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The map label for this gene is ureC

Identifier: 148825187

GI number: 148825187

Start: 52603

End: 54321

Strand: Direct

Name: ureC

Synonym: CGSHiEE_00295

Alternate gene names: 148825187

Gene position: 52603-54321 (Clockwise)

Preceding gene: 148825186

Following gene: 148825188

Centisome position: 2.9

GC content: 44.21

Gene sequence:

>1719_bases
ATGGCATTAACAATTTCAAGAGCACAATATGTAGCAACTTATGGCCCAACCGTTGGCGATAAAGTCCGTTTAGGCGATAC
CAATTTATGGGCAACCATTGAACAAGATTTATTGACCAAAGGTGATGAGTGTAAATTTGGTGGCGGTAAAAGCGTGCGTG
ATGGTATGGCTCAAAGCGGTACGGCAACTCGCGACAATCCGAATGTATTGGATTTTGTGATTACCAACGTGATGATCATT
GATGCTAAATTAGGCATTATCAAAGCAGATATTGGTATTCGTGATGGGCGTATTGTGGGCATTGGACAAGCAGGTAACCC
TGACACCATGGATAACGTCACGCCAAACATGATTATCGGTGCTAGCACAGAAGTTCATAACGGTGCACATTTAATTGCAA
CCGCTGGCGGTATTGATACCCACATTCACTTTATTTGTCCGCAACAAGCACAACATGCGATTGAAAGTGGCGTTACCACG
TTAATTGGCGGTGGGACTGGCCCTGCTGATGGTACGCACGCAACCACTTGTACCCCTGGCGCATGGTATATGGAACGTAT
GTTTCAAGCGGCAGAAGCCTTGCCTGTAAACGTCGGATTTTTTGGTAAAGGCAACTGTTCAACCCTAGATCCTCTGCGTG
AGCAAATTGAAGCGGGTGCATTAGGTTTAAAAATCCACGAAGACTGGGGTGCAACGCCTGCCGTGATTGATTCTGCCTTA
AAAGTAGCAGATGAAATGGATATTCAAGTGGCCATTCACACAGACACGCTAAATGAAAGTGGCTTTTTGGAAGACACGAT
GAAAGCGATTGATGGACGTGTCATTCATACTTTCCATACGGAGGGCGCAGGTGGTGGTCATGCACCTGACATCATTAAAG
CAGCGATGTATTCAAACGTATTACCTGCTTCAACCAACCCGACTCGTCCGTTTACCAAAAACACCATTGATGAACATTTG
GATATGTTGATGGTTTGCCATCACTTAGATAAACGCGTGCCGGAAGACGTAGCTTTTGCCGATAGCCGTATCCGCCCTGA
AACCATTGCAGCAGAAGATATTTTGCATGATATGGGCGTCTTCTCCATTATGAGTTCAGACTCTCAAGCAATGGGACGTA
TTGGAGAAGTCGTTATTCGTACATGGCAAACTGCAGATAAGATGAAAATGCAACGTGGTGAGCTAGGTAATGAAGGAAAC
GATAACTTCCGTATTAAACGCTACATTGCGAAATATACTATCAACCCAGCAATTGCACATGGTATTGCGGAGCATATTGG
CTCGTTAGAAGTGGGTAAAATCGCAGATATCGTGTTATGGAAACCGATGTTCTTTGGGGTAAAACCTGAAGTCGTCATTA
AAAAAGGTTTTATTAGCTACGCCAAAATGGGCGACCCAAATGCCTCAATTCCAACGCCACAACCTGTATTCTACCGTCCA
ATGTACGGTGCACAAGGCTTAGCAACGGCACAAACAGCGGTATTTTTTGTTTCACAAGCCGCTGAAAAAGCCGATATTCG
TGAAAAATTCGGTTTACACAAAGAAACCATTGCTGTGAAAGGCTGCCGCAACGTAGGTAAAAAAGATCTGGTTCATAATG
ATGTAACACCAAACATTACTGTTGATGCTGAACGTTATGAAGTTCGAGTGGATGGAGAGTTAATTACCTGTGAACCAGTG
GATAGCGTACCATTGGGTCAGCGATATTTCCTATTCTAA

Upstream 100 bases:

>100_bases
CAGGTGAAGTGAAATCAGTAGAATTAGTTGCTTTTGGTGGTAACCAAATCATTTATGGTTTCCATAATCAAATTGATGGC
AAATTATAAGGTAGGGCAGA

Downstream 100 bases:

>100_bases
AGGACTGTTTTCATAGACGAATTAGTGTAAAAAGGCGTGTACGATACGCCTCTTACTTGATAAATAAGAAATCATTGTAG
CTGTAGTTTTTCTTTCGAAG

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MALTISRAQYVATYGPTVGDKVRLGDTNLWATIEQDLLTKGDECKFGGGKSVRDGMAQSGTATRDNPNVLDFVITNVMII
DAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIGASTEVHNGAHLIATAGGIDTHIHFICPQQAQHAIESGVTT
LIGGGTGPADGTHATTCTPGAWYMERMFQAAEALPVNVGFFGKGNCSTLDPLREQIEAGALGLKIHEDWGATPAVIDSAL
KVADEMDIQVAIHTDTLNESGFLEDTMKAIDGRVIHTFHTEGAGGGHAPDIIKAAMYSNVLPASTNPTRPFTKNTIDEHL
DMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGVFSIMSSDSQAMGRIGEVVIRTWQTADKMKMQRGELGNEGN
DNFRIKRYIAKYTINPAIAHGIAEHIGSLEVGKIADIVLWKPMFFGVKPEVVIKKGFISYAKMGDPNASIPTPQPVFYRP
MYGAQGLATAQTAVFFVSQAAEKADIREKFGLHKETIAVKGCRNVGKKDLVHNDVTPNITVDAERYEVRVDGELITCEPV
DSVPLGQRYFLF

Sequences:

>Translated_572_residues
MALTISRAQYVATYGPTVGDKVRLGDTNLWATIEQDLLTKGDECKFGGGKSVRDGMAQSGTATRDNPNVLDFVITNVMII
DAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIGASTEVHNGAHLIATAGGIDTHIHFICPQQAQHAIESGVTT
LIGGGTGPADGTHATTCTPGAWYMERMFQAAEALPVNVGFFGKGNCSTLDPLREQIEAGALGLKIHEDWGATPAVIDSAL
KVADEMDIQVAIHTDTLNESGFLEDTMKAIDGRVIHTFHTEGAGGGHAPDIIKAAMYSNVLPASTNPTRPFTKNTIDEHL
DMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGVFSIMSSDSQAMGRIGEVVIRTWQTADKMKMQRGELGNEGN
DNFRIKRYIAKYTINPAIAHGIAEHIGSLEVGKIADIVLWKPMFFGVKPEVVIKKGFISYAKMGDPNASIPTPQPVFYRP
MYGAQGLATAQTAVFFVSQAAEKADIREKFGLHKETIAVKGCRNVGKKDLVHNDVTPNITVDAERYEVRVDGELITCEPV
DSVPLGQRYFLF
>Mature_571_residues
ALTISRAQYVATYGPTVGDKVRLGDTNLWATIEQDLLTKGDECKFGGGKSVRDGMAQSGTATRDNPNVLDFVITNVMIID
AKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIGASTEVHNGAHLIATAGGIDTHIHFICPQQAQHAIESGVTTL
IGGGTGPADGTHATTCTPGAWYMERMFQAAEALPVNVGFFGKGNCSTLDPLREQIEAGALGLKIHEDWGATPAVIDSALK
VADEMDIQVAIHTDTLNESGFLEDTMKAIDGRVIHTFHTEGAGGGHAPDIIKAAMYSNVLPASTNPTRPFTKNTIDEHLD
MLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGVFSIMSSDSQAMGRIGEVVIRTWQTADKMKMQRGELGNEGND
NFRIKRYIAKYTINPAIAHGIAEHIGSLEVGKIADIVLWKPMFFGVKPEVVIKKGFISYAKMGDPNASIPTPQPVFYRPM
YGAQGLATAQTAVFFVSQAAEKADIREKFGLHKETIAVKGCRNVGKKDLVHNDVTPNITVDAERYEVRVDGELITCEPVD
SVPLGQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_HAEI8 (Q4QN09)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248248.1
- ProteinModelPortal:   Q4QN09
- SMR:   Q4QN09
- STRING:   Q4QN09
- GeneID:   3429975
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0665
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   HINF281310:NTHI0665-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61835; Mature: 61704

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3; PS00024 HEMOPEXIN

Important sites: ACT_SITE 327-327 BINDING 226-226

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTISRAQYVATYGPTVGDKVRLGDTNLWATIEQDLLTKGDECKFGGGKSVRDGMAQSG
CEEEECCCEEEEECCCCCCCEEEECCCCEEEEEHHHHHCCCCCCCCCCCCHHHHCHHHCC
TATRDNPNVLDFVITNVMIIDAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIG
CCCCCCCCHHHHHHHCEEEEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEE
ASTEVHNGAHLIATAGGIDTHIHFICPQQAQHAIESGVTTLIGGGTGPADGTHATTCTPG
CCCCCCCCEEEEEECCCCCEEEEEECCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCH
AWYMERMFQAAEALPVNVGFFGKGNCSTLDPLREQIEAGALGLKIHEDWGATPAVIDSAL
HHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
KVADEMDIQVAIHTDTLNESGFLEDTMKAIDGRVIHTFHTEGAGGGHAPDIIKAAMYSNV
HHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHCC
LPASTNPTRPFTKNTIDEHLDMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
FSIMSSDSQAMGRIGEVVIRTWQTADKMKMQRGELGNEGNDNFRIKRYIAKYTINPAIAH
HHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEEEHHHCCCHHHHH
GIAEHIGSLEVGKIADIVLWKPMFFGVKPEVVIKKGFISYAKMGDPNASIPTPQPVFYRP
HHHHHHCCCCHHHHHHHEEECHHHCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCEEECC
MYGAQGLATAQTAVFFVSQAAEKADIREKFGLHKETIAVKGCRNVGKKDLVHNDVTPNIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHHCCCHHHHCCCCCCCCEE
VDAERYEVRVDGELITCEPVDSVPLGQRYFLF
EECCEEEEEECCEEEEECCCCCCCCCCEECCC
>Mature Secondary Structure 
ALTISRAQYVATYGPTVGDKVRLGDTNLWATIEQDLLTKGDECKFGGGKSVRDGMAQSG
EEEECCCEEEEECCCCCCCEEEECCCCEEEEEHHHHHCCCCCCCCCCCCHHHHCHHHCC
TATRDNPNVLDFVITNVMIIDAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIG
CCCCCCCCHHHHHHHCEEEEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEE
ASTEVHNGAHLIATAGGIDTHIHFICPQQAQHAIESGVTTLIGGGTGPADGTHATTCTPG
CCCCCCCCEEEEEECCCCCEEEEEECCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCH
AWYMERMFQAAEALPVNVGFFGKGNCSTLDPLREQIEAGALGLKIHEDWGATPAVIDSAL
HHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
KVADEMDIQVAIHTDTLNESGFLEDTMKAIDGRVIHTFHTEGAGGGHAPDIIKAAMYSNV
HHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHCC
LPASTNPTRPFTKNTIDEHLDMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
FSIMSSDSQAMGRIGEVVIRTWQTADKMKMQRGELGNEGNDNFRIKRYIAKYTINPAIAH
HHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEEEHHHCCCHHHHH
GIAEHIGSLEVGKIADIVLWKPMFFGVKPEVVIKKGFISYAKMGDPNASIPTPQPVFYRP
HHHHHHCCCCHHHHHHHEEECHHHCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCEEECC
MYGAQGLATAQTAVFFVSQAAEKADIREKFGLHKETIAVKGCRNVGKKDLVHNDVTPNIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHHCCCHHHHCCCCCCCCEE
VDAERYEVRVDGELITCEPVDSVPLGQRYFLF
EECCEEEEEECCEEEEECCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA