13540533, Length=295, Percent_Identity=26.4406779661017, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=58.2191780821918, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=29.7297297297297, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786463, Length=284, Percent_Identity=27.8169014084507, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789620, Length=282, Percent_Identity=24.468085106383, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32149; Mature: 32018

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQNSLFSGSIVALVTPMNHYGEVDFSCLEKLVEHHIEAGSNALVSVGTTGESATLSIE
CCCCCCCCCCCEEEEEECCHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEH
ENVKVIEKTVEFAKGRIPIIAGAGANATSEAITMTKLLRDSGVAGCLSVVPYYNKPTQEG
HHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHH
IYQHFKAIAECTNLPQILYNVPSRTGSDMKPETVARLAEIENIVGIKEATGDVSRIVKIK
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHCCCHHHHHHHHH
QLAGKNFIVLSGDDATGLEAIKLGAEGVISVTNNIAAKDMADMYRYALVGDFDKAEEINA
HHCCCCEEEEECCCCCCHHHHHCCCCCEEEHHCCHHHHHHHHHHHHHHHCCCCHHHHHHH
RLMRLHHDLFIESNPIPVKWAAYRLGLIKSSHLRLPLTTLSEEIQPKVEDALKIAGLL
HHHHHHHHHEECCCCCCEEHHHHHHHHEECCCCCCCHHHHHHHHCHHHHHHHHHHCCC
>Mature Secondary Structure 
SAQNSLFSGSIVALVTPMNHYGEVDFSCLEKLVEHHIEAGSNALVSVGTTGESATLSIE
CCCCCCCCCCEEEEEECCHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEH
ENVKVIEKTVEFAKGRIPIIAGAGANATSEAITMTKLLRDSGVAGCLSVVPYYNKPTQEG
HHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHH
IYQHFKAIAECTNLPQILYNVPSRTGSDMKPETVARLAEIENIVGIKEATGDVSRIVKIK
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHCCCHHHHHHHHH
QLAGKNFIVLSGDDATGLEAIKLGAEGVISVTNNIAAKDMADMYRYALVGDFDKAEEINA
HHCCCCEEEEECCCCCCHHHHHCCCCCEEEHHCCHHHHHHHHHHHHHHHCCCCHHHHHHH
RLMRLHHDLFIESNPIPVKWAAYRLGLIKSSHLRLPLTTLSEEIQPKVEDALKIAGLL
HHHHHHHHHEECCCCCCEEHHHHHHHHEECCCCCCCHHHHHHHHCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA