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The map label for this gene is gcp

Identifier: 148824626

GI number: 148824626

Start: 3848847

End: 3849881

Strand: Reverse

Name: gcp

Synonym: TBFG_13453

Alternate gene names: 148824626

Gene position: 3849881-3848847 (Counterclockwise)

Preceding gene: 148824627

Following gene: 148824625

Centisome position: 87.01

GC content: 68.89

Gene sequence:

>1035_bases
ATGACGACAGTCTTGGGCATCGAAACCTCCTGCGATGAAACCGGTGTCGGCATCGCGCGGCTCGATCCCGATGGCACCGT
GACATTGTTGGCCGACGAGGTGGCTTCCAGTGTCGACGAGCATGTTCGGTTCGGCGGCGTGGTCCCCGAGATTGCCTCCC
GTGCGCACCTGGAGGCACTGGGTCCCGCGATGCGCCGCGCGCTGGCGGCCGCCGGCTTGAAACAGCCAGACATTGTCGCG
GCCACCATCGGTCCCGGGCTCGCGGGCGCCCTGTTGGTGGGAGTGGCTGCGGCCAAGGCATATTCGGCTGCTTGGGGGGT
GCCGTTCTATGCGGTGAATCATCTGGGCGGGCACTTGGCCGCCGACGTCTACGAACACGGGCCGCTGCCCGAGTGTGTGG
CGTTGTTGGTGTCCGGAGGACATACCCACCTGTTGCACGTTCGCTCGCTCGGTGAGCCGATCATCGAGCTGGGCAGCACC
GTCGACGACGCCGCCGGCGAGGCCTACGACAAGGTGGCCCGGTTGCTGGGATTGGGCTATCCGGGTGGCAAGGCGCTCGA
CGACCTGGCGCGCACCGGTGATCGGGACGCCATCGTTTTCCCGCGCGGCATGAGTGGCCCGGCCGATGACCGCTATGCGT
TCAGCTTCTCCGGGCTCAAGACGGCCGTCGCGCGGTATGTGGAAAGCCACGCGGCTGACCCGGGCTTCCGTACCGCCGAC
ATTGCCGCCGGATTCCAGGAGGCCGTCGCGGACGTGTTGACCATGAAGGCGGTACGGGCCGCCACTGCGCTAGGCGTCTC
AACGCTGCTGATCGCGGGGGGAGTGGCGGCGAACTCCCGGCTGCGAGAGCTGGCCACACAGCGCTGCGGCGAGGCGGGCC
GGACGTTGCGGATCCCCAGTCCCCGGCTATGCACCGACAACGGGGCGATGATCGCGGCGTTCGCCGCGCAGCTGGTGGCC
GCGGGAGCGCCGCCGTCGCCGCTGGACGTGCCCAGTGACCCGGGTCTGCCCGTGATGCAGGGGCAGGTGCGGTGA

Upstream 100 bases:

>100_bases
ATCGCAGCGTGGGATTCCAGCGGGTCGGCTTGCGCCGGCGATATTACCGGGTCAGCGGCGCCGACGCGTACACGATGCGT
AGGGATTCGGGGGACCCGTC

Downstream 100 bases:

>100_bases
CCCGGACATTGCACCTGGCGTACCCGGACACGCTGGCAACCAGGAAGCAAGGGGGCGCCCTTGAGTGCTAGCACTCTCAT
GTATAGAGTGCTAGATGGCA

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEALGPAMRRALAAAGLKQPDIVA
ATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGST
VDDAAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARYVESHAADPGFRTAD
IAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPSPRLCTDNGAMIAAFAAQLVA
AGAPPSPLDVPSDPGLPVMQGQVR

Sequences:

>Translated_344_residues
MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEALGPAMRRALAAAGLKQPDIVA
ATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGST
VDDAAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARYVESHAADPGFRTAD
IAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPSPRLCTDNGAMIAAFAAQLVA
AGAPPSPLDVPSDPGLPVMQGQVR
>Mature_343_residues
TTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEALGPAMRRALAAAGLKQPDIVAA
TIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGSTV
DDAAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARYVESHAADPGFRTADI
AAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPSPRLCTDNGAMIAAFAAQLVAA
GAPPSPLDVPSDPGLPVMQGQVR

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=346, Percent_Identity=33.2369942196532, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI8923380, Length=327, Percent_Identity=32.1100917431193, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1789445, Length=347, Percent_Identity=46.3976945244957, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71995670, Length=333, Percent_Identity=31.8318318318318, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557464, Length=329, Percent_Identity=30.3951367781155, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320099, Length=358, Percent_Identity=29.3296089385475, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322891, Length=336, Percent_Identity=27.9761904761905, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI20129063, Length=350, Percent_Identity=33.4285714285714, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21357207, Length=343, Percent_Identity=31.7784256559767, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_MYCBO (P65802)

Other databases:

- EMBL:   BX248346
- RefSeq:   NP_857093.1
- ProteinModelPortal:   P65802
- SMR:   P65802
- MEROPS:   M22.001
- EnsemblBacteria:   EBMYCT00000017365
- GeneID:   1091033
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3453c
- GeneTree:   EBGT00050000017447
- HOGENOM:   HBG304663
- OMA:   PLYGVNH
- ProtClustDB:   PRK09604
- BioCyc:   MBOV233413:MB3453C-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 35091; Mature: 34960

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEAL
CCEEEECCCCCCCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GPAMRRALAAAGLKQPDIVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLA
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHH
ADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGSTVDDAAGEAYDKVARLLGLGY
HHHHHCCCHHHHHHHHHCCCCCEEEEHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
PGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARYVESHAADPGFRTAD
CCCHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHH
IAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEECCC
PRLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDPGLPVMQGQVR
CCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEAL
CEEEECCCCCCCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GPAMRRALAAAGLKQPDIVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLA
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHH
ADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGSTVDDAAGEAYDKVARLLGLGY
HHHHHCCCHHHHHHHHHCCCCCEEEEHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
PGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARYVESHAADPGFRTAD
CCCHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHH
IAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEECCC
PRLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDPGLPVMQGQVR
CCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972