Click here to switch to the map view.

The map label for this gene is nhaA [H]

Identifier: 148825491

GI number: 148825491

Start: 369087

End: 370289

Strand: Direct

Name: nhaA [H]

Synonym: CGSHiEE_01950

Alternate gene names: 148825491

Gene position: 369087-370289 (Clockwise)

Preceding gene: 148825489

Following gene: 148825493

Centisome position: 20.36

GC content: 36.58

Gene sequence:

>1203_bases
GTGAATTTTTTGCTATGTATTTTTAAAGGGGTTTATGTGATAAAACTGATCCAACGTTTTTTTAAATTAGAATCTGCTGG
CGGTATATTATTGCTTTTTTCAGCTGTTGTTGCGATGTTGCTGGCTAATTCGCCGTTAAGCAACCAATATAATGATTTTT
TAAATTTGCCTGTAAGTTTACAAATTGGTAGTTTCTCAATTAATAAAACCTTAATTCACTGGATTAACGATGGTTTTATG
GCGGTGTTTTTTGTATTAGTGGGAATGGAAGTCAAAAAAGAATTATTTGAAGGCGCGCTTTCTACCTATCAACAAGCTAT
TTTCCCTGCTATTGCAGCTATTGGCGGAATGGTTATACCGGCTGTAGTTTATTGGTTTATCGCTAAACAAGATCCCAGTT
TAGCTAATGGCTGGGCAATTCCAATGGCAACAGACATTGCTTTTGCACTGGGAATTATGGCGTTATTGAGTAAACAAGTG
CCACTTCCACTGAAAATATTTTTACTTGCCCTTGCTATTATTGATGACCTCGGTGCGATAGTTGTTATTGCATTATTTTT
CTCGCACGGATTGAGTGTACAAGCACTAATTTTTTCTGCCGTGGCAATTATTGCGCTGATATTACTAAATCGTTTCAAAG
TTTCCGCACTTTGCGCTTATATGGTCGTAGGTGCAATTTTATGGGCTTCCGTATTAAAGTCTGGTGTGCACGCTACTTTA
GCAGGCGTTATTATTGGTTTTAGCATTCCATTGAAAGGTAAGAAAGGAGAACGCCCATTAGATGATTTCGAGCATATTTT
AGCCTCTTGGTCATCTTTCGTTATTTTACCACTTTTCGCATTTGCCAATGCTGGTGTGAGTTTTGCAGGCATAGATGTGA
ATATGATTTCGTCGCCATTATTATTGGCTATAGCAAGCGGCTTAATTATTGGTAAACCAGTCGGTATATTTGGATTTAGT
TATATTTCTGTTAAATTGGGATTAGCTAAATTACCAGATGGAATTAATTTTAAACAAATTTTTGCTGTTGCGGTTTTATG
TGGAATCGGTTTTACGATGTCAATGTTCTTAGCAAGCCTTGCGTTTGATGCTAATGCGGGGGAAAGTGTTAATACGCTTT
CTCGTTTAGGTATTCTATTTGGATCAACTGTTTCGGCAATACTTGGTTATTTATTCTTAAAACAGACGACAAAACTAAGT
TAA

Upstream 100 bases:

>100_bases
GTCACAATATATGGCATTTTATCGACAATTCGCTAAAAATCCCGACAAAATCTACCGCACTTTTTCCTTTAACTTCGAAA
ATATGCTAGGATGCCCCTTT

Downstream 100 bases:

>100_bases
TCATACACAAAGTGCGGTAAAAATTTACCGCACTTGTTCTATAAGATAATTCCACTATCTGCTTTGGTAAAATTCATTAC
AAATAAACTTTTATAAGTTC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSLQIGSFSINKTLIHWINDGFM
AVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIPAVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQV
PLPLKIFLLALAIIDDLGAIVVIALFFSHGLSVQALIFSAVAIIALILLNRFKVSALCAYMVVGAILWASVLKSGVHATL
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPLLLAIASGLIIGKPVGIFGFS
YISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASLAFDANAGESVNTLSRLGILFGSTVSAILGYLFLKQTTKLS

Sequences:

>Translated_400_residues
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSLQIGSFSINKTLIHWINDGFM
AVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIPAVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQV
PLPLKIFLLALAIIDDLGAIVVIALFFSHGLSVQALIFSAVAIIALILLNRFKVSALCAYMVVGAILWASVLKSGVHATL
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPLLLAIASGLIIGKPVGIFGFS
YISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASLAFDANAGESVNTLSRLGILFGSTVSAILGYLFLKQTTKLS
>Mature_400_residues
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSLQIGSFSINKTLIHWINDGFM
AVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIPAVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQV
PLPLKIFLLALAIIDDLGAIVVIALFFSHGLSVQALIFSAVAIIALILLNRFKVSALCAYMVVGAILWASVLKSGVHATL
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPLLLAIASGLIIGKPVGIFGFS
YISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASLAFDANAGESVNTLSRLGILFGSTVSAILGYLFLKQTTKLS

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=388, Percent_Identity=53.8659793814433, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 42715; Mature: 42715

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEE
QIGSFSINKTLIHWINDGFMAVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIP
EECCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQVPLPLKIFLLALAIIDDLGAI
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VVIALFFSHGLSVQALIFSAVAIIALILLNRFKVSALCAYMVVGAILWASVLKSGVHATL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPL
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH
LLAIASGLIIGKPVGIFGFSYISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASL
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AFDANAGESVNTLSRLGILFGSTVSAILGYLFLKQTTKLS
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEE
QIGSFSINKTLIHWINDGFMAVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIP
EECCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQVPLPLKIFLLALAIIDDLGAI
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VVIALFFSHGLSVQALIFSAVAIIALILLNRFKVSALCAYMVVGAILWASVLKSGVHATL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPL
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH
LLAIASGLIIGKPVGIFGFSYISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASL
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AFDANAGESVNTLSRLGILFGSTVSAILGYLFLKQTTKLS
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA