Click here to switch to the map view.

The map label for this gene is espA [H]

Identifier: 148824820

GI number: 148824820

Start: 4068200

End: 4069378

Strand: Reverse

Name: espA [H]

Synonym: TBFG_13647

Alternate gene names: 148824820

Gene position: 4069378-4068200 (Counterclockwise)

Preceding gene: 148824823

Following gene: 148824819

Centisome position: 91.98

GC content: 63.27

Gene sequence:

>1179_bases
ATGAGCAGAGCGTTCATCATCGATCCAACGATCAGTGCCATTGACGGCTTGTACGACCTTCTGGGGATTGGAATACCCAA
CCAAGGGGGTATCCTTTACTCCTCACTAGAGTACTTCGAAAAAGCCCTGGAGGAGCTGGCAGCAGCGTTTCCGGGTGATG
GCTGGTTAGGTTCGGCCGCGGACAAATACGCCGGCAAAAACCGCAACCACGTGAATTTTTTCCAGGAACTGGCAGACCTC
GATCGTCAGCTCATCAGCCTGATCCACGACCAGGCCAACGCGGTCCAGACGACCCGCGACATCCTGGAGGGCGCCAAGAA
AGGTCTCGAGTTCGTGCGCCCGGTGGCTGTGGACCTGACCTACATCCCGGTCGTCGGGCACGCCCTATCGGCCGCCTTCC
AGGCGCCGTTTTGCGCGGGCGCGATGGCCGTAGTGGGCGGCGCGCTTGCCTACTTGGTCGTGAAAACGCTGATCAACGCG
ACTCAACTCCTCAAATTGCTTGCCAAATTGGCGGAGTTGGTCGCGGCCGCCATTGCGGACATCATTTCGGATGTGGCGGA
CATCATCAAGGGCATCCTCGGAGAAGTGTGGGAGTTCATCACAAACGCGCTCAACGGCCTGAAAGAGCTTTGGGACAAGC
TCACGGGGTGGGTGACCGGACTGTTCTCTCGAGGGTGGTCGAACCTGGAGTCCTTCTTTGCGGGCGTCCCCGGCTTGACC
GGCGCGACCAGCGGCTTGTCGCAAGTGACTGGCTTGTTCGGTGCGGCCGGTCTGTCCGCATCGTCGGGCTTGGCTCACGC
GGATAGCCTGGCGAGCTCAGCCAGCTTGCCCGCCCTGGCCGGCATTGGGGGCGGGTCCGGTTTTGGGGGCTTGCCGAGCC
TGGCTCAGGTCCATGCCGCCTCAACTCGGCAGGCGCTACGGCCCCGAGCTGATGGCCCGGTCGGCGCCGCTGCCGAGCAG
GTCGGCGGGCAGTCGCAGCTGGTCTCCGCGCAGGGTTCCCAAGGTATGGGCGGACCCGTAGGCATGGGCGGCATGCACCC
CTCTTCGGGGGCGTCGAAAGGGACGACGACGAAGAAGTACTCGGAAGGCGCGGCGGCGGGCACTGAAGACGCCGAGCGCG
CGCCAGTCGAAGCTGACGCGGGCGGTGGGCAAAAGGTGCTGGTACGAAACGTCGTCTAA

Upstream 100 bases:

>100_bases
GACATCGGCCAAGCATGACAGCCAGACTGTAGGCCCTACGCGTGCAATGCAGAACCAAGGCTATGCATGGAATCGACGAC
CGTTGAGATAGGCGGCAGGC

Downstream 100 bases:

>100_bases
CGGCATGGCGAGCCAAATCCATTGCTAGCCAGCGCCTAACAACGCGCAATGCTAAACGGAAGGGACACGATCAATGACGG
AAAACTTGACCGTCCAGCCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSRAFIIDPTISAIDGLYDLLGIGIPNQGGILYSSLEYFEKALEELAAAFPGDGWLGSAADKYAGKNRNHVNFFQELADL
DRQLISLIHDQANAVQTTRDILEGAKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGALAYLVVKTLINA
TQLLKLLAKLAELVAAAIADIISDVADIIKGILGEVWEFITNALNGLKELWDKLTGWVTGLFSRGWSNLESFFAGVPGLT
GATSGLSQVTGLFGAAGLSASSGLAHADSLASSASLPALAGIGGGSGFGGLPSLAQVHAASTRQALRPRADGPVGAAAEQ
VGGQSQLVSAQGSQGMGGPVGMGGMHPSSGASKGTTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV

Sequences:

>Translated_392_residues
MSRAFIIDPTISAIDGLYDLLGIGIPNQGGILYSSLEYFEKALEELAAAFPGDGWLGSAADKYAGKNRNHVNFFQELADL
DRQLISLIHDQANAVQTTRDILEGAKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGALAYLVVKTLINA
TQLLKLLAKLAELVAAAIADIISDVADIIKGILGEVWEFITNALNGLKELWDKLTGWVTGLFSRGWSNLESFFAGVPGLT
GATSGLSQVTGLFGAAGLSASSGLAHADSLASSASLPALAGIGGGSGFGGLPSLAQVHAASTRQALRPRADGPVGAAAEQ
VGGQSQLVSAQGSQGMGGPVGMGGMHPSSGASKGTTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV
>Mature_391_residues
SRAFIIDPTISAIDGLYDLLGIGIPNQGGILYSSLEYFEKALEELAAAFPGDGWLGSAADKYAGKNRNHVNFFQELADLD
RQLISLIHDQANAVQTTRDILEGAKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGALAYLVVKTLINAT
QLLKLLAKLAELVAAAIADIISDVADIIKGILGEVWEFITNALNGLKELWDKLTGWVTGLFSRGWSNLESFFAGVPGLTG
ATSGLSQVTGLFGAAGLSASSGLAHADSLASSASLPALAGIGGGSGFGGLPSLAQVHAASTRQALRPRADGPVGAAAEQV
GGQSQLVSAQGSQGMGGPVGMGGMHPSSGASKGTTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV

Specific function: Required for virulence. Required for secretion of EsxA (ESAT-6) and EsxB (CFP-10) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Probably secreted via the ESX-1 / type VII secretion system (T7SS) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 39901; Mature: 39769

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCHHHCCCCCCCCCCCEEHHCCCC
>Mature Secondary Structure 
SRAFIIDPTISAIDGLYDLLGIGIPNQGGILYSSLEYFEKALEELAAAFPGDGWLGSAA
CCCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH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CCCCCCCCCCHHHCCCCCCCCCCCEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]