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The map label for this gene is parE [H]

Identifier: 148826055

GI number: 148826055

Start: 1047306

End: 1049204

Strand: Direct

Name: parE [H]

Synonym: CGSHiEE_05215

Alternate gene names: 148826055

Gene position: 1047306-1049204 (Clockwise)

Preceding gene: 148826053

Following gene: 148826056

Centisome position: 57.77

GC content: 41.97

Gene sequence:

>1899_bases
ATGACAACCAATTATTCAGCTCAAGAAATTACCGTTCTTAAAGATCTCGAACCAGTGCAAATTCGCCCGGGAATGTACAC
TGACACTACTCGCCCTAATCATTTAGCACAAGAAGTTATTGATAACAGCGTAGATGAAGCCCTTGCCGGTTTTGCCTCAA
AAATTGAAGTAATTTTACACCCTGATCAATCCATTGAAGTAACGGACAATGGTCGCGGTATGCCTGTGGATACTCATCCT
ACGGAAGGCGTTTCTGGCGTAGAAGTAATCCTGACTAAACTGCATGCTGGTGGTAAATTCTCCAATAAAAATTATGAATT
TGCGGGAGGTTTACACGGTGTGGGGATTTCTGTGGTAAATGCGCTTTCTGAACGCGTGGATATTCAAGTCAAACGCAATG
GCGAAATCTATAAAATTGCCTTTGAAAACGGCAGTAAAGTAGAAGAATTGGAAATTATCGGGACTTGTGGTAGACGCACA
ACGGGAACAACCGTTCACTTCAAACCGAATCCAAAATATTTTGACAGCGCAAAATTTTCCGTTAGCCGCCTACGCCATTT
ATTAAGAGCGAAAGCGGTACTCTGCTCAGGGCTTGAAATCAAATTCATTGATAAAGTAAACAATACTCAAGACATTTGGT
TATATGAAGATGGGCTTTCCGATTACCTTATCGAAGCAGTAAATGGCTTTGAAACCCTTCCGGAAAAACCATTTGTTGGC
GAATTTAAAGGAACAAATGAAGCGGTTAGCTGGGCATTACTTTGGTTGCCAGAAGGTGGTGAACTGATTGGCGAAAGCTA
CGTAAACTTAATTCCAACAATTCAAGGCGGAACGCATGTTAATGGTCTACGTCAAGGTTTATTAGATGCCATTCGAGAAT
TTTGCGAATTTAGAAATCTATTACCACGCGGGGTAAAACTTACCGCCGATGATATTTGGGATCGTTGTTCTTACATTCTT
TCCCTTAAAATGCAGGATGCGCAATTCGCAGGGCAAACAAAGGAACGCTTATCATCACGCCAAAGTGCGGTGTTTGTCAG
CGGTGTTTTAAAAGATGCGTTCAGCCTATGGCTAAATCAAAATGTACAAGATGCTGAAAAATTAGCAGAAATTGCCATTA
GTTCTGCACAACGCCGATTACGCGCCGCCAAAAAAGTCGTGCGAAAAAAACTCGTTAGTGGCCCAGCATTACCAGGAAAA
TTAGCTGATTGTGGCTCACAGGATTTAGAAAAAACGGAATTATTTTTAGTGGAGGGCGACTCTGCTGGCGGCTCAGCAAA
ACAAGCACGTGATCGCGAATATCAAGCGATTTTGCCGTTACGTGGGAAAATCTTAAACACATGGGAAGTTTCCCCTGATC
AAGTATTAGGTTCAACCGAAATTCACGATATCGCCGTGGCTCTAGGGATCGATCCTGACAGCAATGATTTATCACAACTT
CGCTATGGTAAAGTCTGTATTCTCGCGGATGCTGACTCCGATGGTCTGCATATTGCCACCCTACTCTGCGCCCTGTTCTT
ACGTCATTTTCCGAAATTGGTACAAGACGGTCACGTTTACGTCGCAATGCCACCACTTTATCGCATTGACTTAAATAAAG
AAGTCTTCTACGCATTAGATGAAAATGAAAAAGAGGCGATTTTAGATCGGTTGAAAAACAAAAAAGGCAAACCGAATGTT
CAACGCTTTAAAGGTTTAGGTGAAATGAACCCATCGCAATTGCGTGAAACAACAATGGATCCTAATACGCGCCGTCTCGT
TCAATTAACTTATGATTTAGGGGAAGATCAAGGCTCAGATACATTAGAACTGATGGATATGTTATTAGCGAAAAAACGTT
CCGAAGACCGTAAAAATTGGTTACAAGCGAAAGGCGATCAGGTTGATTTATCTGTTTAG

Upstream 100 bases:

>100_bases
GAAAAGACGCCTAGTTTATACGATTAAAAGTGCGGTCGAATATCACCGCACTTTTTGATAGAATTTTCTCAAATTTAAAA
AATTAACGAATAACCTCACC

Downstream 100 bases:

>100_bases
ACTAAATTAATCTCAGCAAATCCGAATTTTAATAAATTAAGAATATATCAATTAACAGAAACAAAAATGACAAATATCAA
CTATGAAGGCATTGAGCAAA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MTTNYSAQEITVLKDLEPVQIRPGMYTDTTRPNHLAQEVIDNSVDEALAGFASKIEVILHPDQSIEVTDNGRGMPVDTHP
TEGVSGVEVILTKLHAGGKFSNKNYEFAGGLHGVGISVVNALSERVDIQVKRNGEIYKIAFENGSKVEELEIIGTCGRRT
TGTTVHFKPNPKYFDSAKFSVSRLRHLLRAKAVLCSGLEIKFIDKVNNTQDIWLYEDGLSDYLIEAVNGFETLPEKPFVG
EFKGTNEAVSWALLWLPEGGELIGESYVNLIPTIQGGTHVNGLRQGLLDAIREFCEFRNLLPRGVKLTADDIWDRCSYIL
SLKMQDAQFAGQTKERLSSRQSAVFVSGVLKDAFSLWLNQNVQDAEKLAEIAISSAQRRLRAAKKVVRKKLVSGPALPGK
LADCGSQDLEKTELFLVEGDSAGGSAKQARDREYQAILPLRGKILNTWEVSPDQVLGSTEIHDIAVALGIDPDSNDLSQL
RYGKVCILADADSDGLHIATLLCALFLRHFPKLVQDGHVYVAMPPLYRIDLNKEVFYALDENEKEAILDRLKNKKGKPNV
QRFKGLGEMNPSQLRETTMDPNTRRLVQLTYDLGEDQGSDTLELMDMLLAKKRSEDRKNWLQAKGDQVDLSV

Sequences:

>Translated_632_residues
MTTNYSAQEITVLKDLEPVQIRPGMYTDTTRPNHLAQEVIDNSVDEALAGFASKIEVILHPDQSIEVTDNGRGMPVDTHP
TEGVSGVEVILTKLHAGGKFSNKNYEFAGGLHGVGISVVNALSERVDIQVKRNGEIYKIAFENGSKVEELEIIGTCGRRT
TGTTVHFKPNPKYFDSAKFSVSRLRHLLRAKAVLCSGLEIKFIDKVNNTQDIWLYEDGLSDYLIEAVNGFETLPEKPFVG
EFKGTNEAVSWALLWLPEGGELIGESYVNLIPTIQGGTHVNGLRQGLLDAIREFCEFRNLLPRGVKLTADDIWDRCSYIL
SLKMQDAQFAGQTKERLSSRQSAVFVSGVLKDAFSLWLNQNVQDAEKLAEIAISSAQRRLRAAKKVVRKKLVSGPALPGK
LADCGSQDLEKTELFLVEGDSAGGSAKQARDREYQAILPLRGKILNTWEVSPDQVLGSTEIHDIAVALGIDPDSNDLSQL
RYGKVCILADADSDGLHIATLLCALFLRHFPKLVQDGHVYVAMPPLYRIDLNKEVFYALDENEKEAILDRLKNKKGKPNV
QRFKGLGEMNPSQLRETTMDPNTRRLVQLTYDLGEDQGSDTLELMDMLLAKKRSEDRKNWLQAKGDQVDLSV
>Mature_631_residues
TTNYSAQEITVLKDLEPVQIRPGMYTDTTRPNHLAQEVIDNSVDEALAGFASKIEVILHPDQSIEVTDNGRGMPVDTHPT
EGVSGVEVILTKLHAGGKFSNKNYEFAGGLHGVGISVVNALSERVDIQVKRNGEIYKIAFENGSKVEELEIIGTCGRRTT
GTTVHFKPNPKYFDSAKFSVSRLRHLLRAKAVLCSGLEIKFIDKVNNTQDIWLYEDGLSDYLIEAVNGFETLPEKPFVGE
FKGTNEAVSWALLWLPEGGELIGESYVNLIPTIQGGTHVNGLRQGLLDAIREFCEFRNLLPRGVKLTADDIWDRCSYILS
LKMQDAQFAGQTKERLSSRQSAVFVSGVLKDAFSLWLNQNVQDAEKLAEIAISSAQRRLRAAKKVVRKKLVSGPALPGKL
ADCGSQDLEKTELFLVEGDSAGGSAKQARDREYQAILPLRGKILNTWEVSPDQVLGSTEIHDIAVALGIDPDSNDLSQLR
YGKVCILADADSDGLHIATLLCALFLRHFPKLVQDGHVYVAMPPLYRIDLNKEVFYALDENEKEAILDRLKNKKGKPNVQ
RFKGLGEMNPSQLRETTMDPNTRRLVQLTYDLGEDQGSDTLELMDMLLAKKRSEDRKNWLQAKGDQVDLSV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=635, Percent_Identity=24.8818897637795, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI19913408, Length=627, Percent_Identity=25.9968102073365, Blast_Score=139, Evalue=9e-33,
Organism=Escherichia coli, GI1789408, Length=632, Percent_Identity=76.4240506329114, Blast_Score=1032, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=554, Percent_Identity=39.1696750902527, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535065, Length=629, Percent_Identity=26.2321144674086, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI212645845, Length=607, Percent_Identity=25.8649093904448, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI212645657, Length=230, Percent_Identity=28.2608695652174, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324241, Length=659, Percent_Identity=24.7344461305008, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17136538, Length=642, Percent_Identity=23.5202492211838, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 70167; Mature: 70036

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNYSAQEITVLKDLEPVQIRPGMYTDTTRPNHLAQEVIDNSVDEALAGFASKIEVILH
CCCCCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCEEEEEC
PDQSIEVTDNGRGMPVDTHPTEGVSGVEVILTKLHAGGKFSNKNYEFAGGLHGVGISVVN
CCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHH
ALSERVDIQVKRNGEIYKIAFENGSKVEELEIIGTCGRRTTGTTVHFKPNPKYFDSAKFS
HHHHHEEEEEECCCCEEEEEECCCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCHHH
VSRLRHLLRAKAVLCSGLEIKFIDKVNNTQDIWLYEDGLSDYLIEAVNGFETLPEKPFVG
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCC
EFKGTNEAVSWALLWLPEGGELIGESYVNLIPTIQGGTHVNGLRQGLLDAIREFCEFRNL
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
LPRGVKLTADDIWDRCSYILSLKMQDAQFAGQTKERLSSRQSAVFVSGVLKDAFSLWLNQ
CCCCCEEEHHHHHHHHHHHHHEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NVQDAEKLAEIAISSAQRRLRAAKKVVRKKLVSGPALPGKLADCGSQDLEKTELFLVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCEEEEEEECC
SAGGSAKQARDREYQAILPLRGKILNTWEVSPDQVLGSTEIHDIAVALGIDPDSNDLSQL
CCCCCHHHHCCCCCEEECCCCCCEEEEECCCHHHHCCCCCCEEEEEEEECCCCCCHHHHH
RYGKVCILADADSDGLHIATLLCALFLRHFPKLVQDGHVYVAMPPLYRIDLNKEVFYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCEEEEEEC
ENEKEAILDRLKNKKGKPNVQRFKGLGEMNPSQLRETTMDPNTRRLVQLTYDLGEDQGSD
CCCHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCC
TLELMDMLLAKKRSEDRKNWLQAKGDQVDLSV
HHHHHHHHHHHHCCHHHHHHHHCCCCEEECCC
>Mature Secondary Structure 
TTNYSAQEITVLKDLEPVQIRPGMYTDTTRPNHLAQEVIDNSVDEALAGFASKIEVILH
CCCCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCEEEEEC
PDQSIEVTDNGRGMPVDTHPTEGVSGVEVILTKLHAGGKFSNKNYEFAGGLHGVGISVVN
CCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHH
ALSERVDIQVKRNGEIYKIAFENGSKVEELEIIGTCGRRTTGTTVHFKPNPKYFDSAKFS
HHHHHEEEEEECCCCEEEEEECCCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCHHH
VSRLRHLLRAKAVLCSGLEIKFIDKVNNTQDIWLYEDGLSDYLIEAVNGFETLPEKPFVG
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCC
EFKGTNEAVSWALLWLPEGGELIGESYVNLIPTIQGGTHVNGLRQGLLDAIREFCEFRNL
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
LPRGVKLTADDIWDRCSYILSLKMQDAQFAGQTKERLSSRQSAVFVSGVLKDAFSLWLNQ
CCCCCEEEHHHHHHHHHHHHHEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NVQDAEKLAEIAISSAQRRLRAAKKVVRKKLVSGPALPGKLADCGSQDLEKTELFLVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCEEEEEEECC
SAGGSAKQARDREYQAILPLRGKILNTWEVSPDQVLGSTEIHDIAVALGIDPDSNDLSQL
CCCCCHHHHCCCCCEEECCCCCCEEEEECCCHHHHCCCCCCEEEEEEEECCCCCCHHHHH
RYGKVCILADADSDGLHIATLLCALFLRHFPKLVQDGHVYVAMPPLYRIDLNKEVFYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCEEEEEEC
ENEKEAILDRLKNKKGKPNVQRFKGLGEMNPSQLRETTMDPNTRRLVQLTYDLGEDQGSD
CCCHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCC
TLELMDMLLAKKRSEDRKNWLQAKGDQVDLSV
HHHHHHHHHHHHCCHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]