Click here to switch to the map view.

The map label for this gene is dld [H]

Identifier: 148827074

GI number: 148827074

Start: 341378

End: 343072

Strand: Reverse

Name: dld [H]

Synonym: CGSHiGG_01925

Alternate gene names: 148827074

Gene position: 343072-341378 (Counterclockwise)

Preceding gene: 148827076

Following gene: 148827071

Centisome position: 18.18

GC content: 39.29

Gene sequence:

>1695_bases
ATGTCTGTTCAACAACTCATTTCACGACTGACCGATATTGTTGGATCTCGTTATATTATTACTGATCCAACTAAAACAGA
AGCTTATCGAAGTGGTTATCGATTTGGAACAGGAAACGCCCTAGCTGTTGTTCGCCCTGCCACTCTACTTGAGTTTTGGA
ACATTGTAAAAGTTTGCGTTGAACATGATGTTATTGTTATAAACCAAGCGGCGAATACAGGTTTAACTGGTGGCTCTACA
CCAGATGGCAATGATTATGATCGCGATATTGTCGTCATCAATACAATGCGAATTGACGGAATCCAACTCATCAATAACGC
TTCCCAAGTTATTTGCTTACCAGGCTCTACACTCAATGAATTAGAAAATCAACTTAAACCGTTTGGTCGTGAACCCCACT
CTGTTATTGGCTCATCTTGCATTGGTGCATCAGTTATTGGTGGGATTTGTAACAACTCAGGTGGAGCATTAGTTCAACGT
GGACCAGCCTATACAGAAATGGCACTTTACGCTCAACTTAATGAAAAAGGTGAATTAGAACTAAAAAATCATTTAGGCAT
TGATTTAGGAGAAACTCCTGAAGAAATTTTAACTAATCTACAAGAAAAACGTTATCAGGTTAAAGATATTCGACAAGATT
GCGGACATGGTCACGACCATTACTACTGCAACTATGTTCGTCAAGTTGATGAAGACTCCCCTGCTCGTTTTAATGCCGAC
CCAGCTCGCCACTATGAAGCCTCAGGCTGTGCAGGAAAACTTGCTGTCTTTGCGGTTCGTTTAGACACCTTTCCGCTTGA
AAAAGAGACGGCTGTTTTCTATATCGGCACCAATCAAACTTCTGTGTTGAGCGATATTCGTCGCCACATGTTAGTAAACT
TCGAAGTGCTACCCATTTCAGGTGAATATATCCATCGTGATGCATTTGACATCGCAGCAAAATATGGCAAAGATATCTTT
TGGGTCATTAAAAAGTTTGGTACACATTGGCTACCAAAACTCTTTTCCTTAAAATCAAACGTGGATCGCATCGGCAAAAA
ATTCTTCTTTTTACCACAACATTTAAGCGATAAACTTATGCAAACTGTGTCTAAATTCATCCCAGAACATCTTCCACAAA
GCTTATGGGATTATCGCAACAAATACGAGCATCACTTAATTATCAAAATGGGTGGAAAAGGCATTCAAGAAGCCCGTGAA
TATTTGGAATCCTACATTGCAGATGGCTCAAAAGGTGGCTATTTTGAATGTAATGCAATCGAAACCCAAGCAGCAATGCT
TCATCGTTTCGCTGTTGCAAGTGCTGCAATTCGTTATCGTGCAATTCACGAAAAAGAAGTAGAAGAAATAGTTGCTTTAG
ATGTTGCATTACGTCGCAATGATCAAGATTGGTTTGAAGTGTTACCGCCAGAAATTGATAACAGAATTATCTCTAAACTT
TACTACGGGCATTTTATGTGCCATGTCTTTCACCAAGATTACATTGTAAAAAAAGGTTATGATTATGAAGAACTAGAATA
CGAAATGTTGAAATTACTTGACAAGCGTGGTGCGCAATACCCAGCCGAACACAATGTAGGGCATTTATACGAGGCTAAAC
CAACCTTGAGAAAATTCTATAAAGAGTTGGATCCAACCAATAGCTTTAATCCAGGTATTGGTAAAACGACGAGGAAAAAA
TACTGGGCGGAATAA

Upstream 100 bases:

>100_bases
GCAATTCCAAAAAACACCGATTAAAGCCTAAAATATCCTTATCCAAATGGGAATTATTCTGTTATAGTGCTATTAATTCT
TATTACAAGAGGATAATAAA

Downstream 100 bases:

>100_bases
ATCTCTAAAATGCAAACAAGATGTCAAATGTGACCGCTTGTTTATTATTTCCTCTTCTTAGATAGAGCCAACTCATCAAA
ATAAGGTCAGCAAATTATCT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCVEHDVIVINQAANTGLTGGST
PDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNELENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQR
GPAYTEMALYAQLNEKGELELKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEDSPARFNAD
PARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPISGEYIHRDAFDIAAKYGKDIF
WVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKLMQTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEARE
YLESYIADGSKGGYFECNAIETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKL
YYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFYKELDPTNSFNPGIGKTTRKK
YWAE

Sequences:

>Translated_564_residues
MSVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCVEHDVIVINQAANTGLTGGST
PDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNELENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQR
GPAYTEMALYAQLNEKGELELKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEDSPARFNAD
PARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPISGEYIHRDAFDIAAKYGKDIF
WVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKLMQTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEARE
YLESYIADGSKGGYFECNAIETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKL
YYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFYKELDPTNSFNPGIGKTTRKK
YWAE
>Mature_563_residues
SVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCVEHDVIVINQAANTGLTGGSTP
DGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNELENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQRG
PAYTEMALYAQLNEKGELELKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEDSPARFNADP
ARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPISGEYIHRDAFDIAAKYGKDIFW
VIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKLMQTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEAREY
LESYIADGSKGGYFECNAIETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKLY
YGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFYKELDPTNSFNPGIGKTTRKKY
WAE

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=561, Percent_Identity=59.7147950089127, Blast_Score=719, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 64163; Mature: 64031

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCV
CCHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
EHDVIVINQAANTGLTGGSTPDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNE
CCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHCCCCCEEEEECCCHHHH
LENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQRGPAYTEMALYAQLNEKGELE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCCEE
LKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEDSPARFNAD
EHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCC
PARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPIS
HHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEEEECC
GEYIHRDAFDIAAKYGKDIFWVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKLM
CCHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHH
QTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEAREYLESYIADGSKGGYFECNAI
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCH
ETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHH
YYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHH
KELDPTNSFNPGIGKTTRKKYWAE
HHCCCCCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure 
SVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCV
CHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
EHDVIVINQAANTGLTGGSTPDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNE
CCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHCCCCCEEEEECCCHHHH
LENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQRGPAYTEMALYAQLNEKGELE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCCEE
LKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEDSPARFNAD
EHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCC
PARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPIS
HHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEEEECC
GEYIHRDAFDIAAKYGKDIFWVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKLM
CCHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHH
QTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEAREYLESYIADGSKGGYFECNAI
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCH
ETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHH
YYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHH
KELDPTNSFNPGIGKTTRKKYWAE
HHCCCCCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]