| Definition | Mycobacterium tuberculosis F11, complete genome. |
|---|---|
| Accession | NC_009565 |
| Length | 4,424,435 |
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The map label for this gene is fabG [C]
Identifier: 148823938
GI number: 148823938
Start: 3074771
End: 3075589
Strand: Direct
Name: fabG [C]
Synonym: TBFG_12763
Alternate gene names: 148823938
Gene position: 3074771-3075589 (Clockwise)
Preceding gene: 148823936
Following gene: 148823939
Centisome position: 69.5
GC content: 65.81
Gene sequence:
>819_bases GTGATCGACCGGCCACTCGAAGGCAAGGTCGCCTTCATCACCGGCGCCGCGCGCGGCTTGGGCCGCGCACACGCGGTTCG ACTGGCAGCCGACGGCGCGAACATCATCGCGGTTGACATCTGCGAGCAGATCGCCAGCGTGCCTTATCCGTTGAGCACCG CCGACGACCTGGCGGCCACCGTCGAGCTCGTCGAGGACGCCGGCGGCGGGATCGTGGCCAGACAGGGCGACGTTCGCGAT CGCGCATCACTGTCGGTCGCATTGCAGGCGGGCCTTGACGAGTTCGGCCGGCTCGACATCGTGGTGGCCAATGCCGGTAT CGCGATGATGCAGGCCGGCGACGACGGCTGGCGCGACGTTATCGACGTCAACCTCACCGGCGTCTTCCACACCGTACAGG TGGCGATCCCGACCCTGATCGAGCAGGGCACCGGTGGGTCGATCGTGTTGATCAGCTCGGCCGCGGGACTGGTCGGCATC GGCAGCAGTGATCCCGGATCGCTTGGCTACGCGGCCGCCAAGCACGGCGTCGTCGGCCTGATGAGGGCGTACGCGAACCA TCTGGCACCGCAAAACATTCGGGTTAACTCGGTACATCCTTGCGGGGTCGATACGCCGATGATCAACAATGAGTTCTTCC AGCAGTGGCTAACCACTGCTGACATGGACGCGCCGCACAACCTGGGTAACGCGCTGCCCGTCGAGCTGGTGCAGCCAACC GACATCGCCAACGCGGTGGCATGGCTGGCGTCCGAGGAGGCGCGCTATGTCACCGGCGTCACCTTGCCGGTCGACGCGGG CTTTGTGAACAAGAGGTAG
Upstream 100 bases:
>100_bases CCATGTTTACCGCGGCCGGCGAGCACCTGGTCGGGGCGCCGGACATCAAACTGCTGCAGCCGGTTCCCGCCGGCGACCCG AGCAAAGGGCAGCTGCGCCG
Downstream 100 bases:
>100_bases CTGATGGCTCGAAATCCCGCTGCGCAGACCGCCTTCGGCCCGATGGTGTTGGCGGCCGTGGAGCAAAACGAACCACCTGG CCGCCGCCTGGTGGACGACG
Product: 3-ketoacyl-(acyl-carrier-protein) reductase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 272; Mature: 272
Protein sequence:
>272_residues MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASVPYPLSTADDLAATVELVEDAGGGIVARQGDVRD RASLSVALQAGLDEFGRLDIVVANAGIAMMQAGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGI GSSDPGSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLTTADMDAPHNLGNALPVELVQPT DIANAVAWLASEEARYVTGVTLPVDAGFVNKR
Sequences:
>Translated_272_residues MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASVPYPLSTADDLAATVELVEDAGGGIVARQGDVRD RASLSVALQAGLDEFGRLDIVVANAGIAMMQAGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGI GSSDPGSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLTTADMDAPHNLGNALPVELVQPT DIANAVAWLASEEARYVTGVTLPVDAGFVNKR >Mature_272_residues MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASVPYPLSTADDLAATVELVEDAGGGIVARQGDVRD RASLSVALQAGLDEFGRLDIVVANAGIAMMQAGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGI GSSDPGSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLTTADMDAPHNLGNALPVELVQPT DIANAVAWLASEEARYVTGVTLPVDAGFVNKR
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=278, Percent_Identity=34.1726618705036, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI32483357, Length=270, Percent_Identity=30.3703703703704, Blast_Score=105, Evalue=5e-23, Organism=Homo sapiens, GI4504505, Length=270, Percent_Identity=31.1111111111111, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI19923817, Length=270, Percent_Identity=27.4074074074074, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI31542939, Length=208, Percent_Identity=32.6923076923077, Blast_Score=88, Evalue=1e-17, Organism=Homo sapiens, GI126723750, Length=270, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI126723191, Length=200, Percent_Identity=32, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI40254992, Length=265, Percent_Identity=30.5660377358491, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI7705925, Length=270, Percent_Identity=28.1481481481481, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI10190704, Length=273, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI4758504, Length=222, Percent_Identity=30.1801801801802, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI5031737, Length=279, Percent_Identity=27.5985663082437, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI7706318, Length=209, Percent_Identity=26.7942583732057, Blast_Score=72, Evalue=7e-13, Organism=Homo sapiens, GI223718074, Length=203, Percent_Identity=29.5566502463054, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI59889578, Length=202, Percent_Identity=29.7029702970297, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI66933014, Length=267, Percent_Identity=26.5917602996255, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI40254986, Length=203, Percent_Identity=29.5566502463054, Blast_Score=67, Evalue=1e-11, Organism=Escherichia coli, GI1787335, Length=267, Percent_Identity=35.9550561797753, Blast_Score=124, Evalue=7e-30, Organism=Escherichia coli, GI87082100, Length=274, Percent_Identity=33.5766423357664, Blast_Score=120, Evalue=9e-29, Organism=Escherichia coli, GI1789208, Length=271, Percent_Identity=32.4723247232472, Blast_Score=112, Evalue=2e-26, Organism=Escherichia coli, GI1788459, Length=269, Percent_Identity=31.5985130111524, Blast_Score=97, Evalue=1e-21, Organism=Escherichia coli, GI87082160, Length=269, Percent_Identity=30.8550185873606, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1787905, Length=273, Percent_Identity=29.6703296703297, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1790717, Length=272, Percent_Identity=29.7794117647059, Blast_Score=82, Evalue=3e-17, Organism=Escherichia coli, GI2367175, Length=267, Percent_Identity=29.9625468164794, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI1786812, Length=272, Percent_Identity=27.5735294117647, Blast_Score=76, Evalue=3e-15, Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=27.7992277992278, Blast_Score=75, Evalue=6e-15, Organism=Escherichia coli, GI1788891, Length=275, Percent_Identity=29.0909090909091, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1789057, Length=271, Percent_Identity=30.2583025830258, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1787526, Length=279, Percent_Identity=26.8817204301075, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI2367365, Length=270, Percent_Identity=28.1481481481481, Blast_Score=69, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17560676, Length=271, Percent_Identity=29.8892988929889, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17555706, Length=268, Percent_Identity=33.2089552238806, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17561402, Length=276, Percent_Identity=29.7101449275362, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI25147288, Length=271, Percent_Identity=31.3653136531365, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17568967, Length=238, Percent_Identity=31.0924369747899, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17544670, Length=284, Percent_Identity=26.056338028169, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI115534694, Length=267, Percent_Identity=31.0861423220974, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17562908, Length=292, Percent_Identity=29.7945205479452, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17560332, Length=277, Percent_Identity=30.6859205776173, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI193203115, Length=215, Percent_Identity=27.4418604651163, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17559104, Length=278, Percent_Identity=31.6546762589928, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17562906, Length=284, Percent_Identity=28.169014084507, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17567345, Length=213, Percent_Identity=26.2910798122066, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI71994604, Length=280, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI193203117, Length=208, Percent_Identity=28.3653846153846, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17538480, Length=281, Percent_Identity=27.0462633451957, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17562910, Length=274, Percent_Identity=27.007299270073, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17531453, Length=278, Percent_Identity=28.0575539568345, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193204405, Length=275, Percent_Identity=26.9090909090909, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17562904, Length=282, Percent_Identity=26.5957446808511, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI71982365, Length=198, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17508895, Length=213, Percent_Identity=29.1079812206573, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17564282, Length=213, Percent_Identity=27.6995305164319, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17538182, Length=282, Percent_Identity=27.3049645390071, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17538486, Length=280, Percent_Identity=28.2142857142857, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI71994600, Length=275, Percent_Identity=26.5454545454545, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17562990, Length=274, Percent_Identity=27.007299270073, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17560220, Length=282, Percent_Identity=28.0141843971631, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17558628, Length=197, Percent_Identity=29.4416243654822, Blast_Score=64, Evalue=9e-11, Organism=Caenorhabditis elegans, GI17551412, Length=284, Percent_Identity=26.056338028169, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=196, Percent_Identity=32.6530612244898, Blast_Score=89, Evalue=5e-19, Organism=Saccharomyces cerevisiae, GI6324126, Length=273, Percent_Identity=27.1062271062271, Blast_Score=75, Evalue=1e-14, Organism=Drosophila melanogaster, GI24644339, Length=269, Percent_Identity=31.9702602230483, Blast_Score=104, Evalue=5e-23, Organism=Drosophila melanogaster, GI24639444, Length=271, Percent_Identity=31.3653136531365, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI21357041, Length=272, Percent_Identity=30.8823529411765, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI28571526, Length=274, Percent_Identity=30.2919708029197, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI18859837, Length=253, Percent_Identity=31.6205533596838, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI21355319, Length=267, Percent_Identity=28.0898876404494, Blast_Score=89, Evalue=5e-18, Organism=Drosophila melanogaster, GI23397609, Length=271, Percent_Identity=31.7343173431734, Blast_Score=88, Evalue=7e-18, Organism=Drosophila melanogaster, GI24640492, Length=217, Percent_Identity=29.4930875576037, Blast_Score=86, Evalue=3e-17, Organism=Drosophila melanogaster, GI17737361, Length=218, Percent_Identity=30.2752293577982, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI21357673, Length=204, Percent_Identity=30.3921568627451, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24643142, Length=269, Percent_Identity=28.6245353159851, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI24644337, Length=181, Percent_Identity=32.0441988950276, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI281364892, Length=214, Percent_Identity=27.5700934579439, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI116007236, Length=256, Percent_Identity=25, Blast_Score=68, Evalue=8e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 28223; Mature: 28223
Theoretical pI: Translated: 4.42; Mature: 4.42
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASVPYPLSTADDLAAT CCCCCCCCCEEEEEECHHCCCCCEEEEEEECCCCEEEHHHHHHHHCCCCCCCCHHHHHHH VELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFGRLDIVVANAGIAMMQAGDDGWRDV HHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCHHHCCEEEEEECCCEEEEECCCCCCCEE IDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGL EEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHH MRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLTTADMDAPHNLGNALPVELVQPT HHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCC DIANAVAWLASEEARYVTGVTLPVDAGFVNKR HHHHHHHHHHCCCCEEEEEEEEEECCCCCCCC >Mature Secondary Structure MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASVPYPLSTADDLAAT CCCCCCCCCEEEEEECHHCCCCCEEEEEEECCCCEEEHHHHHHHHCCCCCCCCHHHHHHH VELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFGRLDIVVANAGIAMMQAGDDGWRDV HHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCHHHCCEEEEEECCCEEEEECCCCCCCEE IDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGL EEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHH MRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLTTADMDAPHNLGNALPVELVQPT HHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCC DIANAVAWLASEEARYVTGVTLPVDAGFVNKR HHHHHHHHHHCCCCEEEEEEEEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA