Click here to switch to the map view.

The map label for this gene is prs [H]

Identifier: 148826134

GI number: 148826134

Start: 1138521

End: 1139468

Strand: Direct

Name: prs [H]

Synonym: CGSHiEE_05695

Alternate gene names: 148826134

Gene position: 1138521-1139468 (Clockwise)

Preceding gene: 148826133

Following gene: 148826137

Centisome position: 62.8

GC content: 42.83

Gene sequence:

>948_bases
ATGCCTGACATTAAACTCTTCGCGGGTAATGCTACACCTGAACTTGCAAAACGTATTTCTGAACGTTTATATATTTCACT
AGGCGATGCAACAGTCGCTCGTTTCAGCGATGGAGAAATTCAAGTTCAAATTAATGAAAATGTGCGTGGTGCGGATGTAT
TTATCATCCAATCAACTTGTGCGCCAACCAATGATAACTTGATGGAATTGGTTGTGATGGTAGATGCGTTACGTCGCGCA
TCTGCTGGTCGTATTACTGCCGTGATTCCCTATTTCGGCTATGCTCGCCAAGATCGTCGTGTTCGTTCTGCTCGTGTGCC
TATTACTGCTAAAGTTGTGGCAGATTTACTTTCAATTGTTGGTATTGACCGTGTCTTAACCTGCGACCTACACGCAGAAC
AAATCCAAGGTTTCTTTGATGTTCCCGTAGACAACGTATTTGGTTCGCCAGTTTTAATTCACGATATTTTGAAAAAATCT
GATCTTGAAAATCCAATTGTTGTTTCCCCAGATATTGGCGGCGTTGTGCGTGCTCGCGCTGTCGCTAAATTATTAAACGA
TACGGATATGGCTATTATTGACAAACGTCGCCCTCGTGCAAATGTAGCACAAGTGATGCATATTATCGGTGATATTGCAG
ACCGTGATTGTATTTTGGTTGATGATATGATTGATACTGGCGGTACGCTTTGTAAAGCGGCAGAAGCATTAAAAGAACGT
GGTGCAAAACGTGTTTTTGCTTATGCAACTCACGCCGTTTTCTCTGGTGCAGCAGCCAAAAATTTAGCCAGCGATGCCAT
TGATGAAGTTGTAGTTACTGACACGATTCCTCTATCAGAAGAAATGAAAGCGATCGGTAAAGTTCGCGTGCTTACGCTTT
CTTCCATGCTGGCAGAAGCCATTCGCCGCATTAGCAACGAAGAATCTATTTCTGCGATGTTTAACTAA

Upstream 100 bases:

>100_bases
TTCGTCGCTAAAGGACTCAATGTGTCTCCCTTGCACGCAATGTTGAAGCAGCTATCATCAACTCATACTCATCGACAATC
TAAACCTGAGGTTTTATAAA

Downstream 100 bases:

>100_bases
ATTAAAATTTCAATAAAAAATAACCGCACTTTTATTGCCAAAGTAGCGGTTATTTTTTTATCTATTTTATTCCACAGTCA
CACGCGCAAATTTTCGTTTA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTCAPTNDNLMELVVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIVGIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKS
DLENPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPRANVAQVMHIIGDIADRDCILVDDMIDTGGTLCKAAEALKER
GAKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEAIRRISNEESISAMFN

Sequences:

>Translated_315_residues
MPDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTCAPTNDNLMELVVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIVGIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKS
DLENPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPRANVAQVMHIIGDIADRDCILVDDMIDTGGTLCKAAEALKER
GAKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEAIRRISNEESISAMFN
>Mature_314_residues
PDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTCAPTNDNLMELVVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIVGIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKSD
LENPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPRANVAQVMHIIGDIADRDCILVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEAIRRISNEESISAMFN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=316, Percent_Identity=48.7341772151899, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI4506129, Length=316, Percent_Identity=48.4177215189873, Blast_Score=308, Evalue=3e-84,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=48.1132075471698, Blast_Score=308, Evalue=4e-84,
Organism=Homo sapiens, GI28557709, Length=316, Percent_Identity=48.7341772151899, Blast_Score=306, Evalue=1e-83,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=36.4431486880466, Blast_Score=197, Evalue=7e-51,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=36.1516034985423, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=29.6551724137931, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=29.6551724137931, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=29.6551724137931, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=29.6551724137931, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=85.3503184713376, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17554702, Length=316, Percent_Identity=47.1518987341772, Blast_Score=304, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI25149168, Length=316, Percent_Identity=47.1518987341772, Blast_Score=304, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI71989924, Length=316, Percent_Identity=47.1518987341772, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=46.6237942122186, Blast_Score=294, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=336, Percent_Identity=35.7142857142857, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=46.3258785942492, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321776, Length=317, Percent_Identity=47.6340694006309, Blast_Score=275, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=46.1783439490446, Blast_Score=271, Evalue=9e-74,
Organism=Saccharomyces cerevisiae, GI6322667, Length=206, Percent_Identity=42.7184466019417, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=113, Percent_Identity=40.7079646017699, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21355239, Length=316, Percent_Identity=47.7848101265823, Blast_Score=297, Evalue=7e-81,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=44.6745562130178, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.6478873239437, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.6478873239437, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.6478873239437, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.6478873239437, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=32.8877005347594, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=32.8877005347594, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=32.8877005347594, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34185; Mature: 34054

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTC
CCCCEEEECCCCHHHHHHHHHHEEEEECCCEEEEECCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
GIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKSDLENPIVVSPDIGGVVRARA
CCCCEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHH
VAKLLNDTDMAIIDKRRPRANVAQVMHIIGDIADRDCILVDDMIDTGGTLCKAAEALKER
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECHHCCCCHHHHHHHHHHHC
GAKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IRRISNEESISAMFN
HHHHCCCHHHHHHCC
>Mature Secondary Structure 
PDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTC
CCCEEEECCCCHHHHHHHHHHEEEEECCCEEEEECCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
GIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKSDLENPIVVSPDIGGVVRARA
CCCCEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHH
VAKLLNDTDMAIIDKRRPRANVAQVMHIIGDIADRDCILVDDMIDTGGTLCKAAEALKER
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECHHCCCCHHHHHHHHHHHC
GAKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IRRISNEESISAMFN
HHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA