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The map label for this gene is metC [H]

Identifier: 148827265

GI number: 148827265

Start: 593540

End: 594727

Strand: Reverse

Name: metC [H]

Synonym: CGSHiGG_03195

Alternate gene names: 148827265

Gene position: 594727-593540 (Counterclockwise)

Preceding gene: 148827269

Following gene: 148827263

Centisome position: 31.51

GC content: 37.79

Gene sequence:

>1188_bases
ATGAAACAACACAATCTCTCAACAACATTTGTCCATGCAGGGCGTAAAAAACGTTTTTCACAAGGATCGGTAAACCCTAT
TTTACAGCGAGCTTCTTCATTACTATTTGACAGTATTGAAGATAAAAAACACGCTACTCGACGTAGAGCAAAAGGCGAAT
TATTTTATGGCAGAAGAGGGACGCTAACACATTTTGCTTTACAAGATTTAATGTGCGAAATGGAGGGGGGGGCAGGTTGT
TATCTTTATCCTTGTGGTACAGCAGCAGTAACTAATTCGATTCTTTCTTTTGTTAAAACTGGCGACCATGTGTTAATGAG
TGGCGCAGCTTACGAGCCAACCCAATATTTCTGTAATATTGTGCTGAAAAAAATGCAGATCGATATAACTTATTACGATC
CTCTTATTGGTGAAGATATTGCAACGCTTATTCAACCGAATACAAAAGTACTTTTCTTAGAAGCACCGAGTTCTATTACA
ATGGAAATTCCCGATATTCCGACTATTGTGAAGGTTGCAAGAAAGGTGAACCCTAATATTGTGATTATGATTGATAATAC
TTGGTCGGCTGGTGTTCTATTTAAAGCGTTAGAGCATGATATTGATATTTCTATTCAGGCGGGTACGAAATATTTAGTGG
GTCATTCAGATATTATGATTGGTACTGCCGTTGCGAATGCGCGAACTTGGGATCAACTTAGAGAACATTCCTATTTAATG
GGGCAAATGGTTGATGCAGATTCTGCTTATACGACTGCTCGTGGTATCCGTACATTGGGGGTACGATTAAAACAACATCA
GGAAAGCAGTATTAAAGTGGCAAAATGGTTGAGTGAGCAACCAGAAGTAAAAACTGTGTACCATCCAGCTTTACCAAGTT
GCCCTGGTCATGAATTCTTTTTACGTGATTTTAGTGGAAGCAGTGGTTTATTTTCTTTTGAACTAACCCAGCGATTAACT
TCAGAGCAAGTATCAAAATTTATGGATCATTTTCAACTGTTCGCTATGGCTTATTCATGGGGAGGATTTGAGTCTCTAAT
TCTTTGTAATCAACCAGAAGAAATTGCACATATTCGTCCAAATATTAAACGTAATCTTACAGGTTCATTAATTCGTGTGC
ATATTGGTTTTGAAAATGTGGATGAACTAATTGCAGATTTGAAAGCTGGTTTTGAGCGAATTGCTTAA

Upstream 100 bases:

>100_bases
GCCACACAAAATAGCGGCGCAATTCTATTTGAAACGCCGACATTTTATACTCGATTTTATCTATTAAAGCAATTAATCTT
ATCTAAAATAAGGTGGAAAT

Downstream 100 bases:

>100_bases
AAGTGCGGATAAAAAAATGCCTGTTTTACACAGGCATTTTTTATAGGATTATTTTTTTTCTGAAACTAAACCAATTTGGG
TACCGTCAGCAAAATGAATT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKQHNLSTTFVHAGRKKRFSQGSVNPILQRASSLLFDSIEDKKHATRRRAKGELFYGRRGTLTHFALQDLMCEMEGGAGC
YLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSIT
MEIPDIPTIVKVARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYLM
GQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRLT
SEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA

Sequences:

>Translated_395_residues
MKQHNLSTTFVHAGRKKRFSQGSVNPILQRASSLLFDSIEDKKHATRRRAKGELFYGRRGTLTHFALQDLMCEMEGGAGC
YLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSIT
MEIPDIPTIVKVARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYLM
GQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRLT
SEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
>Mature_395_residues
MKQHNLSTTFVHAGRKKRFSQGSVNPILQRASSLLFDSIEDKKHATRRRAKGELFYGRRGTLTHFALQDLMCEMEGGAGC
YLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSIT
MEIPDIPTIVKVARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYLM
GQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRLT
SEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=325, Percent_Identity=29.2307692307692, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI299473759, Length=242, Percent_Identity=30.9917355371901, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI25453487, Length=325, Percent_Identity=27.0769230769231, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1789383, Length=394, Percent_Identity=65.2284263959391, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1790375, Length=341, Percent_Identity=30.791788856305, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=332, Percent_Identity=32.2289156626506, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71980708, Length=349, Percent_Identity=31.5186246418338, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17538055, Length=385, Percent_Identity=29.0909090909091, Blast_Score=177, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6321170, Length=342, Percent_Identity=39.1812865497076, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319307, Length=399, Percent_Identity=26.8170426065163, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323333, Length=361, Percent_Identity=25.4847645429363, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=401, Percent_Identity=25.6857855361596, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321254, Length=307, Percent_Identity=25.7328990228013, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19922554, Length=342, Percent_Identity=30.7017543859649, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44227; Mature: 44227

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHNLSTTFVHAGRKKRFSQGSVNPILQRASSLLFDSIEDKKHATRRRAKGELFYGRRG
CCCCCCCHHEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
TLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNI
CHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
VLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKVARKVNPNI
HHHHHEEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCE
VIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYLM
EEEECCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCEEEEEHHCCCHHHHHHHHHHHHH
GQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFF
HHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEE
LRDFSGSSGLFSFELTQRLTSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRP
EEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCC
NIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQHNLSTTFVHAGRKKRFSQGSVNPILQRASSLLFDSIEDKKHATRRRAKGELFYGRRG
CCCCCCCHHEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
TLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNI
CHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
VLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKVARKVNPNI
HHHHHEEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCE
VIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYLM
EEEECCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCEEEEEHHCCCHHHHHHHHHHHHH
GQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFF
HHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEE
LRDFSGSSGLFSFELTQRLTSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRP
EEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCC
NIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]