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The map label for this gene is serC [H]

Identifier: 148826222

GI number: 148826222

Start: 1228483

End: 1229571

Strand: Direct

Name: serC [H]

Synonym: CGSHiEE_06205

Alternate gene names: 148826222

Gene position: 1228483-1229571 (Clockwise)

Preceding gene: 148826220

Following gene: 148826225

Centisome position: 67.76

GC content: 38.57

Gene sequence:

>1089_bases
ATGTCACAAGTCTTTAATTTTAGCGCAGGCCCTGCGATGATTTTCCCAGAAGTGTTGCAAAAAGCACAAAATGAACTTAC
AAACTGGCTCAATCAAGGTGTTTCTGTAATGGAAGTAAGCCATCGCGGAAAGTATTTTATGGAACTCGTTACCCAAGCGG
AAAAAGATCTACGTGAGGTTTACAATATTCCTGATAACTATCGTGCACTTTTCTTACAAGGTGGTGCTCGCGGTCAATTT
GCCGCGATTCCGATGAACTTAATCGGTAAAAAAGGCAAAGCCCTTTATTTAAATAGTGGGCATTGGTCAGCTACAGCGGC
AAAAGAAGCAAGAAATTTTGCAGAAATTGATGAAATCACTATTGTAGAAAATGGCGAACAGACTCGAATTACCGATCTTG
ATTTTAGCCATATCGCTGATCAATATGACTACGTTCATTATTGCCCGAATGAAACCATCAGTGGTGTGGAGATTTTTGAT
GTGCCAAATGTAGGCAATGCCGTATTGGTCGCGGATATGTCTTCAAATATTCTTTCACGTCAAATCGATATCAGTAAATT
TGGTGTAATTTATGCTGGTGCGCAAAAAAATCTTGGCCCTGCGGGCATTACATTAGTCATTATTCGTGATGATTTAATCG
GTAATGCACGTAAAGAAACTCCCTCTATTTGGAATTATGCCACTCAACGTGATGCAAATTCAATGATCAACACGCCTCCA
ACTTTTGCGTGGTATTTATGTTCCCTCGTATTTAAACATCTTAAAGAAATAGGCGGCTTAGAAATAATCGAAAAACGTAA
TGCACTAAAAGCACAAACGCTTTATGATTATATTAATTCGAGCAAACTTTACCGCAATGTGGTAGCAAAAGAAAACCGCT
CAACAATGAATGTCACTTTCATCACAGGTAATCCTGAATTAGATGCAAAATTTGTCGCAGAATCTACTTCTGCGGGCTTG
CAAGCCTTGAAAGGTCATAAGGTTTTAGGTGGAATGCGTGCATCTATTTATAACGCAATGTCGCAAGATGGTGTTGAAGC
ACTTATTACATTTATGAAAAAATTTGAAGATGAAAATCTTCCTCAATAG

Upstream 100 bases:

>100_bases
GATAGAAAGAATTTTTTTGATTTCAGTAAAAAGCATTGATTATCGATTTTTGTAGTGATAAAAAAGACATCATTATTTTC
ATAAAAACCAAGGAAATACA

Downstream 100 bases:

>100_bases
TAAAATACATTTTCAATGGGCGTATTCGCTACGCCCAAATTTATTTGAAAATTCATACTAACCCATATCAATATTTACAA
ATAACACTATGCAGTACATC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRALFLQGGARGQF
AAIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFD
VPNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDANSMINTPP
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYINSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTSAGL
QALKGHKVLGGMRASIYNAMSQDGVEALITFMKKFEDENLPQ

Sequences:

>Translated_362_residues
MSQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRALFLQGGARGQF
AAIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFD
VPNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDANSMINTPP
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYINSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTSAGL
QALKGHKVLGGMRASIYNAMSQDGVEALITFMKKFEDENLPQ
>Mature_361_residues
SQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRALFLQGGARGQFA
AIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDV
PNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDANSMINTPPT
FAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYINSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTSAGLQ
ALKGHKVLGGMRASIYNAMSQDGVEALITFMKKFEDENLPQ

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine [H]

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily [H]

Homologues:

Organism=Homo sapiens, GI17402893, Length=360, Percent_Identity=45.8333333333333, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI10863955, Length=356, Percent_Identity=42.4157303370786, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=52.924791086351, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17506897, Length=357, Percent_Identity=43.4173669467787, Blast_Score=279, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=38.1818181818182, Blast_Score=239, Evalue=4e-64,
Organism=Drosophila melanogaster, GI21356589, Length=362, Percent_Identity=45.5801104972376, Blast_Score=303, Evalue=1e-82,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.6.1.52 [H]

Molecular weight: Translated: 40284; Mature: 40153

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHH
YNIPDNYRALFLQGGARGQFAAIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEIT
HCCCCCCEEEEEECCCCCCEEEECHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEE
IVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDVPNVGNAVLVADMSSNILSR
EEECCCCCEEECCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCCHHHHH
QIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDANSMINTPP
HCCHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYINSSKLYRNVVAKENRSTMNVTF
HHHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
ITGNPELDAKFVAESTSAGLQALKGHKVLGGMRASIYNAMSQDGVEALITFMKKFEDENL
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
PQ
CC
>Mature Secondary Structure 
SQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHH
YNIPDNYRALFLQGGARGQFAAIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEIT
HCCCCCCEEEEEECCCCCCEEEECHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEE
IVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDVPNVGNAVLVADMSSNILSR
EEECCCCCEEECCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCCHHHHH
QIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDANSMINTPP
HCCHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYINSSKLYRNVVAKENRSTMNVTF
HHHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
ITGNPELDAKFVAESTSAGLQALKGHKVLGGMRASIYNAMSQDGVEALITFMKKFEDENL
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
PQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]