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The map label for this gene is eccD1

Identifier: 148825085

GI number: 148825085

Start: 4368103

End: 4369542

Strand: Direct

Name: eccD1

Synonym: TBFG_13912

Alternate gene names: 148825085

Gene position: 4368103-4369542 (Clockwise)

Preceding gene: 148825084

Following gene: 148825086

Centisome position: 98.73

GC content: 64.1

Gene sequence:

>1440_bases
ATGACCGATTTGGTACTGCCAGCGGCGGTGCCGATGGAAACTTATATTGACGACACCGTCGCGGTGCTTTCCGAGGTGTT
GGAAGACACGCCGGCTGATGTACTCGGCGGCTTCGACTTTACCGCGCAAGGCGTGTGGGCGTTCGCTCGTCCCGGATCGC
CGCCGCTGAAGCTCGACCAGTCACTCGATGACGCCGGGGTGGTCGACGGGTCACTGCTGACTCTGGTGTCAGTCAGTCGC
ACCGAGCGCTACCGACCGTTGGTCGAGGATGTCATCGACGCGATCGCCGTGCTTGACGAGTCACCTGAGTTCGACCGCAC
GGCATTGAATCGCTTTGTGGGGGCGGCGATCCCGCTTTTGACCGCGCCCGTCATCGGGATGGCGATGCGGGCGTGGTGGG
AAACTGGGCGTAGCTTGTGGTGGCCGTTGGCGATTGGCATCCTGGGGATCGCTGTGCTGGTAGGCAGCTTCGTCGCGAAC
AGGTTCTACCAGAGCGGCCACCTGGCCGAGTGCCTACTGGTCACGACGTATCTGCTGATCGCAACCGCCGCAGCGCTGGC
CGTGCCGTTGCCGCGCGGGGTCAACTCGTTGGGGGCGCCACAAGTTGCCGGCGCCGCTACGGCCGTGCTGTTTTTGACCT
TGATGACGCGGGGCGGCCCTCGGAAGCGTCATGAGTTGGCGTCGTTTGCCGTGATCACCGCTATCGCGGTCATCGCGGCC
GCCGCTGCCTTCGGCTATGGATACCAGGACTGGGTCCCCGCGGGGGGGATCGCATTCGGGCTGTTCATTGTGACGAATGC
GGCCAAGCTGACCGTCGCGGTCGCGCGGATCGCGCTGCCGCCGATTCCGGTACCCGGCGAAACCGTGGACAACGAGGAGT
TGCTCGATCCCGTCGCGACCCCGGAGGCTACCAGCGAAGAAACCCCGACCTGGCAGGCCATCATCGCGTCGGTGCCCGCG
TCCGCGGTCCGGCTCACCGAGCGCAGCAAACTGGCCAAGCAACTTCTCATCGGATACGTCACGTCGGGCACCCTGATTCT
GGCTGCCGGTGCCATCGCGGTCGTGGTGCGCGGGCACTTCTTTGTACACAGCCTGGTGGTCGCGGGTTTGATCACGACCG
TCTGCGGATTTCGCTCGCGGCTTTACGCCGAGCGCTGGTGTGCGTGGGCGTTGCTGGCGGCGACGGTCGCGATTCCGACG
GGTCTGACGGCCAAACTCATCATCTGGTACCCGCACTATGCCTGGCTGTTGTTGAGCGTCTACCTCACGGTAGCCCTGGT
TGCGCTCGTGGTGGTCGGGTCGATGGCTCACGTCCGGCGCGTTTCACCGGTCGTAAAACGAACTCTGGAATTGATCGACG
GCGCCATGATCGCTGCCATCATTCCCATGCTGCTGTGGATCACCGGGGTGTACGACACGGTCCGCAATATCCGGTTCTGA

Upstream 100 bases:

>100_bases
GTCGTTGAGCGCACCTGCTGTTGCTGCTGGTCCTACCGCCGCGGGGGCAACCGCTGCGCGGCCTGCCACCACCCGGGTGA
CGATCCTGACCGGCAGACGG

Downstream 100 bases:

>100_bases
GCCGGATCGGCTGATTGGCGGTTCCTGACAGAACATCGAGGACACGGCGCAGGTTTGCATACCTTCGGCGCCCGACAAAT
TGCTGCGATTGAGCGTGTGG

Product: transmembrane protein

Products: NA

Alternate protein names: ESX conserved component D1; Type VII secretion system protein eccD1; T7SS protein eccD1

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSR
TERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVAN
RFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAA
AAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPA
SAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPT
GLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF

Sequences:

>Translated_479_residues
MTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSR
TERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVAN
RFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAA
AAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPA
SAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPT
GLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF
>Mature_478_residues
TDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRT
ERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANR
FYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAAA
AAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPAS
AVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTG
LTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as esxA (ESAT-6) and esxB (CFP-10). Responsible for multiple suppressive effects on macrophages and required for bacterial replication after phagocytosis

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eccD/snm4 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCD1_MYCTU (O69741)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   C70803
- RefSeq:   NP_218394.1
- RefSeq:   NP_338545.1
- EnsemblBacteria:   EBMYCT00000001420
- EnsemblBacteria:   EBMYCT00000069455
- GeneID:   886207
- GeneID:   926640
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3991
- KEGG:   mtu:Rv3877
- TIGR:   MT3991
- TubercuList:   Rv3877
- GeneTree:   EBGT00050000016341
- HOGENOM:   HBG565400
- OMA:   VVQGHFF
- ProtClustDB:   CLSK792779
- InterPro:   IPR006707
- TIGRFAMs:   TIGR02958

Pfam domain/function: PF04600 DUF571

EC number: NA

Molecular weight: Translated: 50952; Mature: 50821

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1e54be50)-; HASH(0x1e9d9aa0)-; HASH(0x1e4f99d8)-; HASH(0x1e402a00)-; HASH(0x1e5df750)-; HASH(0x1ea95724)-; HASH(0x1ebf5cf4)-; HASH(0x1e0be280)-; HASH(0x1e7010fc)-; HASH(0x1e3af7b4)-; HASH(0x1dda5548)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCCCCCCC
SLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAA
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVAT
HHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCC
PEATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHF
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
FVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLLSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHH
YLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
TDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCCCCCCC
SLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAA
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVAT
HHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCC
PEATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHF
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
FVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLLSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHH
YLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036