Click here to switch to the map view.

The map label for this gene is dxs

Identifier: 148823872

GI number: 148823872

Start: 3010007

End: 3011923

Strand: Reverse

Name: dxs

Synonym: TBFG_12697

Alternate gene names: 148823872

Gene position: 3011923-3010007 (Counterclockwise)

Preceding gene: 148823876

Following gene: 148823868

Centisome position: 68.07

GC content: 67.24

Gene sequence:

>1917_bases
ATGCTGCAACAGATCCGCGGGCCCGCTGATCTGCAGCACCTTTCCCAGGCGCAGCTTCGGGAGCTGGCCGCCGAGATCCG
TGAGTTCCTGATCCACAAGGTTGCCGCCACGGGGGGGCATCTGGGGCCGAACCTGGGAGTGGTGGAACTCACCTTGGCGC
TGCACCGGGTATTCGACTCGCCGCACGATCCGATCATCTTCGACACCGGTCACCAGGCCTACGTCCACAAGATGTTGACC
GGACGCAGCCAGGACTTCGCAACCCTGCGTAAGAAGGGCGGGTTGTCGGGGTATCCGTCTCGTGCCGAGAGCGAGCACGA
CTGGGTGGAGTCGAGCCACGCCAGCGCGGCGCTGTCGTACGCGGACGGGTTGGCCAAGGCGTTCGAGTTGACCGGACACC
GCAACCGGCATGTGGTCGCGGTGGTCGGTGACGGTGCGCTCACCGGCGGTATGTGCTGGGAGGCGCTGAACAATATCGCC
GCATCCCGCCGGCCGGTGATTATCGTGGTCAACGACAATGGGCGCAGCTACGCGCCCACAATCGGGGGCGTCGCCGACCA
TCTGGCCACGCTGCGGCTGCAGCCGGCCTACGAGCAGGCGCTGGAGACGGGCCGCGACCTGGTGCGCGCGGTGCCGCTTG
TCGGCGGTCTGTGGTTTCGATTCCTGCACAGCGTCAAGGCCGGCATCAAGGACTCGCTGTCGCCGCAGTTGCTGTTCACC
GACCTCGGGTTGAAGTACGTCGGCCCGGTCGACGGCCATGACGAGCGGGCGGTGGAGGTCGCGCTGCGCAGCGCGCGGCG
CTTCGGTGCACCGGTGATCGTGCACGTCGTCACCCGCAAGGGCATGGGCTACCCGCCGGCCGAGGCCGACCAGGCCGAGC
AGATGCATTCCACGGTCCCGATCGATCCGGCCACCGGACAAGCCACCAAGGTGGCCGGCCCAGGCTGGACGGCGACCTTC
TCTGATGCACTTATCGGCTACGCCCAGAAACGCCGTGACATCGTGGCCATTACCGCGGCCATGCCGGGCCCCACCGGGCT
GACCGCGTTCGGGCAGCGCTTCCCGGATCGATTGTTCGACGTCGGGATCGCCGAGCAACACGCGATGACGTCGGCGGCCG
GGTTGGCGATGGGTGGGCTGCACCCCGTGGTGGCGATCTACTCGACGTTCCTGAACCGGGCGTTCGACCAGATCATGATG
GATGTGGCGCTGCACAAGCTGCCGGTCACCATGGTGCTGGACCGTGCCGGGATCACCGGTAGCGACGGCGCCAGCCACAA
CGGAATGTGGGACTTGTCGATGCTGGGTATCGTGCCCGGCATCCGGGTGGCAGCGCCCAGAGACGCCACCCGGTTGCGTG
AAGAACTCGGCGAGGCGCTCGACGTCGACGACGGCCCGACGGCGTTACGGTTCCCCAAAGGTGATGTGGGAGAAGATATT
TCGGCTTTGGAGCGGCGTGGAGGCGTGGATGTGCTGGCGGCGCCCGCCGATGGTTTGAACCACGACGTCCTGTTGGTGGC
CATCGGCGCGTTCGCACCGATGGCGTTGGCGGTGGCCAAGCGGCTGCACAACCAGGGGATCGGTGTGACGGTGATCGACC
CGCGCTGGGTGTTGCCGGTGTCTGACGGTGTGCGCGAACTGGCGGTGCAGCACAAGCTGCTCGTCACGCTAGAGGACAAC
GGGGTCAACGGTGGGGCGGGGTCAGCGGTGTCGGCCGCGCTGCGGCGCGCGGAGATCGACGTGCCCTGCCGCGATGTCGG
GTTGCCGCAGGAGTTCTACGAGCACGCGTCTCGAAGCGAGGTGCTGGCCGATCTGGGGCTTACCGACCAGGACGTGGCCC
GGCGGATCACCGGCTGGGTCGCCGCGCTGGGTACCGGGGTGTGTGCGTCCGACGCGATTCCAGAACATCTCGACTAA

Upstream 100 bases:

>100_bases
TCCCGGCGCGCCGGCCACCGACGCTATCAAAGTGGTTCGGCCCTTTTGATCGGCGGCCGCATGCTGGGCCAATGGGGGGG
TTGCTGCGTACACTAGCGAA

Downstream 100 bases:

>100_bases
GAGCCATCATCGCCCTGGGCGCCGGCGTCCGGAGCCCCTGTCAACGCCGCGGTCAGGATGGGGACCACTAGTTCGAGCTG
CCAGGCCCGTGCCTGGCCGG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT
GRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSYADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIA
ASRRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFT
DLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVPIDPATGQATKVAGPGWTATF
SDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFDVGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMM
DVALHKLPVTMVLDRAGITGSDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDI
SALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPVSDGVRELAVQHKLLVTLEDN
GVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSEVLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD

Sequences:

>Translated_638_residues
MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT
GRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSYADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIA
ASRRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFT
DLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVPIDPATGQATKVAGPGWTATF
SDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFDVGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMM
DVALHKLPVTMVLDRAGITGSDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDI
SALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPVSDGVRELAVQHKLLVTLEDN
GVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSEVLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD
>Mature_638_residues
MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT
GRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSYADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIA
ASRRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFT
DLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVPIDPATGQATKVAGPGWTATF
SDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFDVGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMM
DVALHKLPVTMVLDRAGITGSDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDI
SALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPVSDGVRELAVQHKLLVTLEDN
GVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSEVLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=589, Percent_Identity=23.7691001697793, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4507521, Length=589, Percent_Identity=23.7691001697793, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI133778974, Length=306, Percent_Identity=25.8169934640523, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=39.6103896103896, Blast_Score=449, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24666278, Length=599, Percent_Identity=24.5409015025042, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_MYCBO (P0A555)

Other databases:

- EMBL:   BX248343
- RefSeq:   NP_856347.1
- ProteinModelPortal:   P0A555
- SMR:   P0A555
- EnsemblBacteria:   EBMYCT00000016648
- GeneID:   1091910
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2701c
- GeneTree:   EBGT00050000016269
- HOGENOM:   HBG571647
- OMA:   RESILRY
- ProtClustDB:   PRK05444
- BioCyc:   MBOV233413:MB2701C-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67886; Mature: 67886

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
PHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSY
CCCCEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIAASRRPVIIVVNDNGRSYAPT
HHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEECCC
IGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFT
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVP
ECCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCCCCCHHHHHHHCCCC
IDPATGQATKVAGPGWTATFSDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFD
CCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCHHHHH
VGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVLDRAGITG
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCC
SDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDI
CCCCCCCCEEEHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHH
SALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPV
HHHHHCCCCEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEH
SDGVRELAVQHKLLVTLEDNGVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSE
HHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCHHHHHCCHHHH
VLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
PHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSY
CCCCEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIAASRRPVIIVVNDNGRSYAPT
HHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEECCC
IGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFT
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVP
ECCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCCCCCHHHHHHHCCCC
IDPATGQATKVAGPGWTATFSDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFD
CCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCHHHHH
VGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVLDRAGITG
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCC
SDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDI
CCCCCCCCEEEHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHH
SALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPV
HHHHHCCCCEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEH
SDGVRELAVQHKLLVTLEDNGVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSE
HHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCHHHHHCCHHHH
VLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972