Click here to switch to the map view.

The map label for this gene is eccCb1 [H]

Identifier: 148825079

GI number: 148825079

Start: 4361827

End: 4363602

Strand: Direct

Name: eccCb1 [H]

Synonym: TBFG_13906

Alternate gene names: 148825079

Gene position: 4361827-4363602 (Clockwise)

Preceding gene: 148825078

Following gene: 148825080

Centisome position: 98.58

GC content: 63.06

Gene sequence:

>1776_bases
ATGACTGCTGAACCGGAAGTACGGACGCTGCGCGAGGTTGTGCTGGACCAGCTCGGCACTGCTGAATCGCGTGCGTACAA
GATGTGGCTGCCGCCGTTGACCAATCCGGTCCCGCTCAACGAGCTCATCGCCCGTGATCGGCGACAACCCCTGCGATTTG
CCCTGGGGATCATGGATGAACCGCGCCGCCATCTACAGGATGTGTGGGGCGTAGACGTTTCCGGGGCCGGCGGCAACATC
GGTATTGGGGGCGCACCTCAAACCGGGAAGTCGACGCTACTGCAGACGATGGTGATGTCGGCCGCCGCCACACACTCACC
GCGCAACGTTCAGTTCTATTGCATCGACCTAGGTGGCGGCGGGCTGATCTATCTCGAAAACCTTCCACACGTCGGTGGGG
TAGCCAATCGGTCCGAGCCCGACAAGGTCAACCGGGTGGTCGCAGAGATGCAAGCCGTCATGCGGCAACGGGAAACCACC
TTCAAGGAACACCGAGTGGGCTCGATCGGGATGTACCGGCAGCTGCGTGACGATCCAAGTCAACCCGTTGCGTCCGATCC
ATACGGCGACGTCTTTCTGATCATCGACGGATGGCCCGGTTTTGTCGGCGAGTTCCCCGACCTTGAGGGGCAGGTTCAAG
ATCTGGCCGCCCAGGGGCTGGCGTTCGGCGTCCACGTCATCATCTCCACGCCACGCTGGACAGAGCTGAAGTCGCGTGTT
CGCGACTACCTCGGCACCAAGATCGAGTTCCGGCTTGGTGACGTCAATGAAACCCAGATCGACCGGATTACCCGCGAGAT
CCCGGCGAATCGTCCGGGTCGGGCAGTGTCGATGGAAAAGCACCATCTGATGATCGGCGTGTCCAGGTTCGACGGCGTGC
ACAGCGCCGATAACCTGGTGGAGGCGATCACCGCGGGGGTGACGCAGATCGCTTCCCAGCACACCGAACAGGCACCTCCG
GTGCGGGTCCTGCCGGAGCGTATCCACCTGCACGAACTCGACCCGAACCCGCCGGGACCAGAGTCCGACTACCGCACTCG
CTGGGAGATTCCGATCGGCTTGCGCGAGACGGACCTGACGCCGGCTCACTGCCACATGCACACGAACCCGCACCTACTGA
TCTTCGGTGCGGCCAAATCGGGCAAGACGACCATTGCCCACGCGATCGCGCGCGCCATTTGTGCCCGAAACAGTCCCCAG
CAGGTGCGGTTCATGCTCGCGGACTACCGCTCGGGCCTGCTGGACGCGGTGCCGGACACCCATCTGCTGGGCGCCGGCGC
GATCAACCGCAACAGCGCGTCGCTAGACGAGGCCGTTCAAGCACTGGCGGTCAACCTGAAGAAGCGGTTGCCGCCGACCG
ACCTGACGACGGCGCAGCTACGCTCGCGTTCGTGGTGGAGCGGATTTGACGTCGTGCTTCTGGTCGACGATTGGCACATG
ATCGTGGGTGCCGCCGGGGGGATGCCGCCGATGGCACCGCTGGCCCCGTTATTGCCGGCGGCGGCAGATATCGGGTTGCA
CATCATTGTCACCTGTCAGATGAGCCAGGCTTACAAGGCAACCATGGACAAGTTCGTCGGCGCCGCATTCGGGTCGGGCG
CTCCGACAATGTTCCTTTCCGGCGAGAAGCAGGAATTCCCATCCAGTGAGTTCAAGGTCAAGCGGCGCCCCCCTGGCCAG
GCATTTCTCGTCTCGCCAGACGGCAAAGAGGTCATCCAGGCCCCCTACATCGAGCCTCCAGAAGAAGTGTTCGCAGCACC
CCCAAGCGCCGGTTAA

Upstream 100 bases:

>100_bases
CGCGCCGGCGACGATGCAAAGCGCAGCGATGAGGAGGAGCGGCGCCAACGGCCCGCGCCGGCGACGATGCAAAGCGCAGC
GATGAGGAGGAGCGGCGCGC

Downstream 100 bases:

>100_bases
GATTATTTCATTGCCGGTGTAGCAGGACCCGAGCTCAGCCCGGTAATCGAGTTCGGGCAATGCTGACCATCGGGTTTGTT
TCCGGCTATAACCGAACGGT

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component Cb1; Type VII secretion system protein EccCb1; T7SS protein EccCb1 [H]

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNI
GIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETT
FKEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRV
RDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVSRFDGVHSADNLVEAITAGVTQIASQHTEQAPP
VRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQ
QVRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHM
IVGAAGGMPPMAPLAPLLPAAADIGLHIIVTCQMSQAYKATMDKFVGAAFGSGAPTMFLSGEKQEFPSSEFKVKRRPPGQ
AFLVSPDGKEVIQAPYIEPPEEVFAAPPSAG

Sequences:

>Translated_591_residues
MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNI
GIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETT
FKEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRV
RDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVSRFDGVHSADNLVEAITAGVTQIASQHTEQAPP
VRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQ
QVRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHM
IVGAAGGMPPMAPLAPLLPAAADIGLHIIVTCQMSQAYKATMDKFVGAAFGSGAPTMFLSGEKQEFPSSEFKVKRRPPGQ
AFLVSPDGKEVIQAPYIEPPEEVFAAPPSAG
>Mature_590_residues
TAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNIG
IGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETTF
KEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRVR
DYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVSRFDGVHSADNLVEAITAGVTQIASQHTEQAPPV
RVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQQ
VRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHMI
VGAAGGMPPMAPLAPLLPAAADIGLHIIVTCQMSQAYKATMDKFVGAAFGSGAPTMFLSGEKQEFPSSEFKVKRRPPGQA
FLVSPDGKEVIQAPYIEPPEEVFAAPPSAG

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). May link the cytosolic components of the system with the membrane components. Responsible for multiple suppressive effects on macrophages and req

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 FtsK domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR002543 [H]

Pfam domain/function: PF01580 FtsK_SpoIIIE [H]

EC number: NA

Molecular weight: Translated: 64552; Mature: 64420

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50901 FTSK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDE
CCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHCCCCC
PRRHLQDVWGVDVSGAGGNIGIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGG
HHHHHHHHHCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
GLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETTFKEHRVGSIGMYRQLRDDPS
CEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
QPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRV
CCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCCHHHHHHHH
RDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVSRFDGVHSADNLV
HHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCEEEEEEHHHCCCCCHHHHH
EAITAGVTQIASQHTEQAPPVRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLT
HHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCC
PAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQQVRFMLADYRSGLLDAVPDT
CHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCC
HLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHM
CEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEEECCEE
IVGAAGGMPPMAPLAPLLPAAADIGLHIIVTCQMSQAYKATMDKFVGAAFGSGAPTMFLS
EEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEC
GEKQEFPSSEFKVKRRPPGQAFLVSPDGKEVIQAPYIEPPEEVFAAPPSAG
CCHHHCCCCCCEEEECCCCCEEEECCCCHHHHCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
TAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDE
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHCCCCC
PRRHLQDVWGVDVSGAGGNIGIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGG
HHHHHHHHHCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
GLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETTFKEHRVGSIGMYRQLRDDPS
CEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
QPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRV
CCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCCHHHHHHHH
RDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVSRFDGVHSADNLV
HHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCEEEEEEHHHCCCCCHHHHH
EAITAGVTQIASQHTEQAPPVRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLT
HHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCC
PAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQQVRFMLADYRSGLLDAVPDT
CHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCC
HLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHM
CEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEEECCEE
IVGAAGGMPPMAPLAPLLPAAADIGLHIIVTCQMSQAYKATMDKFVGAAFGSGAPTMFLS
EEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEC
GEKQEFPSSEFKVKRRPPGQAFLVSPDGKEVIQAPYIEPPEEVFAAPPSAG
CCHHHCCCCCCEEEECCCCCEEEECCCCHHHHCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]