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The map label for this gene is tktA [H]

Identifier: 148826345

GI number: 148826345

Start: 1365806

End: 1367803

Strand: Direct

Name: tktA [H]

Synonym: CGSHiEE_06900

Alternate gene names: 148826345

Gene position: 1365806-1367803 (Clockwise)

Preceding gene: 148826340

Following gene: 148826357

Centisome position: 75.33

GC content: 42.74

Gene sequence:

>1998_bases
ATGGCAACTCGTAGACAATTAGCCAATGCAATTCGTGTCTTAGCAATGGATTCTGTACAAAAAGCGAAATCTGGTCACCC
TGGTGCACCAATGGGGATGGCGGATATTGCTGAAGTGTTATGGCGCGACTTTTTAAAACACAATCCAACCAATCCTAAAT
GGGCTGATCGAGATCGTTTTGTACTTTCTAACGGCCATGGTTCTATGTTGATTTATAGTCTTTTACATTTAACTGGCTAT
GATCTTTCTATCGAAGATTTAAAACAATTCCGTCAATTACATTCTAAAACCCCTGGCCACCCAGAATATGGTTATGCGCC
CGGTGTTGAAACCACGACTGGCCCTCTTGGTCAAGGTATTACCAATGCTGTTGGTATGGCAATTGCAGAAAAAACACTTG
CAGGTCAATTTAACCGTGAAGGCCATGAAATTGTCGATCACCACACTTATGTGTTCTTAGGCGATGGCTGTTTAATGGAA
GGGATCTCTCACGAGGCTTGCTCTTTAGCGGGAACATTAGGTCTTGGCAAATTAATTGCATTCTACGATGACAATAATAT
TTCCATTGATGGTCATGTTGATGGCTGGTTCAGCGATGATACTGCAGCACGTTTTGAAGCTTATGGCTGGCAAGTAATTC
GTAATGTAGATGGTCACGATGCAGAGCAAATTCGTGCTGCTACCATTCTTGCTCAAGCAGAAAAAGAAAAACCAACGTTA
ATAATTTGTAAAACCATCATTGGTTTTGGTTCTCCAAATAAATCAGGCTCTCACGATAGCCACGGTGCGCCATTAGGCGA
TGAAGAAATCGCTTTAACTCGCAAAGCACTTGGTTGGGAATATGCGCCATTTGAAATTCCAGCTGAATACTATGCTGAAT
GGTCTGCAAAAGAGAAAGGCTCAGCAGCAGAAAAATCTTGGGAAGAAAAATTTGCCGCCTATGCAAAAGCCTATCCTGAA
TTAGCAGCAGAATTTAAACGTCGTGTTTCTGGCGAATTACCAACAAACTGGGCGGCAGAATCTAAAGTGTTCATCGAAAA
ATTACAAGCAAATCCAGCGAGTATTGCAAGCCGTAAAGCATCACAAAATGCCATTGAGGCTTATGCACACGTATTGCCAG
AATTTTTAGGAGGTTCTGCAGACTTAGCAAGCTCCAACTTAACCTTATGGAGTGGTTCAAAACCAATTCGTGCGCACGAA
AACGTAGGTGGTAACTACATTAACTACGGCGTTCGTGAATTTGGTATGTCTGCCATTATGAACGGTATTGCTTTACACGG
CGGTTTCATTCCTTACGGCGCAACCTTCTTAATGTTCTATGAATATGCTCACAATGCGGTGCGTATGGCAGCATTAATGA
AACAACGCACATTATTCGTTTATACCCACGATTCCATCGGTTTAGGCGAAGATGGGCCTACACACCAACCAGTAGAACAA
ACGGCTTCACTACGCTTAATTCCAAACCTTGAAACATGGCGTCCATGTGACCAAGTTGAATCAGCCATCGCATGGCAACA
AGCGGTTGAACGTCAAGATGGCCCAAGTGCGTTAATTTTCACTCGTCAAAATCTTGCTCAAATGAACCGCACTTCTGCAC
AATTAGATGCGGTTAAACGTGGTGCTTATGTGTTAAAAGACTGTGATGGCACACCTGAGTTAATTTTCATTGCGACAGGT
TCTGAAGTGGAATTAGCAGTGCAAGCAGCCGAAGCATTAAGTGCTGAAGGTAAAAAAGTACGCGTTGTTTCTATGCCAAG
TACTAACCGTTTCGATAAACAAGATGCAGCGTACCGTGAAAGCGTATTACCTGCAGCGGTAACCAAACGTGTTGCGATTG
AAGCGGGTATTGCTGACTTCTGGTATAAATACGTTGGATTCAATGGTCGTGTTGTCGGTATGAATAGCTTTGGCGAATCC
GCACCAGCAGATCAATTATTCAAACTCTTTGGTTTCACTGTTGAAAACGTGGTAGCAAAAGCGAAAGAAATTCTTTAA

Upstream 100 bases:

>100_bases
AAACTATTAAATTGAGTGCGGATTTTTGCTAAATTTCCTTCAGAAATAAGGTAGAATGCGCAAGATTATTTTTCAAAACG
AATTATCACAGGAGAACAAA

Downstream 100 bases:

>100_bases
GATTAAACTAAACTAGCTCCTTGATATTCAAGGAGCTTTTTTATTGGCTATTGAAAATTATTGTGAGATATGAAATAAAG
AAAGGAATAGATTTATACTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAARFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTL
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIALTRKALGWEYAPFEIPAEYYAEWSAKEKGSAAEKSWEEKFAAYAKAYPE
LAAEFKRRVSGELPTNWAAESKVFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHE
NVGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKRGAYVLKDCDGTPELIFIATG
SEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGES
APADQLFKLFGFTVENVVAKAKEIL

Sequences:

>Translated_665_residues
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAARFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTL
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIALTRKALGWEYAPFEIPAEYYAEWSAKEKGSAAEKSWEEKFAAYAKAYPE
LAAEFKRRVSGELPTNWAAESKVFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHE
NVGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKRGAYVLKDCDGTPELIFIATG
SEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGES
APADQLFKLFGFTVENVVAKAKEIL
>Mature_664_residues
ATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGYD
LSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEG
ISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAARFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTLI
ICKTIIGFGSPNKSGSHDSHGAPLGDEEIALTRKALGWEYAPFEIPAEYYAEWSAKEKGSAAEKSWEEKFAAYAKAYPEL
AAEFKRRVSGELPTNWAAESKVFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHEN
VGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQT
ASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKRGAYVLKDCDGTPELIFIATGS
EVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGESA
PADQLFKLFGFTVENVVAKAKEIL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=671, Percent_Identity=26.5275707898659, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI4507521, Length=671, Percent_Identity=26.5275707898659, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI133778974, Length=594, Percent_Identity=25.9259259259259, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI225637459, Length=678, Percent_Identity=20.9439528023599, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI225637461, Length=599, Percent_Identity=21.2020033388982, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637463, Length=599, Percent_Identity=21.2020033388982, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI48994911, Length=665, Percent_Identity=77.7443609022556, Blast_Score=1100, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=69.5324283559578, Blast_Score=999, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=672, Percent_Identity=24.702380952381, Blast_Score=162, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=49.2492492492492, Blast_Score=614, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=45.1420029895366, Blast_Score=565, Evalue=1e-162,
Organism=Drosophila melanogaster, GI45551847, Length=694, Percent_Identity=25.7925072046109, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45550715, Length=694, Percent_Identity=25.7925072046109, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24645119, Length=659, Percent_Identity=25.4931714719272, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24666278, Length=269, Percent_Identity=31.5985130111524, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72718; Mature: 72587

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFSDDTAARFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTL
EEECCCEEECCCCCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCE
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIALTRKALGWEYAPFEIPAEYYAEWSAKEKG
EEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCC
SAAEKSWEEKFAAYAKAYPELAAEFKRRVSGELPTNWAAESKVFIEKLQANPASIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
SQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHENVGGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHH
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHC
GAYVLKDCDGTPELIFIATGSEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRE
CCEEEECCCCCCCEEEEEECCCEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHH
SVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGESAPADQLFKLFGFTVENVVAK
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
AKEIL
HHHCC
>Mature Secondary Structure 
ATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFSDDTAARFEAYGWQVIRNVDGHDAEQIRAATILAQAEKEKPTL
EEECCCEEECCCCCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCE
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIALTRKALGWEYAPFEIPAEYYAEWSAKEKG
EEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCC
SAAEKSWEEKFAAYAKAYPELAAEFKRRVSGELPTNWAAESKVFIEKLQANPASIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
SQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHENVGGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHH
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMNRTSAQLDAVKR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHC
GAYVLKDCDGTPELIFIATGSEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRE
CCEEEECCCCCCCEEEEEECCCEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHH
SVLPAAVTKRVAIEAGIADFWYKYVGFNGRVVGMNSFGESAPADQLFKLFGFTVENVVAK
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
AKEIL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]