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The map label for this gene is celR [H]

Identifier: 148824781

GI number: 148824781

Start: 4029870

End: 4031084

Strand: Reverse

Name: celR [H]

Synonym: TBFG_13608

Alternate gene names: 148824781

Gene position: 4031084-4029870 (Counterclockwise)

Preceding gene: 148824785

Following gene: 148824780

Centisome position: 91.11

GC content: 66.91

Gene sequence:

>1215_bases
GTGCCTGGGCATCCAGCAAAACGGGGAGCTCAAGAACGATTCATGAACGAGGGGTCGTCACCAACGTCGAAACCGACGGT
TGCCAGCCGGCCCACGATATTGCGTGCTCGAGGGTCCGCTGTACCCTCACCGAACGTGAGTCCCACACCGCGGAGGCGGG
CGACTCTGGCGTCGTTAGCAGCCGAGCTCAAGGTGTCCCGCACCACTGTCTCGAATGCTTTTAACCGACCGGATCAGCTC
TCCGCCGATCTACGTGAACGAGTGCTTGCCACGGCCAAGCGACTGGGCTATGCCGGACCGGATCCGGTGGCGCGATCGTT
GCGGACCCGCAAAGCCGGTGCGGTCGGTTTGGTGATGGCCGAACCGCTGACCTATTTCTTCAGCGACCCGGCCGCGCGGG
ATTTTGTTGCGGGAGTGGCGCAGTCGTGCGAAGAGCTGGGGCAGGGCCTGCAGCTGGTTTCCGTCGGCTCCAGTCGGAGC
CTTGCGGACGGCACAGCTGCCGTGCTCGGCGCTGGGGTGGACGGCTTCGTGGTGTATTCGGTAGGCGACGACGATCCCTA
CCTGCAGGTCGTGCTGCAGCGGCGGCTGCCGGTGGTGGTGGTCGACCAGCCCAAAGACCTCTCCGGAGTGTCCCGGGTCG
GCATCGACGACCGGGCGGCGATGCGTGAGCTTGCCGGCTACGTACTCGGGTTGGGGCATCGCGAGCTCGGCCTGCTGACC
ATGCGGCTGGGACGGGATCGGCGGCAAGACTTGGTGGACGCCGAGCGGCTGCGGTCGCCGACCTTCGACGTACAGCGCGA
ACGCATCGTCGGCGTATGGGAGGCGATGACGGCCGCCGGCGTCGACCCGGACTCGCTGACCGTGGTGGAAAGCTACGAGC
ATTTGCCGACGTCCGGCGGCACTGCCGCCAAGGTGGCTCTGCAGGCCAATCCGCGGCTGACCGCGCTGATGTGCACAGCG
GACATCTTGGCGCTCTCAGCTATGGATTACCTTCGGGCGCACGGGATTTACGTGCCCGGGCAGATGACCGTCACAGGGTT
TGACGGAGTGCCAGAGGCGCTGAGCCGGGGGCTGACCACGGTCGCGCAGCCGAGTCTGCACAAGGGGCACCGGGCGGGCG
AGCTATTGCTGAAGCCGCCGCGGTCCGGACTGCCCGTCATCGAGGTGCTCGATACCGAGCTGGTCCGGGGCCGCACCGCG
GGTCCGCCGGCGTAA

Upstream 100 bases:

>100_bases
TGCACGCACCGACCAGCGCGGCGAGCGCGGCTAGCTGCTTGCCCACTGTTCCTCCCTGCCGGCACCATGTGCGACAAGCT
TAAGCGCAGCAGTACCGGCG

Downstream 100 bases:

>100_bases
GTCTTCTAGGCGCTGTCTTGATCGCCGATCAGCAGCCGCACGGCCAGGTCCAGCCGCTTGCTGACGTCGGTAGCCGAGGC
TCGTCGGGTAAGCCACGCGA

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MPGHPAKRGAQERFMNEGSSPTSKPTVASRPTILRARGSAVPSPNVSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQL
SADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRS
LADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLT
MRLGRDRRQDLVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTA
DILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTTVAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVRGRTA
GPPA

Sequences:

>Translated_404_residues
MPGHPAKRGAQERFMNEGSSPTSKPTVASRPTILRARGSAVPSPNVSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQL
SADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRS
LADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLT
MRLGRDRRQDLVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTA
DILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTTVAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVRGRTA
GPPA
>Mature_403_residues
PGHPAKRGAQERFMNEGSSPTSKPTVASRPTILRARGSAVPSPNVSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLS
ADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRSL
ADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLTM
RLGRDRRQDLVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTAD
ILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTTVAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVRGRTAG
PPA

Specific function: Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA- 3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=330, Percent_Identity=27.5757575757576, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790369, Length=365, Percent_Identity=26.027397260274, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790194, Length=334, Percent_Identity=27.2455089820359, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI48994940, Length=330, Percent_Identity=24.8484848484848, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789068, Length=303, Percent_Identity=23.7623762376238, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 42891; Mature: 42759

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGHPAKRGAQERFMNEGSSPTSKPTVASRPTILRARGSAVPSPNVSPTPRRRATLASLA
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHH
AELKVSRTTVSNAFNRPDQLSADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEHH
EPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYS
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCCCEEEEE
VGDDDPYLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLT
ECCCCHHHHHHHHHCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHH
MRLGRDRRQDLVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGG
HHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHCCCCCC
TAAKVALQANPRLTALMCTADILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTT
CEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCEECCCEEEEECCCCCHHHHHCCCHH
VAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVRGRTAGPPA
HCCCCHHCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PGHPAKRGAQERFMNEGSSPTSKPTVASRPTILRARGSAVPSPNVSPTPRRRATLASLA
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHH
AELKVSRTTVSNAFNRPDQLSADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEHH
EPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYS
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCCCEEEEE
VGDDDPYLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLT
ECCCCHHHHHHHHHCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHH
MRLGRDRRQDLVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGG
HHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHCCCCCC
TAAKVALQANPRLTALMCTADILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTT
CEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCEECCCEEEEECCCCCHHHHHCCCHH
VAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVRGRTAGPPA
HCCCCHHCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10224066 [H]