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The map label for this gene is tmcA [H]

Identifier: 148827039

GI number: 148827039

Start: 296507

End: 298351

Strand: Reverse

Name: tmcA [H]

Synonym: CGSHiGG_01730

Alternate gene names: 148827039

Gene position: 298351-296507 (Counterclockwise)

Preceding gene: 148827040

Following gene: 148827038

Centisome position: 15.81

GC content: 38.92

Gene sequence:

>1845_bases
ATGTCATCTCGCCAGCTTCAAATTTTAATCAGAAAAACTTTGCCGCTTGTGCCTGATAACGTATTAATTATCGGCGAAAG
TGGCATTGCTTTTTCTAAAGCAACGAATTTGCTCGGGCAAGAATTTGAACATATTTTATTTGATGCGCGAAATGGCATTC
ATCTTGAAGCACTGGCTATTGCAGCTGGAACACTGAAAATGGGCGGCACACTTTGTTTAGTGTTATCTGATTGGGAAAAT
TTATCTCAGCAGCCTGATCAAGATAGTTTACGTTGGAATGGAAATCAGTCAGCTATCGCCACGCCTAATTTTATTTATCA
TTTCAAACAGTACATTGAACGTTATCACTTCCCCATTTTAAGAGAGGAAAGTGCGGTTGAATTTCCTACGGTTTTTTATT
CTAACGAACATCACAAAAATGCCACGTTAGCGCAACAACAAATTATCGAGACTATTTTACAAGCCGAGCAGGATATTTAT
TTTCTAACCGCCAAGCGAGGAAGAGGAAAATCCGCATTATTGGGTATGCTTGCTAACCAAATTCAAGCACCAGTTTATCT
TACCGCACCGAATAAAAGTGCGGTGCATTCCGTTATTGAATTTTCAGAACGAGAGATAGAATTTATCGCGCCAGATGAAT
TGGCTTTGACGTTACAAACTGAACCCGAATTTAGTCAATCTGCTTGGTTGCTGGTAGATGAAGCGGCGATGATCCCATTG
CCGTTATTGCAAGAATGTTCTCAATATTTTCAACATATTGTCTTTAGTACTACAATTCATAGCTACGAAGGTACGGGGCG
TGGTTTCGAATTAAAATTTAAACGGAAAATTCACCGCACTTTTCAGCATTTTGAGCTTAAACAGCCCCTACGTTGGCAAG
AAAATGACCCGTTAGAACATTTTATTGATGATCTTTTATTGCTAAATGCCGAAGATGATTTTCAGCAATTTCCTTTTCAG
CCTCATCTCCCTTATCAAATTCGAGAAGTGCAAAAAACACAGCATATTGTAGAGTTTTATGGCTTAATGACATTGGCACA
TTATCGAACATCGCCACTCGATCTTCGTCGTTTACTGGATGGGAAAAATCAACGTTTTTATTTTGCCGAATATCAACAGA
ATTTGCTCGGTGCAATTTGGGCATTAGAAGAAGGAAATATGGCTGATGATGAGTTGATTATTCAAATTCAACAAGGCAAA
CGTCGCCCGAAAGGGAATCTTGTGCCACAAGCCTTGTGTTTCCACGAAAATCTTTCCCAAGCCTGTAAACTGCGTTCACT
CCGCATTTCACGTATCGCCGTGCAACCAAATTGGCAGCAAAAGGGCATTGGGCAAAATTTGATGCAAGCCATGGAAAATG
CCGATGTGGATTTTCTTTCGGTGAGTTTTGGTTACACTGATGAACTCGCAAAATTTTGGCAAAAGTGCGGTTTTGTTTTG
GTGCATTTAGGCGAGCATCAAGAAGCGAGTAGTGGTTGTTATTCAGCGATTGCCCTTAAAGGTATTTCCAAAGAAGGCTT
GGCTTTAGTTGATACTGCGTACAAACAATTTCAGCGTAATCTCCCTTTATCTTTTCATCCGTTTGCCATAAATTTTGAGC
AAAATCAGCTTGATTGGCAGCTTGATGAATTCGATTGGATGAGCTTAAAAAACTTCGCTAATTTTCACCGCACTTTATTT
TCGAGCATTCCTGCAATAAGGCGTTTATTAAAATTAGCGGGCAAAGAAAATTTCCCATTAATTTCCGCTTATTTAACAAA
AAAACAATTTCCTATTAACAAGAAAAAAGGCGTAGAATGTTTGCGTTTAGAAATTAAACAATATTTAGAGCGAGGAACTT
TATGA

Upstream 100 bases:

>100_bases
TTTTTCAGTAAAAAAGTTTCTCAACCCAAAAGCATTTTCTTTTGGCTTGCTTGCGTAAGTTTTATTGGTGCGATGTTAAT
TGCCTATTTGAAATAAAACG

Downstream 100 bases:

>100_bases
CAGAACAAACCGCAAAACCAAAAGGCTGGTTTAAACGCGCACTTGAAAAATATGACAACTTCATTAAAGAATGGGGTTTA
GATCAACCGAATTGTAGCTG

Product: P-loop ATPase fused to an acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 613

Protein sequence:

>614_residues
MSSRQLQILIRKTLPLVPDNVLIIGESGIAFSKATNLLGQEFEHILFDARNGIHLEALAIAAGTLKMGGTLCLVLSDWEN
LSQQPDQDSLRWNGNQSAIATPNFIYHFKQYIERYHFPILREESAVEFPTVFYSNEHHKNATLAQQQIIETILQAEQDIY
FLTAKRGRGKSALLGMLANQIQAPVYLTAPNKSAVHSVIEFSEREIEFIAPDELALTLQTEPEFSQSAWLLVDEAAMIPL
PLLQECSQYFQHIVFSTTIHSYEGTGRGFELKFKRKIHRTFQHFELKQPLRWQENDPLEHFIDDLLLLNAEDDFQQFPFQ
PHLPYQIREVQKTQHIVEFYGLMTLAHYRTSPLDLRRLLDGKNQRFYFAEYQQNLLGAIWALEEGNMADDELIIQIQQGK
RRPKGNLVPQALCFHENLSQACKLRSLRISRIAVQPNWQQKGIGQNLMQAMENADVDFLSVSFGYTDELAKFWQKCGFVL
VHLGEHQEASSGCYSAIALKGISKEGLALVDTAYKQFQRNLPLSFHPFAINFEQNQLDWQLDEFDWMSLKNFANFHRTLF
SSIPAIRRLLKLAGKENFPLISAYLTKKQFPINKKKGVECLRLEIKQYLERGTL

Sequences:

>Translated_614_residues
MSSRQLQILIRKTLPLVPDNVLIIGESGIAFSKATNLLGQEFEHILFDARNGIHLEALAIAAGTLKMGGTLCLVLSDWEN
LSQQPDQDSLRWNGNQSAIATPNFIYHFKQYIERYHFPILREESAVEFPTVFYSNEHHKNATLAQQQIIETILQAEQDIY
FLTAKRGRGKSALLGMLANQIQAPVYLTAPNKSAVHSVIEFSEREIEFIAPDELALTLQTEPEFSQSAWLLVDEAAMIPL
PLLQECSQYFQHIVFSTTIHSYEGTGRGFELKFKRKIHRTFQHFELKQPLRWQENDPLEHFIDDLLLLNAEDDFQQFPFQ
PHLPYQIREVQKTQHIVEFYGLMTLAHYRTSPLDLRRLLDGKNQRFYFAEYQQNLLGAIWALEEGNMADDELIIQIQQGK
RRPKGNLVPQALCFHENLSQACKLRSLRISRIAVQPNWQQKGIGQNLMQAMENADVDFLSVSFGYTDELAKFWQKCGFVL
VHLGEHQEASSGCYSAIALKGISKEGLALVDTAYKQFQRNLPLSFHPFAINFEQNQLDWQLDEFDWMSLKNFANFHRTLF
SSIPAIRRLLKLAGKENFPLISAYLTKKQFPINKKKGVECLRLEIKQYLERGTL
>Mature_613_residues
SSRQLQILIRKTLPLVPDNVLIIGESGIAFSKATNLLGQEFEHILFDARNGIHLEALAIAAGTLKMGGTLCLVLSDWENL
SQQPDQDSLRWNGNQSAIATPNFIYHFKQYIERYHFPILREESAVEFPTVFYSNEHHKNATLAQQQIIETILQAEQDIYF
LTAKRGRGKSALLGMLANQIQAPVYLTAPNKSAVHSVIEFSEREIEFIAPDELALTLQTEPEFSQSAWLLVDEAAMIPLP
LLQECSQYFQHIVFSTTIHSYEGTGRGFELKFKRKIHRTFQHFELKQPLRWQENDPLEHFIDDLLLLNAEDDFQQFPFQP
HLPYQIREVQKTQHIVEFYGLMTLAHYRTSPLDLRRLLDGKNQRFYFAEYQQNLLGAIWALEEGNMADDELIIQIQQGKR
RPKGNLVPQALCFHENLSQACKLRSLRISRIAVQPNWQQKGIGQNLMQAMENADVDFLSVSFGYTDELAKFWQKCGFVLV
HLGEHQEASSGCYSAIALKGISKEGLALVDTAYKQFQRNLPLSFHPFAINFEQNQLDWQLDEFDWMSLKNFANFHRTLFS
SIPAIRRLLKLAGKENFPLISAYLTKKQFPINKKKGVECLRLEIKQYLERGTL

Specific function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) [H]

COG id: COG1444

COG function: function code R; Predicted P-loop ATPase fused to an acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI221316741, Length=371, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI221316723, Length=371, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1788818, Length=563, Percent_Identity=39.0763765541741, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17507621, Length=364, Percent_Identity=24.7252747252747, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640662, Length=356, Percent_Identity=25.561797752809, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013562
- InterPro:   IPR007807 [H]

Pfam domain/function: PF08351 DUF1726; PF05127 DUF699 [H]

EC number: NA

Molecular weight: Translated: 70723; Mature: 70592

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRQLQILIRKTLPLVPDNVLIIGESGIAFSKATNLLGQEFEHILFDARNGIHLEALAI
CCCCHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
AAGTLKMGGTLCLVLSDWENLSQQPDQDSLRWNGNQSAIATPNFIYHFKQYIERYHFPIL
HHHHEECCCEEEEEEECHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
REESAVEFPTVFYSNEHHKNATLAQQQIIETILQAEQDIYFLTAKRGRGKSALLGMLANQ
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
IQAPVYLTAPNKSAVHSVIEFSEREIEFIAPDELALTLQTEPEFSQSAWLLVDEAAMIPL
HCCCEEEECCCHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCCC
PLLQECSQYFQHIVFSTTIHSYEGTGRGFELKFKRKIHRTFQHFELKQPLRWQENDPLEH
HHHHHHHHHHHHHHHHHHEECCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
FIDDLLLLNAEDDFQQFPFQPHLPYQIREVQKTQHIVEFYGLMTLAHYRTSPLDLRRLLD
HHHHHEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
GKNQRFYFAEYQQNLLGAIWALEEGNMADDELIIQIQQGKRRPKGNLVPQALCFHENLSQ
CCCCEEEEHHHHHHHHHHHHEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ACKLRSLRISRIAVQPNWQQKGIGQNLMQAMENADVDFLSVSFGYTDELAKFWQKCGFVL
HHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEE
VHLGEHQEASSGCYSAIALKGISKEGLALVDTAYKQFQRNLPLSFHPFAINFEQNQLDWQ
EEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEECCEEEEECCCCCCCE
LDEFDWMSLKNFANFHRTLFSSIPAIRRLLKLAGKENFPLISAYLTKKQFPINKKKGVEC
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCHHH
LRLEIKQYLERGTL
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SSRQLQILIRKTLPLVPDNVLIIGESGIAFSKATNLLGQEFEHILFDARNGIHLEALAI
CCCHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
AAGTLKMGGTLCLVLSDWENLSQQPDQDSLRWNGNQSAIATPNFIYHFKQYIERYHFPIL
HHHHEECCCEEEEEEECHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
REESAVEFPTVFYSNEHHKNATLAQQQIIETILQAEQDIYFLTAKRGRGKSALLGMLANQ
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
IQAPVYLTAPNKSAVHSVIEFSEREIEFIAPDELALTLQTEPEFSQSAWLLVDEAAMIPL
HCCCEEEECCCHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCCC
PLLQECSQYFQHIVFSTTIHSYEGTGRGFELKFKRKIHRTFQHFELKQPLRWQENDPLEH
HHHHHHHHHHHHHHHHHHEECCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
FIDDLLLLNAEDDFQQFPFQPHLPYQIREVQKTQHIVEFYGLMTLAHYRTSPLDLRRLLD
HHHHHEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
GKNQRFYFAEYQQNLLGAIWALEEGNMADDELIIQIQQGKRRPKGNLVPQALCFHENLSQ
CCCCEEEEHHHHHHHHHHHHEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ACKLRSLRISRIAVQPNWQQKGIGQNLMQAMENADVDFLSVSFGYTDELAKFWQKCGFVL
HHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEE
VHLGEHQEASSGCYSAIALKGISKEGLALVDTAYKQFQRNLPLSFHPFAINFEQNQLDWQ
EEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEECCEEEEECCCCCCCE
LDEFDWMSLKNFANFHRTLFSSIPAIRRLLKLAGKENFPLISAYLTKKQFPINKKKGVEC
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCHHH
LRLEIKQYLERGTL
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]