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The map label for this gene is lysA [H]

Identifier: 148826629

GI number: 148826629

Start: 1672438

End: 1673790

Strand: Direct

Name: lysA [H]

Synonym: CGSHiEE_08490

Alternate gene names: 148826629

Gene position: 1672438-1673790 (Clockwise)

Preceding gene: 148826628

Following gene: 148826630

Centisome position: 92.25

GC content: 38.58

Gene sequence:

>1353_bases
ATGAATTTCTTCCAATATAAAAATAATAAGCTTTATGCTGAAGATATTCCGGTTCAACAACTTGCTGAACAATTTGGTAC
ACCTCTTTATGTATATTCTCGCGCGACACTTGAACGTCATTGGCACGCTTTTGACTCTGCTTTCGGTAAGCACCCTCACT
TAATTTGTTTTGCCGTAAAATCTTGCTCAAATATCGGCGTATTAAATATCATGGCAAAACTAGGTTCAGGTTTCGATATT
GTCTCGCAAGGCGAACTTGAGCGTGTACTGGCAGCAGGTGGCGATGCGTCAAAAGTGGTCTTTTCTGGCGTTGCGAAATC
TAGAGAAGAAATTATGCGTGCATTAGAAGTTGGAATCCGTTGCTTTAATGTGGAATCAGTTTCTGAACTCAAGCACATTA
ACCAAATCGCAGGAGAAATGGGTAAAATCGCACCTATTTCTTTACGTGTAAATCCAGATGTTGATGCACATACACACCCT
TATATTTCAACAGGATTAAAAGAAAATAAATTTGGTGTAAGCGTAAATGAAGCTCGAGAAGTGTATAAATTAGCCTCAAC
GCTACCAAACATAAAAATAACAGGGATGGATTGCCACATAGGCTCACAGCTTACCGAATTACAACCATTCTTAGATGCGA
CCGATCGATTAATTGTCCTAATGGAGCAATTAAAAGAAGATGGAATTACATTAAAACATCTCGATCTGGGCGGTGGTTTA
GGTGTGACTTATACGGATGAAACACCACCGCATCCAAGCGATTACGCAAATGCGTTATTAGAAAAACTAAAAAATTATCC
TGAACTTGAAATTATTCTTGAACCTGGCAGAGCAATTTCTGCCAATGCAGGAATTCTAGTAGCAAAAGTACAATACTTAA
AAAGTAATGAAAGCCGTAATTTCGCCATTACCGACACAGGAATGAACGATATGATCCGCCCAGCATTGTATGAGGCTTAC
ATGAACATCGTCGAAATTGACCGCACTTTAGAAAGAGAAAAAGCCATTTATGATGTTGTAGGGCCTGTTTGCGAAACGTC
TGATTTCTTAGGCAAACAACGGGAACTTTCAATTGCCGAAGGGGATTATATTGCTCAATGTTCTGCTGGTGCCTATGGAG
CAAGTATGTCATCAAACTATAACTCAAGAGCCCGCACTGCAGAAGTTTTTAGTAGATGGCGATCAATCCTATTTGATTCG
TCGCCGAGAAACCTTACAGGAACTTTGGGCATTAGAATCGACCATTTAATATTTCTTATCTTAAAAAAGAGCGGTAAAAA
ATTATCTATTTTTCTACCGCACTTTTTCTATTTTTATCCATCAATAAACCTACCTCAAATAGTAAGTTTTTGA

Upstream 100 bases:

>100_bases
TAAAAGGTTCTTTATATTTTCCTGAAAAAGATCAAGTTCAACAAACTCAATAATCTATTATCTAATATCATTCCCAAAAT
AACTAAAACAGGCACACAAC

Downstream 100 bases:

>100_bases
GATAAATCAAATTTTTTTCTATTCTAGATTGGCATAGAATTGAATTCTTTATAAAATGTCATGCTTTTTAAAGTGGACTT
CTAACCACTAAAGGGGAAAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MNFFQYKNNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKHPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVGIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILFDS
SPRNLTGTLGIRIDHLIFLILKKSGKKLSIFLPHFFYFYPSINLPQIVSF

Sequences:

>Translated_450_residues
MNFFQYKNNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKHPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVGIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILFDS
SPRNLTGTLGIRIDHLIFLILKKSGKKLSIFLPHFFYFYPSINLPQIVSF
>Mature_450_residues
MNFFQYKNNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKHPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVGIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILFDS
SPRNLTGTLGIRIDHLIFLILKKSGKKLSIFLPHFFYFYPSINLPQIVSF

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=350, Percent_Identity=24.8571428571429, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI22538418, Length=367, Percent_Identity=25.6130790190736, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21361583, Length=367, Percent_Identity=25.6130790190736, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI16506287, Length=345, Percent_Identity=24.9275362318841, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1789203, Length=410, Percent_Identity=31.219512195122, Blast_Score=158, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17562780, Length=364, Percent_Identity=23.3516483516484, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586474, Length=399, Percent_Identity=24.3107769423559, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 50045; Mature: 50045

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFQYKNNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKHPHLICFAVK
CCCEEECCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEC
SCSNIGVLNIMAKLGSGFDIVSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVGIR
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCE
CFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHPYISTGLKENKFGVSVNEARE
EECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
VYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRN
EEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEEEEHHHHCCCCCC
FAITDTGMNDMIRPALYEAYMNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAE
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCCCCEEECC
GDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILFDSSPRNLTGTLGIRIDHLIFLI
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHEE
LKKSGKKLSIFLPHFFYFYPSINLPQIVSF
ECCCCCEEEEEECHHHHHCCCCCCCHHHCC
>Mature Secondary Structure
MNFFQYKNNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKHPHLICFAVK
CCCEEECCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEC
SCSNIGVLNIMAKLGSGFDIVSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVGIR
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCE
CFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHPYISTGLKENKFGVSVNEARE
EECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
VYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRN
EEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEEEEHHHHCCCCCC
FAITDTGMNDMIRPALYEAYMNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAE
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCCCCEEECC
GDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILFDSSPRNLTGTLGIRIDHLIFLI
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHEE
LKKSGKKLSIFLPHFFYFYPSINLPQIVSF
ECCCCCEEEEEECHHHHHCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]