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The map label for this gene is fba [H]

Identifier: 148825202

GI number: 148825202

Start: 69047

End: 70126

Strand: Direct

Name: fba [H]

Synonym: CGSHiEE_00370

Alternate gene names: 148825202

Gene position: 69047-70126 (Clockwise)

Preceding gene: 148825201

Following gene: 148825203

Centisome position: 3.81

GC content: 40.46

Gene sequence:

>1080_bases
ATGGCTAAATTATTAGATATCGTGAAACCCGGTGTTATAACAGGCGAAGATGTGCAAAAAGTTTTTGCTTATGCTAAAGA
GCATAACTTTGCTATTCCTGCCGTAAACTGTGTGGGTTCTGACTCCGTTAATGCCGTGTTAGAAACTGCTGCACGCGTAA
AAGCACCAGTGATTATCCAATTTTCAAATGGTGGCGCAGCGTTCTATGCAGGTAAAGGTATCAAACCAACGAGTGGTACT
CGTCCAGATGTTTTAGGGGCGATTGCTGGAGCGAAACAGGTTCATACTTTAGCGAAAGAATACGGTGTGCCTGTTATTCT
TCATACTGATCACGCAGCGAAAAAATTATTACCTTGGATCGACGGTTTATTAGATGCAGGCGAAAAACATTTTGCTGAAA
CGGGTCGTCCACTTTTCTCTTCACATATGATTGATTTATCTGAAGAGCCAATGGAAGAAAATATGGCAATCTGCCGTGAA
TATCTTGCTCGTATGGATAAAATGGGGATGACCCTTGAAATCGAAATTGGCATTACTGGTGGCGAAGAAGACGGCGTAGA
TAACTCTGATGTTGATGAATCACGTTTATATACACAACCTTCTGATGTGCTTTATGTTTACGATCAATTGCATCCAGTAA
GCCCTAACTTTACCGTTGCTGCTGCATTCGGTAACGTACATGGTGTTTACAAACCAGGTAATGTAAAATTAAAACCATCT
ATTTTAGGTGCATCACAAGAGTTCGTTTCTAAAGAACGCAATCTTCCTGCAAAACCAATTAATTTCGTATTCCACGGTGG
TTCAGGTTCTAGCCGCGAAGAAATCCGCGAAGCAATTGGCTACGGTGCAATCAAAATGAACATTGATACCGATACCCAAT
GGGCATCTTGGAATGGTATTTTGAACTTCTACAAAGCAAATGAAGCATATCTTCAAGGTCAATTAGGTAACCCTGAAGGC
CCAGATGCACCAAACAAAAAATACTACGACCCACGTGTTTGGTTACGTAAAATGGAAGAATCTATGTCTAAACGCTTAGA
GCAATCTTTCGAAGACTTAAATTGTGTTGATGTTTTATAA

Upstream 100 bases:

>100_bases
CCTCTATAACATATTGATGGTGGCATCAAAAATGCCATCATCAATACAAATTCTTCAAATTGTGGGCTTATCCCGCTAAA
CATAAAAAGGAAACACAAGT

Downstream 100 bases:

>100_bases
TCCACAAAAATAACATAAAATAACGACCGCACTTTCAAGTGCGGTTTTTTTATTTTAGCGGAGAAATTATGGAAAAGATT
TTAGTTATTCGTAACGATAA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGT
RPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEEPMEENMAICRE
YLARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
ILGASQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEG
PDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL

Sequences:

>Translated_359_residues
MAKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGT
RPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEEPMEENMAICRE
YLARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
ILGASQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEG
PDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
>Mature_358_residues
AKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGTR
PDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEEPMEENMAICREY
LARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPSI
LGASQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEGP
DAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=359, Percent_Identity=71.3091922005571, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI87082041, Length=331, Percent_Identity=26.8882175226586, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788072, Length=274, Percent_Identity=26.2773722627737, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322790, Length=352, Percent_Identity=50.8522727272727, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 39306; Mature: 39175

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00152 ATPASE_ALPHA_BETA ; PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQ
CCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFYAGKGIKPTSGTRPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWI
ECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
DGLLDAGEKHFAETGRPLFSSHMIDLSEEPMEENMAICREYLARMDKMGMTLEIEIGITG
HHHHHCCHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
CCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHH
ILGASQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGI
HHCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCE
LNFYKANEAYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKLLDIVKPGVITGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQ
CHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFYAGKGIKPTSGTRPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWI
ECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
DGLLDAGEKHFAETGRPLFSSHMIDLSEEPMEENMAICREYLARMDKMGMTLEIEIGITG
HHHHHCCHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
CCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHH
ILGASQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGI
HHCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCE
LNFYKANEAYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]