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The map label for this gene is drrC

Identifier: 148824127

GI number: 148824127

Start: 3285545

End: 3286375

Strand: Direct

Name: drrC

Synonym: TBFG_12952

Alternate gene names: 148824127

Gene position: 3285545-3286375 (Clockwise)

Preceding gene: 148824126

Following gene: 148824128

Centisome position: 74.26

GC content: 57.52

Gene sequence:

>831_bases
ATGATCACGACGACAAGTCAGGAAATCGAGCTTGCACCCACACGTTTGCCAGGCTCGCAAAACGCTGCTCGGCTGTTCGT
TGCGCAGACCCTTTTGCAGACCAACCGGTTGCTAACTCGATGGGCACGTGACTATATCACCGTTATCGGAGCGATCGTGT
TACCGATTCTCTTCATGGTGGTGTTGAACATTGTGCTAGGTAACCTAGCTTATGTCGTAACCCACGACAGCGGGCTCTAC
AGCATTGTTCCGCTGATCGCACTCGGCGCCGCGATCACTGGGTCAACTTTTGTCGCGATCGACCTGATGCGCGAGCGCTC
CTTCGGACTGCTTGCCCGACTGTGGGTGCTGCCCGTGCACCGAGCATCGGGCCTGATCTCTCGAATCCTGGCAAACGCGA
TTCGGACTCTGGTCACCACTTTAGTGATGCTAGGTACTGGGGTGGTATTGGGTTTCCGGTTTCGACAAGGCCTGATCCCG
AGCCTCATGTGGATTAGTGTCCCGGTGATACTGGGCATCGCAATCGCGGCTATGGTCACTACCGTCGCGCTTTACACAGC
ACAAACCGTTGTTGTCGAAGGCGTTGAGCTGGTGCAAGCAATCGCGATCTTCTTCTCCACGGGTTTGGTGCCGCTCAACT
CGTATCCAGGCTGGATTCAGCCGTTCGTCGCCCATCAGCCGGTGAGCTACGCCATCGCGGCGATGCGCGGTTTTGCAATG
GGTGGTCCGGTCCTCTCTCCGATGATCGGGATGCTGGTGTGGACCGCGGGTATCTGCGTCGTATGCGCCGTACCCTTGGC
CATTGGCTACCGACGGGCCAGCACGCATTGA

Upstream 100 bases:

>100_bases
CACAGGTGAGTTGGCCTGTGATGGCTCCGACGTTGACGTGGTTGTTCGCTTTCGTGGTGATCCTGGCGCTTTCATCCACC
ATTGTTTTGGCTAGGCGGCC

Downstream 100 bases:

>100_bases
CCAGCACCGCTGGCCCGGGATGCCGTGACGAGTTGGGAGTGTTGAGATGTTTCCCGGATCTGTGATCCGAAAGCTGTCGC
ACAGCGAGGAAGTCTTCGCG

Product: daunorubicin-dim-transport integral membrane protein ABC transporter drrC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTHDSGLY
SIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIP
SLMWISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPFVAHQPVSYAIAAMRGFAM
GGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH

Sequences:

>Translated_276_residues
MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTHDSGLY
SIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIP
SLMWISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPFVAHQPVSYAIAAMRGFAM
GGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH
>Mature_276_residues
MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTHDSGLY
SIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIP
SLMWISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPFVAHQPVSYAIAAMRGFAM
GGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH

Specific function: Probably part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DRRC_MYCTU (P96207)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842581
- PIR:   F70984
- RefSeq:   NP_217454.1
- RefSeq:   NP_337521.1
- ProteinModelPortal:   P96207
- EnsemblBacteria:   EBMYCT00000001274
- EnsemblBacteria:   EBMYCT00000071202
- GeneID:   888491
- GeneID:   925267
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3008
- KEGG:   mtu:Rv2938
- TIGR:   MT3008
- TubercuList:   Rv2938
- GeneTree:   EBGT00050000017453
- HOGENOM:   HBG564698
- OMA:   WLQPFVE
- ProtClustDB:   CLSK792176
- InterPro:   IPR000412
- InterPro:   IPR013525
- InterPro:   IPR004377
- InterPro:   IPR005943
- TIGRFAMs:   TIGR01248
- TIGRFAMs:   TIGR00025

Pfam domain/function: PF01061 ABC2_membrane

EC number: NA

Molecular weight: Translated: 29594; Mature: 29594

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c2865b0)-; HASH(0x1cf5bad0)-; HASH(0x1cb1b560)-; HASH(0x1cc7db24)-; HASH(0x1c787720)-; HASH(0x1b85a8a4)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMV
CCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLNIVLGNLAYVVTHDSGLYSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVH
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAMVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPFVAHQPVSYAIAAMRGFAM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHC
GGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMV
CCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLNIVLGNLAYVVTHDSGLYSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVH
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAMVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPFVAHQPVSYAIAAMRGFAM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHC
GGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036