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The map label for this gene is trpC [H]

Identifier: 148825928

GI number: 148825928

Start: 945371

End: 946801

Strand: Direct

Name: trpC [H]

Synonym: CGSHiEE_04515

Alternate gene names: 148825928

Gene position: 945371-946801 (Clockwise)

Preceding gene: 148825927

Following gene: 148825929

Centisome position: 52.14

GC content: 39.41

Gene sequence:

>1431_bases
ATGATCACTCAAGATTTTACCAAACCCATTGATTCCGCTACGGTGCTACAAAAAATCGTGCTTGATAAAGCACAATGGGT
TAAAGCAAAAGAAAAGGAATTTCCCCTTTCACAATTTAAACAAAACATTCAAAACTCTGACCGCTCTTTTTATGATGCGT
TAGCAAAAGGTACGCATCAAAAGCCCGCTTACATTTTGGAATGTAAAAAAGCCTCTCCTTCTAAGGGATTAATTCGTGCT
GAATTTAATTTGGAGGAAATCGCCAATGTCTATAAACATTATGCGTCCGCTGTATCTGTTCTGACAGATGAAAAATACTT
CCAAGGCAATTTTGAGTTCTTGCCGTTAGTTCGCGGTATCGTGAGCCAACCTGTGCTTTGCAAAGATTTTATGATTAGCG
AATATCAAGTTTACCTTGCTCGCTACTATCAAGCGGATGCGATTTTATTAATGCTTTCTGTGGTAAACGATGAGACTTAT
CGTGTGCTGGCAGAGCTTGCGCATTCTCTTGGCATGGGCGTATTGACAGAAACCAGTAATGAAGAAGAATTTGAACGTGC
CCTTGCGCTTGGTGCGAAAATCATTGGTGTTAATAATCGTAACTTGCACGATTTAACTGTGGATTTAAATCGTGTTGTTG
AACTCACTGAAAAATACGCCGACTGTATTCCTGCTGATATACGTATTATTAGCGAATCAGGCATTTACAATCACAAGCAA
ATTCGTCAATTACAAAAAGTGGCGCATGGTTTCTTAATTGGGAGCAGCTTAATGGGCAACCAAGATTTGAATAATGCGGT
TCGCTCGGTAATTTTTGGAGAAAATAAAGTATGCGGTTTAACGCGCGCGCAAGATGTCAAAATCGTTTACGAAAACGGCG
CACTCTACGGCGGATTAATCTTCGCAGAACATTCAAAACGCTGTGTGAGTTTACGCCAAGCGCAAGAATTAGTAACCGCT
GCGCCACTTCGATTTGTTGGTGTTTTTCAGAATCAAGAAATTGACTTTATCGTCAAAATAGCCAACCAGTTACAGCTTTA
TGCGGTGCAATTACATGGTGCAGAAACTGAAGCATTTATTACCGCACTTCGCCAGCAACTACCAAAAAACACGCAAATTT
GGAAAGCTATTTCGGTCAATACTGAAGCCCAAAGTGCGGTCGATTTTACCGATAATTTAAATGTAGAACGTTATATTTTT
GATAGCCAAACATCGAACCAGCAAGGTGGCACGGGGAAAACTTTTGATTGGTCATTAATTCCTGAAAATCTTAAACACAA
GATTATTTTAGCTGGCGGCATTTCACCAAATAATGTGGAACAAGCCATTCAACAAAATTGCTTAGGCTTGGATATTAATT
CTGGGGTGGAAAGTTCTGCGGGCGTAAAAGATCAAGAAAAAGTGCGGTTAGTTTTTAATAATATTTATTAA

Upstream 100 bases:

>100_bases
CTGGCACATCTTGTATCAGGTAAAGCCTTTGAAACATTACAGAAATTAACCACATATTAATAAAAAGCTAATTTGATACA
CCACAATAAGAAGAAAAATG

Downstream 100 bases:

>100_bases
TTTTAATAACATAGAAATCACTAAATAACCAGAAATGTGCAACTATTGATCTAGATCCTAATAGTAAAATAAACCTATAT
TTCAGCTTAAATACCAATAG

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTHQKPAYILECKKASPSKGLIRA
EFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRGIVSQPVLCKDFMISEYQVYLARYYQADAILLMLSVVNDETY
RVLAELAHSLGMGVLTETSNEEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTEKYADCIPADIRIISESGIYNHKQ
IRQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGLIFAEHSKRCVSLRQAQELVTA
APLRFVGVFQNQEIDFIVKIANQLQLYAVQLHGAETEAFITALRQQLPKNTQIWKAISVNTEAQSAVDFTDNLNVERYIF
DSQTSNQQGGTGKTFDWSLIPENLKHKIILAGGISPNNVEQAIQQNCLGLDINSGVESSAGVKDQEKVRLVFNNIY

Sequences:

>Translated_476_residues
MITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTHQKPAYILECKKASPSKGLIRA
EFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRGIVSQPVLCKDFMISEYQVYLARYYQADAILLMLSVVNDETY
RVLAELAHSLGMGVLTETSNEEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTEKYADCIPADIRIISESGIYNHKQ
IRQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGLIFAEHSKRCVSLRQAQELVTA
APLRFVGVFQNQEIDFIVKIANQLQLYAVQLHGAETEAFITALRQQLPKNTQIWKAISVNTEAQSAVDFTDNLNVERYIF
DSQTSNQQGGTGKTFDWSLIPENLKHKIILAGGISPNNVEQAIQQNCLGLDINSGVESSAGVKDQEKVRLVFNNIY
>Mature_476_residues
MITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTHQKPAYILECKKASPSKGLIRA
EFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRGIVSQPVLCKDFMISEYQVYLARYYQADAILLMLSVVNDETY
RVLAELAHSLGMGVLTETSNEEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTEKYADCIPADIRIISESGIYNHKQ
IRQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGLIFAEHSKRCVSLRQAQELVTA
APLRFVGVFQNQEIDFIVKIANQLQLYAVQLHGAETEAFITALRQQLPKNTQIWKAISVNTEAQSAVDFTDNLNVERYIF
DSQTSNQQGGTGKTFDWSLIPENLKHKIILAGGISPNNVEQAIQQNCLGLDINSGVESSAGVKDQEKVRLVFNNIY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=462, Percent_Identity=55.4112554112554, Blast_Score=512, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322638, Length=226, Percent_Identity=37.6106194690265, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 53323; Mature: 53323

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTHQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCC
KPAYILECKKASPSKGLIRAEFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRGI
CCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
VSQPVLCKDFMISEYQVYLARYYQADAILLMLSVVNDETYRVLAELAHSLGMGVLTETSN
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCC
EEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTEKYADCIPADIRIISESGIYNHKQ
HHHHHHHHHHCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHH
IRQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGLI
HHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCCEECCCCCCCEEEEEECCCEEEEEE
FAEHSKRCVSLRQAQELVTAAPLRFVGVFQNQEIDFIVKIANQLQLYAVQLHGAETEAFI
EECCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHHHHEEEEEEEECCCHHHHH
TALRQQLPKNTQIWKAISVNTEAQSAVDFTDNLNVERYIFDSQTSNQQGGTGKTFDWSLI
HHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEC
PENLKHKIILAGGISPNNVEQAIQQNCLGLDINSGVESSAGVKDQEKVRLVFNNIY
CCCCCEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHEEECCC
>Mature Secondary Structure
MITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTHQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCC
KPAYILECKKASPSKGLIRAEFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRGI
CCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
VSQPVLCKDFMISEYQVYLARYYQADAILLMLSVVNDETYRVLAELAHSLGMGVLTETSN
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCC
EEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTEKYADCIPADIRIISESGIYNHKQ
HHHHHHHHHHCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHH
IRQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGLI
HHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCCEECCCCCCCEEEEEECCCEEEEEE
FAEHSKRCVSLRQAQELVTAAPLRFVGVFQNQEIDFIVKIANQLQLYAVQLHGAETEAFI
EECCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHHHHEEEEEEEECCCHHHHH
TALRQQLPKNTQIWKAISVNTEAQSAVDFTDNLNVERYIFDSQTSNQQGGTGKTFDWSLI
HHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEC
PENLKHKIILAGGISPNNVEQAIQQNCLGLDINSGVESSAGVKDQEKVRLVFNNIY
CCCCCEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]