Click here to switch to the map view.

The map label for this gene is lpxD [H]

Identifier: 148826441

GI number: 148826441

Start: 1476625

End: 1477650

Strand: Direct

Name: lpxD [H]

Synonym: CGSHiEE_07440

Alternate gene names: 148826441

Gene position: 1476625-1477650 (Clockwise)

Preceding gene: 148826440

Following gene: 148826446

Centisome position: 81.45

GC content: 39.47

Gene sequence:

>1026_bases
ATGCAAAAATCCTATTCTTTACAAGAATTGGCAACTCAAATCGGCGCTACCGTTCGCGGTAACGCCGATGTTGTTGTTGA
GAATATCGCTCCTCTCGATAAAGCCCAATCAAATCAACTCACTTTTATTTCTAACGTAAAATTTCGTGCATTATTAAAAG
ATTCTAAAGCAGGGATTTTGGTTGTTTCTGAAGAGGATGTTGAACACTGTTCTCCAGAAAGCAATTTACTTATTGTTAAA
GATCCTTATGTAGCTTACGCAATTTTAGCTCAATATATGGATAGCACGCCAAAAGCTGCGCAAGGAATTGCACAAAGTGC
GGTCATTTTTGATGGCGTTTTATTAGGTAAAAATGTATCTATTGGTGCGAACGCAGTCATTGAAGAAGGCGTCACGCTAG
GCGATGACGTAATCATCGGGGCAAATTGTTTTGTTGGTAAAAATACCAAAATTGGTTCAGGCACTCAGCTCTGGGCTAAT
GTCACTGTTTACCATAACGTTGAGATTGGCGTAAATTGCTTAATTCAATCAGGAACAGTTATCGGTAGTGATGGTTTTGG
TTATGCAAATGATCGTGGTCGTTGGATTAAAATCCCACAAGTAGGGCAAGTAATAATTGGCAATAACGTTGAGATTGGTG
CGAATACCTGTATTGATAGAGGTGCATTAGACGCAACAATTATTGAAGATAACGTGATTATCGATAACCTTTGTCAAATT
GCGCATAATGTTCATATCGGCACTGGTACAGCGGTTGCAGGTGGCGTTATTATGGCAGGCAGTTTGACTGTAGGGCGTTA
TTGCTTAATTGGTGGTGCAAGTGTGATTAATGGTCATATGGAAATTTGTGATAAAGTAACCATTACTGGAATGGGAATGG
TAATGCGTCCAATCACAGAACCGGGCGTATATTCCTCTGGTATCCCATTACAAACGAATAAAGAGTGGCGTAAAACGGCA
GCTCTAACATTAGGCATTGATGGCATACATAAACGCCTAAAAGCATTAGAAAAGAAAATTTCTTAA

Upstream 100 bases:

>100_bases
AGTTGTATTTGCGGTAGAGGGTAAAGACATTACTGAAGAAGTATTAAAATCTATCCCTGCTTCTGAAAAAGCACAAGAGA
AAAAATAATAGGTTCTCATA

Downstream 100 bases:

>100_bases
TTGATACCCATCATTTAATCTGCATTTTAAAAGTTTAATAACTGATTAAAATGCAGATTTTTATGCGTATAAGTTTACTT
AACGAAATAAGTTGAAATTC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MQKSYSLQELATQIGATVRGNADVVVENIAPLDKAQSNQLTFISNVKFRALLKDSKAGILVVSEEDVEHCSPESNLLIVK
DPYVAYAILAQYMDSTPKAAQGIAQSAVIFDGVLLGKNVSIGANAVIEEGVTLGDDVIIGANCFVGKNTKIGSGTQLWAN
VTVYHNVEIGVNCLIQSGTVIGSDGFGYANDRGRWIKIPQVGQVIIGNNVEIGANTCIDRGALDATIIEDNVIIDNLCQI
AHNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEPGVYSSGIPLQTNKEWRKTA
ALTLGIDGIHKRLKALEKKIS

Sequences:

>Translated_341_residues
MQKSYSLQELATQIGATVRGNADVVVENIAPLDKAQSNQLTFISNVKFRALLKDSKAGILVVSEEDVEHCSPESNLLIVK
DPYVAYAILAQYMDSTPKAAQGIAQSAVIFDGVLLGKNVSIGANAVIEEGVTLGDDVIIGANCFVGKNTKIGSGTQLWAN
VTVYHNVEIGVNCLIQSGTVIGSDGFGYANDRGRWIKIPQVGQVIIGNNVEIGANTCIDRGALDATIIEDNVIIDNLCQI
AHNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEPGVYSSGIPLQTNKEWRKTA
ALTLGIDGIHKRLKALEKKIS
>Mature_341_residues
MQKSYSLQELATQIGATVRGNADVVVENIAPLDKAQSNQLTFISNVKFRALLKDSKAGILVVSEEDVEHCSPESNLLIVK
DPYVAYAILAQYMDSTPKAAQGIAQSAVIFDGVLLGKNVSIGANAVIEEGVTLGDDVIIGANCFVGKNTKIGSGTQLWAN
VTVYHNVEIGVNCLIQSGTVIGSDGFGYANDRGRWIKIPQVGQVIIGNNVEIGANTCIDRGALDATIIEDNVIIDNLCQI
AHNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEPGVYSSGIPLQTNKEWRKTA
ALTLGIDGIHKRLKALEKKIS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=338, Percent_Identity=65.3846153846154, Blast_Score=450, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36018; Mature: 36018

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKSYSLQELATQIGATVRGNADVVVENIAPLDKAQSNQLTFISNVKFRALLKDSKAGIL
CCCCCCHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCEEEEECCEEEEEEECCCCCEE
VVSEEDVEHCSPESNLLIVKDPYVAYAILAQYMDSTPKAAQGIAQSAVIFDGVLLGKNVS
EEECCCHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEECCCCC
IGANAVIEEGVTLGDDVIIGANCFVGKNTKIGSGTQLWANVTVYHNVEIGVNCLIQSGTV
CCCCHHHHCCCEECCCEEEECEEEECCCCCCCCCCEEEEEEEEEEEEEECEEEEEECCEE
IGSDGFGYANDRGRWIKIPQVGQVIIGNNVEIGANTCIDRGALDATIIEDNVIIDNLCQI
ECCCCCCCCCCCCCEEECCCCCEEEECCCEEECCCCCCCCCCCCEEEEECCCHHHHHHHH
AHNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITE
HHEEECCCCCHHHCCEEEECCCCCCCEEEECCHHHHCCHHHHHCEEEEECCCEEEECCCC
PGVYSSGIPLQTNKEWRKTAALTLGIDGIHKRLKALEKKIS
CCCCCCCCCCCCCHHHHHEEEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKSYSLQELATQIGATVRGNADVVVENIAPLDKAQSNQLTFISNVKFRALLKDSKAGIL
CCCCCCHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCEEEEECCEEEEEEECCCCCEE
VVSEEDVEHCSPESNLLIVKDPYVAYAILAQYMDSTPKAAQGIAQSAVIFDGVLLGKNVS
EEECCCHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEECCCCC
IGANAVIEEGVTLGDDVIIGANCFVGKNTKIGSGTQLWANVTVYHNVEIGVNCLIQSGTV
CCCCHHHHCCCEECCCEEEECEEEECCCCCCCCCCEEEEEEEEEEEEEECEEEEEECCEE
IGSDGFGYANDRGRWIKIPQVGQVIIGNNVEIGANTCIDRGALDATIIEDNVIIDNLCQI
ECCCCCCCCCCCCCEEECCCCCEEEECCCEEECCCCCCCCCCCCEEEEECCCHHHHHHHH
AHNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITE
HHEEECCCCCHHHCCEEEECCCCCCCEEEECCHHHHCCHHHHHCEEEEECCCEEEECCCC
PGVYSSGIPLQTNKEWRKTAALTLGIDGIHKRLKALEKKIS
CCCCCCCCCCCCCHHHHHEEEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA