Click here to switch to the map view.

The map label for this gene is sbcB [H]

Identifier: 148825925

GI number: 148825925

Start: 941692

End: 943248

Strand: Direct

Name: sbcB [H]

Synonym: CGSHiEE_04490

Alternate gene names: 148825925

Gene position: 941692-943248 (Clockwise)

Preceding gene: 148825924

Following gene: 148825926

Centisome position: 51.94

GC content: 38.92

Gene sequence:

>1557_bases
ATGAATATTCAAGCTCAAGCCTTTATTGCAGTGACAGCGCAACCCATTCCCTATTATGCTGACACCACCGCTATTTTTAA
TACACTTTGCCAACCAAATTCAAATTCTCTTCTACTCGATTCTGCCGAAATCGGGAGTAAAAACAGTTTACAAAGCCTTA
TCTTAGTCAATTCTGCGGTTAAAATAACGTGCTTAGGTCACAACGTCACATTTAAAGCATTAAATGAGAATGGAAAACAA
GTTTTAAAAGAAATTTATCCAAAATTAACCGCACTTGGAAAAATAAGTGCGGTCAATTTTGAAGACGAATTTTCTGTACA
ATTTTCGCCACTTGATAATCAACTCGATGAAGATAGCAAATTACAATCTGCCACTATTTTTGATGGATTGCGTGTTATTT
CTACTCTTTATCAACATAGCCAAACGCCTATTTTCTTAGGCGGATTGTTTGCTTACGATCTCGTCGCAAATTTCATTCCA
ATGGATGGCATTACATTACAACATGATGGTATCAACTGCCCTGATTACAGTTTCTATCTTGCCGAACACTTAATTACTAT
CGACCATCAAAATCAACAAGCGACACTCAAAAGTTTCTGTTTTGCTCAAGAAGAACAAGTCAATATTGCGAAAACCTCGC
TTTCTATCGCGCAAAAACTAAAAAATATTGATAACGTTCTTTCTATTAAAGCAGCAAGTGATGAAGTTAAAACAAACTTT
GACGATCCTGAATTTACCGGCATCGTGAAAGCCTTAAAGCACCATATTAACATTGGTGATGTTTTCCAAATTGTACCTTC
TCGCCGTTTTTCCCTTGCTTGCCCGAATACATTAGCCAGTTACGCCCAACTCAAACAAAATAATCCAAGCCCTTATATGT
TCTATATGAATGATGAAGACTTTATTTTGTTTGGTGCATCGCCAGAAAGTGCACTGAAATATGAACCTGAAAATCGTCAA
TTAGAAATTTACCCAATCGCAGGTTCTCGCCCTCGTGGTTTTGATGCTCACGGCAATATTGATCCTGAATTGGATGCACG
TTTAGAACTAGAACTTCGCCTTGATCACAAAGAACAAGCGGAACATTTAATGTTGGTTGATTTAGCGCGTAACGACATTG
CTCGAGTTTGCCAAAGTGGTACCCGTAAAGTGGCTGAATTAATGCAAGTAGATCGTTATTCTCACATTATGCATTTAGTG
TCTCGAGTGGTGGGTAAATTACGCCCTGAGTTAGATGCACTTCACGCCTATCAAGCCTGTATGAATATGGGCACATTAAC
TGGTGCGCCAAAAATCAAAGCAATGCAGCTTATTTATCAATTTGAGCAACAAAAACGCCATAGTTACGGTGGTGCGGTGG
GTTATCTCACGTCCGATGGACATTTTGATACCTGTATCGTAATCCGTTCTGCTTTTGTACAAAATGGGATAGCCCATGTG
CAAGCAGGTTGCGGCGAAGTATTAGATTCTGATCCACAAATGGAAGCCGATGAAACACGTCACAAAGCCGCAGCTGTCTT
AAAAGCAATTCGTCAAGTTAATACACAAGCAAAATAA

Upstream 100 bases:

>100_bases
CACATTTTTTAATCAAAAAACATAAAAAATTAAAATCAGGCTTGACTTATTCCTTTTGCACTAGTTTAATAGTACAAAAT
TTCCAAAAGGATAAATAAAT

Downstream 100 bases:

>100_bases
GGAAGAATTATTATGGCTAATATTTTATTTTTAGATAACTTTGATTCTTTCACTTACAACCTTGTGGATCAATTCCGTGT
ATTGGGTCACAACGTCACAA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MNIQAQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNSAVKITCLGHNVTFKALNENGKQ
VLKEIYPKLTALGKISAVNFEDEFSVQFSPLDNQLDEDSKLQSATIFDGLRVISTLYQHSQTPIFLGGLFAYDLVANFIP
MDGITLQHDGINCPDYSFYLAEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
DDPEFTGIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDEDFILFGASPESALKYEPENRQ
LEIYPIAGSRPRGFDAHGNIDPELDARLELELRLDHKEQAEHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLV
SRVVGKLRPELDALHAYQACMNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
QAGCGEVLDSDPQMEADETRHKAAAVLKAIRQVNTQAK

Sequences:

>Translated_518_residues
MNIQAQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNSAVKITCLGHNVTFKALNENGKQ
VLKEIYPKLTALGKISAVNFEDEFSVQFSPLDNQLDEDSKLQSATIFDGLRVISTLYQHSQTPIFLGGLFAYDLVANFIP
MDGITLQHDGINCPDYSFYLAEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
DDPEFTGIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDEDFILFGASPESALKYEPENRQ
LEIYPIAGSRPRGFDAHGNIDPELDARLELELRLDHKEQAEHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLV
SRVVGKLRPELDALHAYQACMNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
QAGCGEVLDSDPQMEADETRHKAAAVLKAIRQVNTQAK
>Mature_518_residues
MNIQAQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNSAVKITCLGHNVTFKALNENGKQ
VLKEIYPKLTALGKISAVNFEDEFSVQFSPLDNQLDEDSKLQSATIFDGLRVISTLYQHSQTPIFLGGLFAYDLVANFIP
MDGITLQHDGINCPDYSFYLAEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
DDPEFTGIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDEDFILFGASPESALKYEPENRQ
LEIYPIAGSRPRGFDAHGNIDPELDARLELELRLDHKEQAEHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLV
SRVVGKLRPELDALHAYQACMNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
QAGCGEVLDSDPQMEADETRHKAAAVLKAIRQVNTQAK

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=504, Percent_Identity=52.5793650793651, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1788114, Length=366, Percent_Identity=30.6010928961749, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87082077, Length=271, Percent_Identity=28.0442804428044, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786809, Length=228, Percent_Identity=30.7017543859649, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=379, Percent_Identity=36.6754617414248, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6324361, Length=391, Percent_Identity=24.0409207161125, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57601; Mature: 57601

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQAQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNSAV
CCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHEEECCCE
KITCLGHNVTFKALNENGKQVLKEIYPKLTALGKISAVNFEDEFSVQFSPLDNQLDEDSK
EEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCCCCHH
LQSATIFDGLRVISTLYQHSQTPIFLGGLFAYDLVANFIPMDGITLQHDGINCPDYSFYL
HHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHH
AEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
HHHEEEEECCCHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHCCC
DDPEFTGIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDED
CCHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCC
FILFGASPESALKYEPENRQLEIYPIAGSRPRGFDAHGNIDPELDARLELELRLDHKEQA
EEEECCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHH
EHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLVSRVVGKLRPELDALHAYQAC
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHH
QAGCGEVLDSDPQMEADETRHKAAAVLKAIRQVNTQAK
HHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIQAQAFIAVTAQPIPYYADTTAIFNTLCQPNSNSLLLDSAEIGSKNSLQSLILVNSAV
CCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHEEECCCE
KITCLGHNVTFKALNENGKQVLKEIYPKLTALGKISAVNFEDEFSVQFSPLDNQLDEDSK
EEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCCCCHH
LQSATIFDGLRVISTLYQHSQTPIFLGGLFAYDLVANFIPMDGITLQHDGINCPDYSFYL
HHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHH
AEHLITIDHQNQQATLKSFCFAQEEQVNIAKTSLSIAQKLKNIDNVLSIKAASDEVKTNF
HHHEEEEECCCHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHCCC
DDPEFTGIVKALKHHINIGDVFQIVPSRRFSLACPNTLASYAQLKQNNPSPYMFYMNDED
CCHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCC
FILFGASPESALKYEPENRQLEIYPIAGSRPRGFDAHGNIDPELDARLELELRLDHKEQA
EEEECCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHH
EHLMLVDLARNDIARVCQSGTRKVAELMQVDRYSHIMHLVSRVVGKLRPELDALHAYQAC
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MNMGTLTGAPKIKAMQLIYQFEQQKRHSYGGAVGYLTSDGHFDTCIVIRSAFVQNGIAHV
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHH
QAGCGEVLDSDPQMEADETRHKAAAVLKAIRQVNTQAK
HHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]