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The map label for this gene is ppe68

Identifier: 148825081

GI number: 148825081

Start: 4364075

End: 4365181

Strand: Direct

Name: ppe68

Synonym: TBFG_13908

Alternate gene names: 148825081

Gene position: 4364075-4365181 (Clockwise)

Preceding gene: 148825080

Following gene: 148825082

Centisome position: 98.64

GC content: 67.48

Gene sequence:

>1107_bases
ATGCTGTGGCACGCAATGCCACCGGAGCTAAATACCGCACGGCTGATGGCCGGCGCGGGTCCGGCTCCAATGCTTGCGGC
GGCCGCGGGATGGCAGACGCTTTCGGCGGCTCTGGACGCTCAGGCCGTCGAGTTGACCGCGCGCCTGAACTCTCTGGGAG
AAGCCTGGACTGGAGGTGGCAGCGACAAGGCGCTTGCGGCTGCAACGCCGATGGTGGTCTGGCTACAAACCGCGTCAACA
CAGGCCAAGACCCGTGCGATGCAGGCGACGGCGCAAGCCGCGGCATACACCCAGGCCATGGCCACGACGCCGTCGCTGCC
GGAGATCGCCGCCAACCACATCACCCAGGCCGTCCTTACGGCCACCAACTTCTTCGGTATCAACACGATCCCGATCGCGT
TGACCGAGATGGATTATTTCATCCGTATGTGGAACCAGGCAGCCCTGGCAATGGAGGTCTACCAGGCCGAGACCGCGGTT
AACACGCTTTTCGAGAAGCTCGAGCCGATGGCGTCGATCCTTGATCCCGGCGCGAGCCAGAGCACGACGAACCCGATCTT
CGGAATGCCCTCCCCTGGCAGCTCAACACCGGTTGGCCAGTTGCCGCCGGCGGCTACCCAGACCCTCGGCCAACTGGGTG
AGATGAGCGGCCCGATGCAGCAGCTGACCCAGCCGCTGCAGCAGGTGACGTCGTTGTTCAGCCAGGTGGGCGGCACCGGC
GGCGGCAACCCAGCCGACGAGGAAGCCGCGCAGATGGGCCTGCTCGGCACCAGTCCGCTGTCGAACCATCCGCTGGCTGG
TGGATCAGGCCCCAGCGCGGGCGCGGGCCTGCTGCGCGCGGAGTCGCTACCTGGCGCAGGTGGGTCGTTGACCCGCACGC
CGCTGATGTCTCAGCTGATCGAAAAGCCGGTTGCCCCCTCGGTGATGCCGGCGGCTGCTGCCGGATCGTCGGCGACGGGT
GGCGCCGCTCCGGTGGGTGCGGGAGCGATGGGCCAGGGTGCGCAATCCGGCGGCTCCACCAGGCCGGGTCTGGTCGCGCC
GGCACCGCTCGCGCAGGAGCGTGAAGAAGACGACGAGGACGACTGGGACGAAGAGGACGACTGGTGA

Upstream 100 bases:

>100_bases
AGCGGTCCAGGACGTCGCCCGCACCTATTCGCAAATCGACGACGGCGCCGCCGGCGTCTTCGCCTAATAGGCCCCCAACA
CATCGGAGGGCGTGATCACC

Downstream 100 bases:

>100_bases
GCTCCCGTAATGACAACAGACTTCCCGGCCACCCGGGCCGGAAGACTTGCCAACATTTTGGCGAGGAAGGTAAAGAGAGA
AAGTAGTCCAGCATGGCAGA

Product: PPE family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATPMVVWLQTAST
QAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAV
NTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTG
GGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATG
GAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW

Sequences:

>Translated_368_residues
MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATPMVVWLQTAST
QAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAV
NTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTG
GGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATG
GAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW
>Mature_368_residues
MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATPMVVWLQTAST
QAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAV
NTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTG
GGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATG
GAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW

Specific function: Stimulates high levels of gamma interferon secretion in peripheral blood mononuclear cells isolated from tuberculosis patients, as well as from healthy tuberculin purified protein derivative-positive donors. Does not interfere with the secretion and prese

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall. Cell membrane. Note=Detected predominantly in the membrane and cell wall fractions

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPE68_MYCTU (Q79F92)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   G70802
- RefSeq:   NP_338541.1
- RefSeq:   YP_178022.1
- HSSP:   Q79FE1
- ProteinModelPortal:   Q79F92
- SMR:   Q79F92
- EnsemblBacteria:   EBMYCT00000002401
- EnsemblBacteria:   EBMYCT00000070695
- GeneID:   886201
- GeneID:   926287
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3987
- KEGG:   mtu:Rv3873
- TIGR:   MT3987
- TubercuList:   Rv3873
- GeneTree:   EBGT00050000014875
- HOGENOM:   HBG572308
- OMA:   EMDYFVR
- ProtClustDB:   CLSK2301112
- InterPro:   IPR000030

Pfam domain/function: PF00823 PPE

EC number: NA

Molecular weight: Translated: 37330; Mature: 37330

Theoretical pI: Translated: 3.99; Mature: 3.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGG
CCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLT
CCCHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
STTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
GGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLI
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
EKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDED
HCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
DWDEEDDW
CCCCCCCC
>Mature Secondary Structure
MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGG
CCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLT
CCCHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
STTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
GGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLI
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
EKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDED
HCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
DWDEEDDW
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036