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The map label for this gene is fhuB [H]

Identifier: 148826684

GI number: 148826684

Start: 1738230

End: 1740200

Strand: Direct

Name: fhuB [H]

Synonym: CGSHiEE_08785

Alternate gene names: 148826684

Gene position: 1738230-1740200 (Clockwise)

Preceding gene: 148826683

Following gene: 148826685

Centisome position: 95.87

GC content: 54.49

Gene sequence:

>1971_bases
ATGGTAAACCGCGCCGCATTATTGATTGTCGTGTTGAGCGTGATTTTCGTCGCGCTCGGCGCATTCTTACTGCACCTGCA
ACTGCCGCCCGACACGGTACTGACCGATTTATTGCGCGCCAGCGATTCGCTGCCGTTATTGTTGGTGCAAAGCTACACTC
TGCCGCGCATTAGCATCGCGTTACTCGCCGGCGGCGGGCTGGCGTTCGCCGCATTATTGTTGCAACAAGTGATGAGCAAT
CCGCTCGCCTCCGACAACACCCTCGGTATCAGCGGCGGCGCGCAGTTCGGGCTGTTTTTAAGCGCTATTTTCGCGCCGCA
GTTATTGGAATACGGCAGCGGCTTAATCGCGTTGCTCGGCACGAGCTTGAGTTTATTGTTGGTGATGAGCTTGTCGCTGC
GCAAAACCATGTCGCCGTTATTGTTAATTTTGGCGGGCTTGGTGGTTAATTTATATTTCGGCGCGTTCACCGGAATGATG
ATGTTATTTTATCCGGAAGAATCGCGCGGCTTGGCTCAATGGGGCGCTGGCTCGTTGGTGCAGGAAAGCTGGCGCGACAG
CCAGTGGCTGCTGGCGCAAAGTGCGGTCGGTTTTTGCCTTGTTTTTTCATTTATCCGCCCGCTCACCATTCTGACCTTGA
ACGACAGCAACGCACAGAGCCTCGGCGTGCCGGTGGGCAAATTGCGCCTGTTTGCGGTGATCGTCAGCGCGTATTTAATC
GCCGCCGTGGTCAGCGCGGTGAGTATGCTCGGTTTCATCGGCTTGGCGGCGGCAACCATTGTGCGCCAGCTCGGCGTGCG
AACTTTAGCGTGGCAGTTAATTTCGGCATTTTTGGTGGGTGCGTTGTTATTGGCGATCACCGATTTATTGCTACAACTAC
TTAATTTTTATACGCAACTCAGTTTCCCGACCGGTGCAGTCACCGCCTTATTGGGCACGCCGTTATTGCTGTGGCTGATG
TTCCGCGCGTTGCCGCACAGCGGACGGCTAACCGGCGAGGAACGGAAAAAACAACGCCGATTTCGACCGCACTTTACTTG
GCTGCTGATTATTCTGTTCGCCGTCAGTTTGTGGCTGGCGCTGAATGTAGGCAAAAGCGCGTTCGATCAGTGGTCGGTGC
TGGATTTCAATCACCCGTTTGCGCCGGAAATCCTCAATCTGCGCTATCCGCGCATTTTAATCGCGCTGTGCGCCGGCATT
TTGCTGTCCGTTGCCGGCGTGTTATTGCAGCGCCTGACCTTAAACCCAATGGCAAGCCCAGAATTATTGGGCGTGTCTTC
TGGAGCGAGTATGGGGATTTTGCTGCTATTGTTCGTGTTTTCCGCCCAGCAGCCGCTATGGTTCTGGCTGGCGGGCATCG
GCGGTGCACTGGTCGCCCTGTTGATTTTATCCGCGATTAATCGCCACAACGGTATGTTGCCGGAAAAAGTGTTGCTGACC
GGTATCAGTTTGTCCGCACTGTTCAACACCTTACAACGGATTGCGATTGCCAGCGGCGATCCGCGTGCCAATCAACTGAT
CGCGTGGACTTCTGGCTCGACGCAAAACACCACGCCGGAACTTGCCGTGCCGTTTATGGGGCTGAGCCTTGTTCTGCTGG
CGGGCAGTTTATTGTTCAGCCGTTGGCTGGAATTGTTGAGCCTGCAAGCGCCAATGGCGCAGGCTTTAGGCTTGAACTTA
AAACGCGCGCGCCTGCTGCTGATTTTATTCAGCGCCGTGCTGACCGCACTTGCCACTCTGATGATCGGTCCGTTAAGTTT
TATCGGGTTGTTAGTGCCGCATCTGACTTATTCCTTAGGCGTGCACAAAGCCAAGGCGCAACTGCTGATTTCCGCTTTGT
TAGGCGGCACGATTATGTTGCTGGCGGATTGGTTCGGGCGGCAAATTTTGTTTCCGTACGAAATTCCGGCTGGCTTGGTC
GCCACCCTACTCGGCGGCACTTATTTCTTGTTCATACTGCGGAAAATTTAA

Upstream 100 bases:

>100_bases
AAGCATTGATTCTACCGGCGGTGTGGTCGTTCGGTGCGATTCCGTCGGCACGGCGTTTCGCCCATGTGTTCGCCGATGGC
TTACTGCACGGAGGTGACGC

Downstream 100 bases:

>100_bases
TCCGCCGCAGGAATTTTTATGGTAAACCCGTTCTGCGCCAAACGCACAACGCGGCTTGCCGAAAATGTAAATGTAGTTTG
ACGACTACGCAATTTAACTT

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MVNRAALLIVVLSVIFVALGAFLLHLQLPPDTVLTDLLRASDSLPLLLVQSYTLPRISIALLAGGGLAFAALLLQQVMSN
PLASDNTLGISGGAQFGLFLSAIFAPQLLEYGSGLIALLGTSLSLLLVMSLSLRKTMSPLLLILAGLVVNLYFGAFTGMM
MLFYPEESRGLAQWGAGSLVQESWRDSQWLLAQSAVGFCLVFSFIRPLTILTLNDSNAQSLGVPVGKLRLFAVIVSAYLI
AAVVSAVSMLGFIGLAAATIVRQLGVRTLAWQLISAFLVGALLLAITDLLLQLLNFYTQLSFPTGAVTALLGTPLLLWLM
FRALPHSGRLTGEERKKQRRFRPHFTWLLIILFAVSLWLALNVGKSAFDQWSVLDFNHPFAPEILNLRYPRILIALCAGI
LLSVAGVLLQRLTLNPMASPELLGVSSGASMGILLLLFVFSAQQPLWFWLAGIGGALVALLILSAINRHNGMLPEKVLLT
GISLSALFNTLQRIAIASGDPRANQLIAWTSGSTQNTTPELAVPFMGLSLVLLAGSLLFSRWLELLSLQAPMAQALGLNL
KRARLLLILFSAVLTALATLMIGPLSFIGLLVPHLTYSLGVHKAKAQLLISALLGGTIMLLADWFGRQILFPYEIPAGLV
ATLLGGTYFLFILRKI

Sequences:

>Translated_656_residues
MVNRAALLIVVLSVIFVALGAFLLHLQLPPDTVLTDLLRASDSLPLLLVQSYTLPRISIALLAGGGLAFAALLLQQVMSN
PLASDNTLGISGGAQFGLFLSAIFAPQLLEYGSGLIALLGTSLSLLLVMSLSLRKTMSPLLLILAGLVVNLYFGAFTGMM
MLFYPEESRGLAQWGAGSLVQESWRDSQWLLAQSAVGFCLVFSFIRPLTILTLNDSNAQSLGVPVGKLRLFAVIVSAYLI
AAVVSAVSMLGFIGLAAATIVRQLGVRTLAWQLISAFLVGALLLAITDLLLQLLNFYTQLSFPTGAVTALLGTPLLLWLM
FRALPHSGRLTGEERKKQRRFRPHFTWLLIILFAVSLWLALNVGKSAFDQWSVLDFNHPFAPEILNLRYPRILIALCAGI
LLSVAGVLLQRLTLNPMASPELLGVSSGASMGILLLLFVFSAQQPLWFWLAGIGGALVALLILSAINRHNGMLPEKVLLT
GISLSALFNTLQRIAIASGDPRANQLIAWTSGSTQNTTPELAVPFMGLSLVLLAGSLLFSRWLELLSLQAPMAQALGLNL
KRARLLLILFSAVLTALATLMIGPLSFIGLLVPHLTYSLGVHKAKAQLLISALLGGTIMLLADWFGRQILFPYEIPAGLV
ATLLGGTYFLFILRKI
>Mature_656_residues
MVNRAALLIVVLSVIFVALGAFLLHLQLPPDTVLTDLLRASDSLPLLLVQSYTLPRISIALLAGGGLAFAALLLQQVMSN
PLASDNTLGISGGAQFGLFLSAIFAPQLLEYGSGLIALLGTSLSLLLVMSLSLRKTMSPLLLILAGLVVNLYFGAFTGMM
MLFYPEESRGLAQWGAGSLVQESWRDSQWLLAQSAVGFCLVFSFIRPLTILTLNDSNAQSLGVPVGKLRLFAVIVSAYLI
AAVVSAVSMLGFIGLAAATIVRQLGVRTLAWQLISAFLVGALLLAITDLLLQLLNFYTQLSFPTGAVTALLGTPLLLWLM
FRALPHSGRLTGEERKKQRRFRPHFTWLLIILFAVSLWLALNVGKSAFDQWSVLDFNHPFAPEILNLRYPRILIALCAGI
LLSVAGVLLQRLTLNPMASPELLGVSSGASMGILLLLFVFSAQQPLWFWLAGIGGALVALLILSAINRHNGMLPEKVLLT
GISLSALFNTLQRIAIASGDPRANQLIAWTSGSTQNTTPELAVPFMGLSLVLLAGSLLFSRWLELLSLQAPMAQALGLNL
KRARLLLILFSAVLTALATLMIGPLSFIGLLVPHLTYSLGVHKAKAQLLISALLGGTIMLLADWFGRQILFPYEIPAGLV
ATLLGGTYFLFILRKI

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=620, Percent_Identity=39.3548387096774, Blast_Score=321, Evalue=1e-88,
Organism=Escherichia coli, GI1790741, Length=318, Percent_Identity=36.1635220125786, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790740, Length=283, Percent_Identity=32.1554770318021, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI1786805, Length=284, Percent_Identity=36.2676056338028, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786804, Length=282, Percent_Identity=31.5602836879433, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788004, Length=279, Percent_Identity=30.1075268817204, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70590; Mature: 70590

Theoretical pI: Translated: 10.53; Mature: 10.53

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNRAALLIVVLSVIFVALGAFLLHLQLPPDTVLTDLLRASDSLPLLLVQSYTLPRISIA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHH
LLAGGGLAFAALLLQQVMSNPLASDNTLGISGGAQFGLFLSAIFAPQLLEYGSGLIALLG
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
TSLSLLLVMSLSLRKTMSPLLLILAGLVVNLYFGAFTGMMMLFYPEESRGLAQWGAGSLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHCCCCHHH
QESWRDSQWLLAQSAVGFCLVFSFIRPLTILTLNDSNAQSLGVPVGKLRLFAVIVSAYLI
HHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHHHH
AAVVSAVSMLGFIGLAAATIVRQLGVRTLAWQLISAFLVGALLLAITDLLLQLLNFYTQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SFPTGAVTALLGTPLLLWLMFRALPHSGRLTGEERKKQRRFRPHFTWLLIILFAVSLWLA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LNVGKSAFDQWSVLDFNHPFAPEILNLRYPRILIALCAGILLSVAGVLLQRLTLNPMASP
HHCCHHHHCCCCEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ELLGVSSGASMGILLLLFVFSAQQPLWFWLAGIGGALVALLILSAINRHNGMLPEKVLLT
CCEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
GISLSALFNTLQRIAIASGDPRANQLIAWTSGSTQNTTPELAVPFMGLSLVLLAGSLLFS
CCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RWLELLSLQAPMAQALGLNLKRARLLLILFSAVLTALATLMIGPLSFIGLLVPHLTYSLG
HHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VHKAKAQLLISALLGGTIMLLADWFGRQILFPYEIPAGLVATLLGGTYFLFILRKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MVNRAALLIVVLSVIFVALGAFLLHLQLPPDTVLTDLLRASDSLPLLLVQSYTLPRISIA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHH
LLAGGGLAFAALLLQQVMSNPLASDNTLGISGGAQFGLFLSAIFAPQLLEYGSGLIALLG
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
TSLSLLLVMSLSLRKTMSPLLLILAGLVVNLYFGAFTGMMMLFYPEESRGLAQWGAGSLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHCCCCHHH
QESWRDSQWLLAQSAVGFCLVFSFIRPLTILTLNDSNAQSLGVPVGKLRLFAVIVSAYLI
HHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHHHH
AAVVSAVSMLGFIGLAAATIVRQLGVRTLAWQLISAFLVGALLLAITDLLLQLLNFYTQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SFPTGAVTALLGTPLLLWLMFRALPHSGRLTGEERKKQRRFRPHFTWLLIILFAVSLWLA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LNVGKSAFDQWSVLDFNHPFAPEILNLRYPRILIALCAGILLSVAGVLLQRLTLNPMASP
HHCCHHHHCCCCEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ELLGVSSGASMGILLLLFVFSAQQPLWFWLAGIGGALVALLILSAINRHNGMLPEKVLLT
CCEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
GISLSALFNTLQRIAIASGDPRANQLIAWTSGSTQNTTPELAVPFMGLSLVLLAGSLLFS
CCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RWLELLSLQAPMAQALGLNLKRARLLLILFSAVLTALATLMIGPLSFIGLLVPHLTYSLG
HHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VHKAKAQLLISALLGGTIMLLADWFGRQILFPYEIPAGLVATLLGGTYFLFILRKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]