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The map label for this gene is drrB

Identifier: 148824126

GI number: 148824126

Start: 3284679

End: 3285548

Strand: Direct

Name: drrB

Synonym: TBFG_12951

Alternate gene names: 148824126

Gene position: 3284679-3285548 (Clockwise)

Preceding gene: 148824125

Following gene: 148824127

Centisome position: 74.24

GC content: 59.43

Gene sequence:

>870_bases
ATGAGCGGCCCGGCCATAGATGCGAGCCCCGCCCTGACCTTCAACCAGTCAAGCGCGAGCATTCAGCAGCGACGCTTATC
GACCGGGCGACAGATGTGGGTGCTCTATCGGCGTTTCGCCGCGCCGAGCCTACTCAACGGTGAAGTACTCACCACGGTGG
GCGCGCCGATAATTTTCATGGTGGGCTTCTATATCCCGTTCGCCATACCGTGGAACCAATTTGTGGGTGGCGCCAGCTCG
GGCGTCGCCAGCAACTTAGGGCAATACATCACGCCGTTGGTCACACTGCAGGCGGTCTCGTTCGCCGCGATCGGGTCGGG
CTTTCGAGCCGCGACCGATTCGCTGCTAGGCGTCAATCGTCGGTTTCAGTCCATGCCGATGGCCCCGTTGACGCCACTGC
TTGCCCGCGTGTGGGTGGCTGTGGACCGATGCTTCACGGGTTTGGTGATATCGCTAGTTTGCGGCTACGTCATCGGATTC
CGTTTTCATCGCGGGGCCCTCTATATCGTCGGTTTTTGCCTACTGGTTATCGCGATCGGGGCTGTGCTGTCATTCGCCGC
TGACCTGGTTGGCACCGTTACCAGGAACCCAGACGCGATGCTGCCGCTGCTGAGCTTGCCCATTTTGATCTTCGGACTGC
TGTCCATTGGTCTCATGCCGTTAAAGCTGTTTCCGCACTGGATCCATCCATTTGTTCGCAACCAGCCGATCTCCCAGTTC
GTCGCGGCGCTGCGGGCATTGGCCGGAGATACCACCAAGACAGCCTCACAGGTGAGTTGGCCTGTGATGGCTCCGACGTT
GACGTGGTTGTTCGCTTTCGTGGTGATCCTGGCGCTTTCATCCACCATTGTTTTGGCTAGGCGGCCATGA

Upstream 100 bases:

>100_bases
CCGATATTGCGCTGCGCCGACCGTCACTCGATCACGTATTCCTGGCCATGACGACCGATCCCACCGAGTCTCTGACCCAT
CTGGTGTCGGGGTCAGCGCG

Downstream 100 bases:

>100_bases
TCACGACGACAAGTCAGGAAATCGAGCTTGCACCCACACGTTTGCCAGGCTCGCAAAACGCTGCTCGGCTGTTCGTTGCG
CAGACCCTTTTGCAGACCAA

Product: daunorubicin-dim-transport integral membrane protein ABC transporter drrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASS
GVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGF
RFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQF
VAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP

Sequences:

>Translated_289_residues
MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASS
GVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGF
RFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQF
VAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP
>Mature_288_residues
SGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSG
VASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGFR
FHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFV
AALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP

Specific function: Part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DRRB_MYCTU (P96206)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842581
- PIR:   E70984
- RefSeq:   NP_217453.1
- RefSeq:   NP_337520.1
- ProteinModelPortal:   P96206
- EnsemblBacteria:   EBMYCT00000001224
- EnsemblBacteria:   EBMYCT00000071055
- GeneID:   887968
- GeneID:   925269
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3007
- KEGG:   mtu:Rv2937
- TIGR:   MT3007
- TubercuList:   Rv2937
- GeneTree:   EBGT00050000017453
- HOGENOM:   HBG322644
- OMA:   RNGELAT
- ProtClustDB:   CLSK792175
- InterPro:   IPR004377
- TIGRFAMs:   TIGR00025

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 31109; Mature: 30978

Theoretical pI: Translated: 11.50; Mature: 11.50

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c106efc)-; HASH(0x1c194f78)-; HASH(0x1ced2ef4)-; HASH(0x1cd2fa28)-; HASH(0x197eec18)-; HASH(0x1cc5bad8)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECH
>Mature Secondary Structure 
SGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFM
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
VGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNR
HHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
AVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP
HHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036