Click here to switch to the map view.

The map label for this gene is gnd [H]

Identifier: 148825170

GI number: 148825170

Start: 40687

End: 42141

Strand: Direct

Name: gnd [H]

Synonym: CGSHiEE_00210

Alternate gene names: 148825170

Gene position: 40687-42141 (Clockwise)

Preceding gene: 148825169

Following gene: 148825173

Centisome position: 2.24

GC content: 42.27

Gene sequence:

>1455_bases
ATGTCAGTAAAAGGCGACATCGGTGTTATCGGCTTAGCCGTAATGGGGCAAAACCTCATTTTAAATATGAACGACCACGG
GTTTAAAGTCGTGGCATATAACCGTACCACTTCAAAAGTGGATGAGTTTTTACAAGGTGCGGCAAAAGGCACGAATATTA
TCGGCGCATACTCTTTAGAAGATTTAGCTGCTAAATTAGAAAAACCACGTAAAGTGATGTTAATGGTGCGCGCAGGTGAT
GTGGTGGATCAATTCATTGAAGCATTATTACCACATTTAGAAGAGGGCGACATCATTATTGATGGCGGTAACTCAAACTA
TCCAGATACGAACCGTCGAGTGAAAGCCTTGGCGGAGAAAGGTATTCGCTTTATCGGTTCGGGTGTGTCTGGTGGCGAAG
AAGGGGCGCGTCACGGGCCTTCAATTATGCCAGGTGGTAATCAAGAAGCATGGCAATATGTGAAACCAATTTTCCAAGCA
ATCTCAGCTAAAACAGAACAAGGCGAACCTTGCTGTGACTGGGTTGGCGGTGAAGGCGCTGGCCACTTTGTGAAAATGGT
TCACAACGGTATCGAATATGGCGATATGCAATTAATCTGTGAAGCTTACCAATTCTTAAAAGAAGGTTTAGGCTTGAGCT
ATGACGAAATGCAAGCCATCTTCGCAGAATGGAAAAATACTGAACTTGATAGCTATTTAATCGATATCACCACTGACATT
CTTGGCTATAAAGATGCAAGTGGAGAACCTTTAGTCGAAAAAATCTTGGATACTGCGGGTCAAAAAGGGACAGGTAAATG
GACAGGTATCAATGCGTTAGATTTTGGTATTCCATTAACTTTAATCACTGAATCCGTTTTTGCACGCTGCGTGTCTTCCT
TTAAAGATCAACGTGTTGCGGCTAATCAATTATTCGGCAAAACTATTACACCAGTTGAAGGCGACAAAAAAGTATGGATT
GAAGCGGTACGTAAGGCATTATTAGCGTCAAAAATTATTTCTTACGCACAAGGCTTTATGCTGATTCGTGAAGCCTCTGA
ACAATTTGGTTGGGATATTAACTATGGTGCAACTGCGTTGTTATGGCGTGAAGGTTGTATCATTCGTAGCCGTTTCTTAG
GTAATATTCGCGATGCTTATGAAGCAAATCCAAATCTTGTTTTCTTAGGTTCAGATAGCTACTTCAAAGGCATTTTAGAA
AACGCATTAAGTGACTGGCGTAAAGTGGTGGCAAAATCTATCGAAGTGGGTATCCCAATGCCTTGTATGGCGTCTGCGAT
TACTTTCTTAGATGGCTATACTTCAGCACGTTTACCAGCAAACTTATTGCAAGCACAACGCGACTACTTCGGTGCTCATA
CTTATGAACGCACAGATAAACCTCGTGGCGAGTTTTTCCACACCAACTGGACTGGTCGTGGCGGTAATATAGCATCAACT
ACTTATGATGTGTAG

Upstream 100 bases:

>100_bases
CATCCATCTAGTAGAACAAAGAATTCTGTGATTGCGTTAAAAGAACTTCGAAAAATCTTGAAATCAAAGACAATGAATTA
AATAAAAACAGGAGAAAACA

Downstream 100 bases:

>100_bases
TTAAAAACATCAATAAGAATTACCGCACTTTAAACTATTGCTATAAATTTGGATAGTTTATTAATTTGCTGAAATATTGG
GCTCTGCATAATGTAGAGCT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGD
VVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQA
ISAKTEQGEPCCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYDEMQAIFAEWKNTELDSYLIDITTDI
LGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAANQLFGKTITPVEGDKKVWI
EAVRKALLASKIISYAQGFMLIREASEQFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILE
NALSDWRKVVAKSIEVGIPMPCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNIAST
TYDV

Sequences:

>Translated_484_residues
MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGD
VVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQA
ISAKTEQGEPCCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYDEMQAIFAEWKNTELDSYLIDITTDI
LGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAANQLFGKTITPVEGDKKVWI
EAVRKALLASKIISYAQGFMLIREASEQFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILE
NALSDWRKVVAKSIEVGIPMPCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNIAST
TYDV
>Mature_483_residues
SVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGDV
VDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAI
SAKTEQGEPCCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYDEMQAIFAEWKNTELDSYLIDITTDIL
GYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAANQLFGKTITPVEGDKKVWIE
AVRKALLASKIISYAQGFMLIREASEQFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILEN
ALSDWRKVVAKSIEVGIPMPCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNIASTT
YDV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=481, Percent_Identity=62.1621621621622, Blast_Score=623, Evalue=1e-178,
Organism=Escherichia coli, GI1788341, Length=467, Percent_Identity=53.3190578158458, Blast_Score=506, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17542558, Length=483, Percent_Identity=60.4554865424431, Blast_Score=615, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6321695, Length=486, Percent_Identity=58.8477366255144, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6321977, Length=488, Percent_Identity=58.8114754098361, Blast_Score=571, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24639279, Length=483, Percent_Identity=59.8343685300207, Blast_Score=576, Evalue=1e-164,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53139; Mature: 53008

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLE
CCCCCCCCCEEHEECCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCHH
DLAAKLEKPRKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEK
HHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
GIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGA
CHHEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCH
GHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYDEMQAIFAEWKNTELDSYLIDITTDI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVA
HCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ANQLFGKTITPVEGDKKVWIEAVRKALLASKIISYAQGFMLIREASEQFGWDINYGATAL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILENALSDWRKVVAKSIEVGIPM
EHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNIAST
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
TYDV
CCCC
>Mature Secondary Structure 
SVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLE
CCCCCCCCEEHEECCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCHH
DLAAKLEKPRKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEK
HHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
GIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGA
CHHEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCH
GHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYDEMQAIFAEWKNTELDSYLIDITTDI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVA
HCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ANQLFGKTITPVEGDKKVWIEAVRKALLASKIISYAQGFMLIREASEQFGWDINYGATAL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILENALSDWRKVVAKSIEVGIPM
EHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNIAST
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
TYDV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]