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The map label for this gene is uppS

Identifier: 148826436

GI number: 148826436

Start: 1470539

End: 1471258

Strand: Direct

Name: uppS

Synonym: CGSHiEE_07415

Alternate gene names: 148826436

Gene position: 1470539-1471258 (Clockwise)

Preceding gene: 148826431

Following gene: 148826437

Centisome position: 81.11

GC content: 37.5

Gene sequence:

>720_bases
ATGATAGAGTTGGATCAAACAAATATACCAAAACACGTTGCCATTATTATGGATGGTAATGGTCGTTGGGCAAAACAGAA
AAATAAAATGCGAATTTTCGGACACACCAATGGCGTTACTGCGGTACGCAAAGCAGTGGCTTATGCACGACAAATCGGTG
TGGAAGTACTCACACTTTATGCCTTTAGTAGCGAAAATTGGAGTCGCCCAGAACAAGAAATCAGCGCGTTAATGTCGCTT
TTTATGCAAGCCTTGGATCGCGAAGTGAAAAAATTACATAAAAATAATATTTGTCTGAAAATTATTGGCGATGTATCTCG
TTTTAGTGAAACTTTACAAGAAAAAATCAAAAAAGCGGAAAATTTAACAGAAAAAAATACCGCGCTTACACTCAATATTG
CGGCAAATTACGGCGGTTGTTGGGATATTATTCAAGCCGCTAAACAAATTGCAGAAAAAGTTAAAAAAGAAGAAATGTCA
GTTTCAGATATTAATAACTCGACTTTTCAACATCATCTTGCAACCCAAAATGCACCACCTGTGGATTTATTAATTCGCAC
CAGTGGAGAACAGCGCATAAGCAACTTTTTATTATGGCAAATTGCCTATGCGGAATTATATTTTTCCGATGTGCTTTGGC
CTGATTTTAATCAATTAGAATTTAATCGCGCGATTGCAAGTTATCAACAACGTCATCGCCGTTTTGGCGGGACTGAATAG

Upstream 100 bases:

>100_bases
TTTACAGAACAGATTAGAACAAAGGAATTCATAGCAAGCCAATATAACTTATGATATAGTTTACCACCAAATTTATAGAG
GTCTCTCAATAATAAAAATA

Downstream 100 bases:

>100_bases
TTAAACGGATTAAAATTATGCTTAAACAACGAGTTTTATCTGCTATTGTGTTAATTGCTGCAGTTTTATGTGCACTATTT
TTATTCACACCTTTTTATTT

Product: hypothetical protein

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MIELDQTNIPKHVAIIMDGNGRWAKQKNKMRIFGHTNGVTAVRKAVAYARQIGVEVLTLYAFSSENWSRPEQEISALMSL
FMQALDREVKKLHKNNICLKIIGDVSRFSETLQEKIKKAENLTEKNTALTLNIAANYGGCWDIIQAAKQIAEKVKKEEMS
VSDINNSTFQHHLATQNAPPVDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNQLEFNRAIASYQQRHRRFGGTE

Sequences:

>Translated_239_residues
MIELDQTNIPKHVAIIMDGNGRWAKQKNKMRIFGHTNGVTAVRKAVAYARQIGVEVLTLYAFSSENWSRPEQEISALMSL
FMQALDREVKKLHKNNICLKIIGDVSRFSETLQEKIKKAENLTEKNTALTLNIAANYGGCWDIIQAAKQIAEKVKKEEMS
VSDINNSTFQHHLATQNAPPVDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNQLEFNRAIASYQQRHRRFGGTE
>Mature_239_residues
MIELDQTNIPKHVAIIMDGNGRWAKQKNKMRIFGHTNGVTAVRKAVAYARQIGVEVLTLYAFSSENWSRPEQEISALMSL
FMQALDREVKKLHKNNICLKIIGDVSRFSETLQEKIKKAENLTEKNTALTLNIAANYGGCWDIIQAAKQIAEKVKKEEMS
VSDINNSTFQHHLATQNAPPVDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNQLEFNRAIASYQQRHRRFGGTE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=227, Percent_Identity=36.5638766519824, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI45580742, Length=227, Percent_Identity=36.5638766519824, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=61.1353711790393, Blast_Score=306, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=37.6106194690265, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=35.6481481481481, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=33.953488372093, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=34.6666666666667, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_HAEIN (P44938)

Other databases:

- EMBL:   L42023
- PIR:   E64161
- RefSeq:   NP_439080.1
- ProteinModelPortal:   P44938
- SMR:   P44938
- GeneID:   950624
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0920
- TIGR:   HI_0920
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   CLSK870686
- BioCyc:   HINF71421:HI_0920-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27344; Mature: 27344

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 18-18

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELDQTNIPKHVAIIMDGNGRWAKQKNKMRIFGHTNGVTAVRKAVAYARQIGVEVLTLY
CCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEE
AFSSENWSRPEQEISALMSLFMQALDREVKKLHKNNICLKIIGDVSRFSETLQEKIKKAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHH
NLTEKNTALTLNIAANYGGCWDIIQAAKQIAEKVKKEEMSVSDINNSTFQHHLATQNAPP
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCCC
VDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNQLEFNRAIASYQQRHRRFGGTE
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELDQTNIPKHVAIIMDGNGRWAKQKNKMRIFGHTNGVTAVRKAVAYARQIGVEVLTLY
CCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEE
AFSSENWSRPEQEISALMSLFMQALDREVKKLHKNNICLKIIGDVSRFSETLQEKIKKAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHH
NLTEKNTALTLNIAANYGGCWDIIQAAKQIAEKVKKEEMSVSDINNSTFQHHLATQNAPP
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCCC
VDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNQLEFNRAIASYQQRHRRFGGTE
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800