Click here to switch to the map view.

The map label for this gene is serS [H]

Identifier: 148827255

GI number: 148827255

Start: 573421

End: 574710

Strand: Direct

Name: serS [H]

Synonym: CGSHiGG_03125

Alternate gene names: 148827255

Gene position: 573421-574710 (Clockwise)

Preceding gene: 148827253

Following gene: 148827256

Centisome position: 30.38

GC content: 40.31

Gene sequence:

>1290_bases
ATGATCGATCCAAATTTACTCCGTAATAATTTAGCAGAAGTCGCAGAAAAATTAAAAGTAAAACGCAACTTTATGCTTGA
TACGGAAAAACTCACTGCGTTAGAAGATCAGCGCAAAAACTTACAAGTCACTACCGAAAACTTACAAGCGGAACGTAATG
CTCGTTCCAAAGCCATTGGTGCTGCTAAAGCACGTGGTGAAGATATCGCACCATTATTGGCAGAAATGGATGATATGGGC
AATCAATTGACTGAAGCAAAAGCACAATTAGATGCGGTACTTGCAGAAATCAATCAAATTGCACTAAGTATTCCAAATCT
ACCCGCGGACGAAGTGCCATTAGGCAAAGATGACACAGAAAATAAAGAAATCTTACGTTGGGGAACACCGCGTACATTTG
ATTTTGAAGTCAAAGATCATGTCACTTTGGGTGAAGAAGCAAATGGCTTAGATTTTGCTGCTGGGGCTAAATTAACTGGT
GCGCGTTTTGCCGTAATGAAAGGTCAAATCGCTAAAATGCACCGCGCATTGGCACAATTCATGTTAGATCTTCATACGGA
ACAACACGGCTATTTAGAAACCTATGTGCCTTATTTAGTAAATCACGCCACACTTTATGGAACAGGGCAATTACCAAAAT
TCGGGGAAGATTTATTCCATACTTTAGCCTTACAAGGCGAACAACCTTACGCATTAATTCCAACCGCAGAAGTGCCAGTC
ACTAATTTAGTGCGTGATGTAATTATTGATGAAGCAGAATTACCAATAAAAATGACCGCACATACGCCATGTTTCCGTTC
TGAAGCAGGCTCTTACGGTCGTGATACTCGTGGTTTAATTCGTATGCACCAATTTGATAAAGTAGAAATGGTACAAATCG
TTGATCCAGATAAATCAATGGAAGCACTTGAAGAATTAACAGGTCATGCGGAAAAAGTATTGCAATTATTAAATTTACCA
TACCGTAAAGTTTTACTTTGCACAGGCGATATGGGCTTTGGTTCTTGCAAGACTTACGATTTAGAAGTCTGGGTGCCTGC
ACAAAATACTTATCGTGAAATTTCTTCTTGCTCAAATATGTGGGATTTCCAAGCTCGCCGTATGCAAGCACGTTGTAAAG
CAAAAGGGGATAAGAAAACCCACTTAGTGCATACCTTAAATGGTTCTGGCTTGGCTGTTGGTCGTACTTTAGTGGCTGTG
CTTGAAAACTATCAAAATGCCGATGGTTCAATCACCGTGCCAGAAGTGCTACGTCCATATATGGGCGGATTAGACGTTAT
CGGAAAATAA

Upstream 100 bases:

>100_bases
TTTCTTTATTTTTATACGTTGGCTTTTAAACTGGTTTATTTGAAGAAAGCACGCTAGAATAAGGTTGTTTTCATTTCAAC
GAAAAAAGTAAGGAAATTCT

Downstream 100 bases:

>100_bases
TCCTTCTATAAAATAAAAAAGCGTGGATTTTAAAATTTCCACGCTTTTTTATTATCAAAACCTTACAATAACTGTTTTAA
ATTTTTTGCTATTCAAGCCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIGAAKARGEDIAPLLAEMDDMG
NQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTENKEILRWGTPRTFDFEVKDHVTLGEEANGLDFAAGAKLTG
ARFAVMKGQIAKMHRALAQFMLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALQGEQPYALIPTAEVPV
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSMEALEELTGHAEKVLQLLNLP
YRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARCKAKGDKKTHLVHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEVLRPYMGGLDVIGK

Sequences:

>Translated_429_residues
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIGAAKARGEDIAPLLAEMDDMG
NQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTENKEILRWGTPRTFDFEVKDHVTLGEEANGLDFAAGAKLTG
ARFAVMKGQIAKMHRALAQFMLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALQGEQPYALIPTAEVPV
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSMEALEELTGHAEKVLQLLNLP
YRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARCKAKGDKKTHLVHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEVLRPYMGGLDVIGK
>Mature_429_residues
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIGAAKARGEDIAPLLAEMDDMG
NQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTENKEILRWGTPRTFDFEVKDHVTLGEEANGLDFAAGAKLTG
ARFAVMKGQIAKMHRALAQFMLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALQGEQPYALIPTAEVPV
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSMEALEELTGHAEKVLQLLNLP
YRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARCKAKGDKKTHLVHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEVLRPYMGGLDVIGK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=333, Percent_Identity=36.6366366366366, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=26.75, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI225579074, Length=324, Percent_Identity=29.0123456790123, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=77.4941995359629, Blast_Score=694, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=437, Percent_Identity=31.350114416476, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=328, Percent_Identity=31.0975609756098, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=396, Percent_Identity=32.5757575757576, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=390, Percent_Identity=28.974358974359, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24581334, Length=463, Percent_Identity=30.8855291576674, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI17737985, Length=339, Percent_Identity=29.7935103244838, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47688; Mature: 47688

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIG
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
AAKARGEDIAPLLAEMDDMGNQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NKEILRWGTPRTFDFEVKDHVTLGEEANGLDFAAGAKLTGARFAVMKGQIAKMHRALAQF
CCCEEECCCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALQGEQPYALIPTAEVPV
HHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCH
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSM
HHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHH
EALEELTGHAEKVLQLLNLPYRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNM
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHHHH
WDFQARRMQARCKAKGDKKTHLVHTLNGSGLAVGRTLVAVLENYQNADGSITVPEVLRPY
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLDVIGK
HCCCCCCCC
>Mature Secondary Structure
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIG
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
AAKARGEDIAPLLAEMDDMGNQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NKEILRWGTPRTFDFEVKDHVTLGEEANGLDFAAGAKLTGARFAVMKGQIAKMHRALAQF
CCCEEECCCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALQGEQPYALIPTAEVPV
HHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCH
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSM
HHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHH
EALEELTGHAEKVLQLLNLPYRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNM
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHHHH
WDFQARRMQARCKAKGDKKTHLVHTLNGSGLAVGRTLVAVLENYQNADGSITVPEVLRPY
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLDVIGK
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA