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The map label for this gene is upp [H]

Identifier: 148827063

GI number: 148827063

Start: 331443

End: 332687

Strand: Direct

Name: upp [H]

Synonym: CGSHiGG_01870

Alternate gene names: 148827063

Gene position: 331443-332687 (Clockwise)

Preceding gene: 148827062

Following gene: 148827064

Centisome position: 17.56

GC content: 41.53

Gene sequence:

>1245_bases
ATGACAAACCAAATCCCTCCTTCCCTAGCGGAAAATCAAAGCAAATTAAAACAATCTTTCGTTGGCCTACAAATGCTTTT
TGTTGCATTTGGTGCACTAGTACTCGTGCCATTAATTACAGGCCTTGATTCCAATACGGCATTATTAACCGCTGGCGTTG
GCACCCTACTCTTCCAATTTTGCACAGGCAAACAAGTGCCTATTTTCTTGGCATCATCTTTTGCCTTTATCGCGCCCATT
CAATATGGCGTACAAACTTGGGGAATTGCGACTACGATGGGCGGTTTAGCGTTCACTGGTCTTGTTTATTTCGCCTTGAG
CACTTTAGTAAAATTACGGGGTGCAGAAGCATTACAACGTTTTTTCCCACCAGTGGTTGTTGGGCCAGTAATTATTATCA
TTGGCATGGGGCTTGCACCTATTGCGGTGGATATGTCCTTAGGCAAAAACAGTGCCTATGCTTATAACGACGCAATATTA
GTTTCAATGGTAACGCTTCTTACCACTTTATCTGTGGCAGTATTTGCCAAAGGATTGATGAAGCTTATTCCAATAATGTT
CGGTATTACCGCAGGCTATATTTTGTGTTTATTTCTAGGTTTAATTAATTTCCAACCAGTGATTGATGCGCCTTGGTTCA
GTTTGCCCAAATTAACGACACCTGAATTTAACCTAGAAGCTATTCTTTATATGTTACCAATTGCTATTGCCCCCGCCGTA
GAACACGTTGGCGGTATTATGGCAATCAGCTCTGTAACAAGTAAAGACTTTTTAAAAAAACCAGGATTACACCGCACTTT
ATTAGGCGATGGCGTCGCTACCGCTGCTGCCTCTTTAGTTGGTGGCCCGCCTAATACGACTTATGCGGAAGTTACTGGTG
CTGTGATGCTAACACGCAACTTTAACCCAAATATTATGACTTGGGCTGCAGTTTGGGCTATTGCGATTTCATTCTGTGGA
AAAGTAGGCGCATTCCTATCAACCATTCCAACGATTGTAATGGGTGGAATTATGATGCTTGTTTTCGGTTCAATCGCAGT
TGTGGGCATGAGTACCTTAATTCGCGGAAAAGTTGATGTTACCGAAGCTCGTAATCTTTGTATTATTTCTGTCGTCATGA
CATTTGGTATCGGCAATATGTTTGTAGATGTGGGTAACGTATCACTAAAAGGTATCAGCTTGTGTGCGATTGTTGCTATC
ATCTTAAACCTTGTTTTACCGAAAGCAAAAAATGAAGTAGAATAA

Upstream 100 bases:

>100_bases
CCAAAACAAGACGGCATTTAAGCCGTCTTTTTTCCGTGCGTGAAACACAAGAAAAACTGACCGCACTTTTAAGTTAATTC
AAACAGAGAGTTGAAACTAA

Downstream 100 bases:

>100_bases
GCCTCATTTCAGGGTTAAATTATCATTTAGCCCTTTCTTACTTAATCTGTACTACATAAACATTTGAATAAGCAACTCCC
CTTACCTATTCATCAAATTG

Product: uracil phosphoribosyltransferase

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTNQIPPSLAENQSKLKQSFVGLQMLFVAFGALVLVPLITGLDSNTALLTAGVGTLLFQFCTGKQVPIFLASSFAFIAPI
QYGVQTWGIATTMGGLAFTGLVYFALSTLVKLRGAEALQRFFPPVVVGPVIIIIGMGLAPIAVDMSLGKNSAYAYNDAIL
VSMVTLLTTLSVAVFAKGLMKLIPIMFGITAGYILCLFLGLINFQPVIDAPWFSLPKLTTPEFNLEAILYMLPIAIAPAV
EHVGGIMAISSVTSKDFLKKPGLHRTLLGDGVATAAASLVGGPPNTTYAEVTGAVMLTRNFNPNIMTWAAVWAIAISFCG
KVGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVTEARNLCIISVVMTFGIGNMFVDVGNVSLKGISLCAIVAI
ILNLVLPKAKNEVE

Sequences:

>Translated_414_residues
MTNQIPPSLAENQSKLKQSFVGLQMLFVAFGALVLVPLITGLDSNTALLTAGVGTLLFQFCTGKQVPIFLASSFAFIAPI
QYGVQTWGIATTMGGLAFTGLVYFALSTLVKLRGAEALQRFFPPVVVGPVIIIIGMGLAPIAVDMSLGKNSAYAYNDAIL
VSMVTLLTTLSVAVFAKGLMKLIPIMFGITAGYILCLFLGLINFQPVIDAPWFSLPKLTTPEFNLEAILYMLPIAIAPAV
EHVGGIMAISSVTSKDFLKKPGLHRTLLGDGVATAAASLVGGPPNTTYAEVTGAVMLTRNFNPNIMTWAAVWAIAISFCG
KVGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVTEARNLCIISVVMTFGIGNMFVDVGNVSLKGISLCAIVAI
ILNLVLPKAKNEVE
>Mature_413_residues
TNQIPPSLAENQSKLKQSFVGLQMLFVAFGALVLVPLITGLDSNTALLTAGVGTLLFQFCTGKQVPIFLASSFAFIAPIQ
YGVQTWGIATTMGGLAFTGLVYFALSTLVKLRGAEALQRFFPPVVVGPVIIIIGMGLAPIAVDMSLGKNSAYAYNDAILV
SMVTLLTTLSVAVFAKGLMKLIPIMFGITAGYILCLFLGLINFQPVIDAPWFSLPKLTTPEFNLEAILYMLPIAIAPAVE
HVGGIMAISSVTSKDFLKKPGLHRTLLGDGVATAAASLVGGPPNTTYAEVTGAVMLTRNFNPNIMTWAAVWAIAISFCGK
VGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVTEARNLCIISVVMTFGIGNMFVDVGNVSLKGISLCAIVAII
LNLVLPKAKNEVE

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=433, Percent_Identity=21.9399538106236, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI40316845, Length=433, Percent_Identity=21.9399538106236, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI44680143, Length=432, Percent_Identity=23.3796296296296, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI44680145, Length=429, Percent_Identity=22.8438228438228, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788843, Length=399, Percent_Identity=36.8421052631579, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI87081818, Length=413, Percent_Identity=34.6246973365617, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87082181, Length=408, Percent_Identity=24.2647058823529, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082178, Length=323, Percent_Identity=23.8390092879257, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=417, Percent_Identity=23.9808153477218, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=410, Percent_Identity=21.9512195121951, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356175, Length=421, Percent_Identity=23.0403800475059, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 43603; Mature: 43472

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQIPPSLAENQSKLKQSFVGLQMLFVAFGALVLVPLITGLDSNTALLTAGVGTLLFQF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
CTGKQVPIFLASSFAFIAPIQYGVQTWGIATTMGGLAFTGLVYFALSTLVKLRGAEALQR
HCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
FFPPVVVGPVIIIIGMGLAPIAVDMSLGKNSAYAYNDAILVSMVTLLTTLSVAVFAKGLM
HCCHHHHHHHHHHHHCCHHHHEEEHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
KLIPIMFGITAGYILCLFLGLINFQPVIDAPWFSLPKLTTPEFNLEAILYMLPIAIAPAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EHVGGIMAISSVTSKDFLKKPGLHRTLLGDGVATAAASLVGGPPNTTYAEVTGAVMLTRN
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHCCCCCCCCHHHHHCEEEEEEC
FNPNIMTWAAVWAIAISFCGKVGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TEARNLCIISVVMTFGIGNMFVDVGNVSLKGISLCAIVAIILNLVLPKAKNEVE
HHHCCHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TNQIPPSLAENQSKLKQSFVGLQMLFVAFGALVLVPLITGLDSNTALLTAGVGTLLFQF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
CTGKQVPIFLASSFAFIAPIQYGVQTWGIATTMGGLAFTGLVYFALSTLVKLRGAEALQR
HCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
FFPPVVVGPVIIIIGMGLAPIAVDMSLGKNSAYAYNDAILVSMVTLLTTLSVAVFAKGLM
HCCHHHHHHHHHHHHCCHHHHEEEHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
KLIPIMFGITAGYILCLFLGLINFQPVIDAPWFSLPKLTTPEFNLEAILYMLPIAIAPAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EHVGGIMAISSVTSKDFLKKPGLHRTLLGDGVATAAASLVGGPPNTTYAEVTGAVMLTRN
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHCCCCCCCCHHHHHCEEEEEEC
FNPNIMTWAAVWAIAISFCGKVGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TEARNLCIISVVMTFGIGNMFVDVGNVSLKGISLCAIVAIILNLVLPKAKNEVE
HHHCCHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]