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The map label for this gene is eccD4

Identifier: 148824658

GI number: 148824658

Start: 3882063

End: 3883466

Strand: Direct

Name: eccD4

Synonym: TBFG_13485

Alternate gene names: 148824658

Gene position: 3882063-3883466 (Clockwise)

Preceding gene: 148824648

Following gene: 148824659

Centisome position: 87.74

GC content: 67.45

Gene sequence:

>1404_bases
ATGCCTACGTCTGATCCGGGACTGCGCCGGGTCACCGTACATGCCGGCGCCCAGGCCGTCGACCTGACCTTGCCCGCCGC
GGTGCCCGTCGCGACTCTGATCCCGTCGATCGTCGACATCCTGGGTGACCGTGGCGCCAGCCCGGCGACGGCGGCGCGCT
ACCAGCTGTCTGCCCTGGGGGCGCCAGCTCTGCCAAACGCAACGACATTGGCGCAATGCGGTATCCGCGACGGCGCCGTC
CTGGTCTTGCATAAGTCCAGCGCCCAGCCGCCCACCCCCCGCTGTGACGATGTGGCCGAAGCGGTGGCGGCGGCGCTTGA
CACCACAGCCCGGCCCCAATGCCAGCGCACGACCCGGCTCAGCGGTGCGCTGGCGGCAAGCTGCATCACCGCCGGCGGCG
GCCTGATGCTGGTTCGAAACGCCCTCGGCACCAACGTAACCCGCTACTCCGACGCCACGGCCGGAGTTGTAGCGGCGGCC
GGCTTGGCTGCCTTGCTGTTTGCGGTGATTGCATGCCGGACATATCGGGACCCGATCGCCGGCCTCACGTTGAGCGTTAT
CGCCACCATATTCGGTGCTGTTGCCGGCCTACTGGCGGTGCCCGGGGTCCCCGGTGTCCATAGCGTGCTAGTTGCCGCGA
TGGCGGCGGCCGCCACGTCGGTGCTGGCAATGCGCATAACGGGTTGTGGGGGTATCACGTTGACCGCGGTGGCGTGCTGC
GCGGTAGTCGTCGCGGCCGCTACGCTGGTCGGCGCGATCACTGCGGCCCCGGTGCCTGCCATCGGTTCGCTGGCCACGCT
GGCATCCTTTGGTCTGTTAGAGGTATCCGCGCGGATGGCAGTCCTGTTGGCGGGGTTGTCGCCACGATTGCCGCCCGCGC
TGAACCCCGACGACGCCGATGCCCTGCCCACCACGGATCGGCTGACCACCCGAGCGAACCGTGCAGATGCTTGGTTGACG
AGCCTGCTGGCGGCCTTCGCGGCCTCGGCGACCATCGGTGCCATCGGAACCGCCGTCGCAACCCACGGCATCCACAGGTC
CAGCATGGGCGGTATCGCGTTGGCCGCCGTCACCGGTGCGCTGCTGCTGCTACGAGCACGTTCAGCAGACACCAGAAGGT
CACTGGTGTTTGCCATCTGTGGAATCACCACCGTTGCAACGGCATTTACCGTCGCCGCGGATCGGGCTCTGGAACACGGG
CCGTGGATTGCCGCGCTGACCGCCATGCTGGCCGCCGTGGCAATGTTTTTGGGCTTCGTCGCTCCCGCGTTGTCGCTCTC
GCCCGTCACGTACCGCACCATCGAATTGCTGGAGTGTCTGGCGCTGATCGCAATGGTTCCATTGACCGCTTGGCTATGCG
GCGCCTACAGCGCCGTTCGCCACCTCGACCTGACATGGACATGA

Upstream 100 bases:

>100_bases
ATGCAGCGCGAGAATCCGCCGCAAGTCGCTTGTGGACAACCGAATACCGGGCGATCGAGAACCGGCTACCGTTCCGGTGA
TCCGAGAATAAAGGGGGAGA

Downstream 100 bases:

>100_bases
CCACGTCCCGTACCCTGCGCCTGCTGGTGGTATCAGCGCTCGCGACGCTGTCTGGGTTGGGAACGCCGGTTGCCCACGCG
GTTTCGCCGCCGCCGATCGA

Product: integral membrane protein

Products: NA

Alternate protein names: ESX conserved component D4; Type VII secretion system protein eccD4; T7SS protein eccD4

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRGASPATAARYQLSALGAPALPNATTLAQCGIRDGAV
LVLHKSSAQPPTPRCDDVAEAVAAALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAA
GLAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVLAMRITGCGGITLTAVACC
AVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMAVLLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLT
SLLAAFAASATIGAIGTAVATHGIHRSSMGGIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEHG
PWIAALTAMLAAVAMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT

Sequences:

>Translated_467_residues
MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRGASPATAARYQLSALGAPALPNATTLAQCGIRDGAV
LVLHKSSAQPPTPRCDDVAEAVAAALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAA
GLAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVLAMRITGCGGITLTAVACC
AVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMAVLLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLT
SLLAAFAASATIGAIGTAVATHGIHRSSMGGIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEHG
PWIAALTAMLAAVAMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT
>Mature_466_residues
PTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRGASPATAARYQLSALGAPALPNATTLAQCGIRDGAVL
VLHKSSAQPPTPRCDDVAEAVAAALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAG
LAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVLAMRITGCGGITLTAVACCA
VVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMAVLLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLTS
LLAAFAASATIGAIGTAVATHGIHRSSMGGIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEHGP
WIAALTAMLAAVAMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eccD/snm4 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCD4_MYCTU (O33354)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842583
- PIR:   E70564
- RefSeq:   NP_217965.1
- RefSeq:   NP_338080.1
- ProteinModelPortal:   O33354
- EnsemblBacteria:   EBMYCT00000003202
- EnsemblBacteria:   EBMYCT00000069492
- GeneID:   887624
- GeneID:   922977
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3554
- KEGG:   mtu:Rv3448
- TIGR:   MT3554
- TubercuList:   Rv3448
- GeneTree:   EBGT00050000016341
- HOGENOM:   HBG580538
- OMA:   PARWELA
- ProtClustDB:   CLSK792501
- InterPro:   IPR006707
- TIGRFAMs:   TIGR02958

Pfam domain/function: PF04600 DUF571

EC number: NA

Molecular weight: Translated: 46731; Mature: 46600

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1e42bcd8)-; HASH(0x1cb7527c)-; HASH(0x1ca3962c)-; HASH(0x1745692c)-; HASH(0x1df824a8)-; HASH(0x1dfb5efc)-; HASH(0x1d613b5c)-; HASH(0x1d4dd684)-; HASH(0x1dc4ad18)-; HASH(0x1a55e6b8)-; HASH(0x1e42e404)-;

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRGASPATAARYQLSALG
CCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
APALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAAALDTTARPQCQRTTRL
CCCCCCCHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
SGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAGLAALLFAVIACRTYRDPIA
HHHHHHHHHHCCCCHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
GLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVLAMRITGCGGITLTAVACC
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMAVLLAGLSPRLPPALNPDDAD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ALPTTDRLTTRANRADAWLTSLLAAFAASATIGAIGTAVATHGIHRSSMGGIALAAVTGA
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEHGPWIAALTAMLAAVAMFLGFV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
APALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure 
PTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRGASPATAARYQLSALG
CCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
APALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAAALDTTARPQCQRTTRL
CCCCCCCHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
SGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAGLAALLFAVIACRTYRDPIA
HHHHHHHHHHCCCCHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
GLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVLAMRITGCGGITLTAVACC
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMAVLLAGLSPRLPPALNPDDAD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ALPTTDRLTTRANRADAWLTSLLAAFAASATIGAIGTAVATHGIHRSSMGGIALAAVTGA
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEHGPWIAALTAMLAAVAMFLGFV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
APALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036