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The map label for this gene is 148823817

Identifier: 148823817

GI number: 148823817

Start: 2962910

End: 2963803

Strand: Direct

Name: 148823817

Synonym: TBFG_12642

Alternate gene names: NA

Gene position: 2962910-2963803 (Clockwise)

Preceding gene: 148823816

Following gene: 148823822

Centisome position: 66.97

GC content: 66.11

Gene sequence:

>894_bases
ATGTCATCGGGCAATTCATCTCTGGGAATTATCGTCGGGATCGACGATTCACCGGCCGCACAGGTTGCGGTGCGGTGGGC
AGCTCGGGATGCGGAGTTGCGAAAAATCCCTCTGACGCTCGTGCACGCGGTGTCGCCGGAAGTAGCCACCTGGCTGGAGG
TGCCACTGCCGCCGGGCGTGCTGCGATGGCAGCAGGATCACGGGCGCCACCTGATCGACGACGCACTCAAGGTGGTTGAA
CAGGCTTCGCTGCGCGCTGGTCCCCCCACGGTCCACAGTGAAATCGTTCCGGCGGCAGCCGTTCCCACATTGGTCGACAT
GTCCAAAGACGCAGTGCTGATGGTCGTGGGTTGTCTCGGAAGTGGGCGGTGGCCGGGCCGGCTGCTCGGTTCGGTCAGTT
CCGGCCTGCTCCGCCACGCGCACTGTCCGGTCGTGATCATCCACGACGAAGATTCGGTGATGCCGCATCCCCAGCAAGCG
CCGGTGCTAGTTGGCGTTGACGGCTCGTCGGCCTCCGAGCTGGCGACCGCAATCGCATTCGACGAAGCGTCGCGGCGAAA
CGTGGACCTGGTGGCGCTGCACGCATGGAGCGACGTCGATGTGTCGGAGTGGCCCGGAATCGATTGGCCGGCAACTCAGT
CGATGGCCGAGCAGGTGCTGGCCGAGCGGTTGGCGGGTTGGCAGGAGCGGTATCCCAACGTAGCCATAACCCGCGTGGTG
GTGCGCGATCAGCCGGCCCGCCAGCTCGTCCAACGCTCCGAGGAAGCCCAGCTGGTCGTGGTCGGCAGCCGGGGCCGCGG
CGGCTACGCCGGAATGCTGGTGGGGTCGGTAGGCGAAACCGTTGCTCAGCTGGCGCGGACGCCGGTCATCGTGGCACGCG
AGTCGCTGACTTAG

Upstream 100 bases:

>100_bases
AACGCCTCCTGAGCAAAACCCTCCTCCCCCGTTACCGTCGTGCGGTAGGGACAAGCCACATCGGCCGAGCGGGCGATCAG
CCAACGACAGGAGGACCGCG

Downstream 100 bases:

>100_bases
GTTCAGCGGCGAACGACAAGCACCGAACACTCGGCGTGACGGAACACCGGATGTCCGGATGGCCCGACCAGCCGCGCTAG
CTGACCGGCCTCACCACCGC

Product: hypothetical protein

Products: NA

Alternate protein names: USP Rv2623

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVSPEVATWLEVPLPPGVLRWQQDHGRHLIDDALKVVE
QASLRAGPPTVHSEIVPAAAVPTLVDMSKDAVLMVVGCLGSGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQA
PVLVGVDGSSASELATAIAFDEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAERLAGWQERYPNVAITRVV
VRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETVAQLARTPVIVARESLT

Sequences:

>Translated_297_residues
MSSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVSPEVATWLEVPLPPGVLRWQQDHGRHLIDDALKVVE
QASLRAGPPTVHSEIVPAAAVPTLVDMSKDAVLMVVGCLGSGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQA
PVLVGVDGSSASELATAIAFDEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAERLAGWQERYPNVAITRVV
VRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETVAQLARTPVIVARESLT
>Mature_296_residues
SSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVSPEVATWLEVPLPPGVLRWQQDHGRHLIDDALKVVEQ
ASLRAGPPTVHSEIVPAAAVPTLVDMSKDAVLMVVGCLGSGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQAP
VLVGVDGSSASELATAIAFDEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAERLAGWQERYPNVAITRVVV
RDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETVAQLARTPVIVARESLT

Specific function: May play a role in the establisment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not sho

COG id: COG0589

COG function: function code T; Universal stress protein UspA and related nucleotide-binding proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the universal stress protein A family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2623_MYCTU (O06189)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842580
- PIR:   F70572
- RefSeq:   NP_217139.1
- RefSeq:   NP_337200.1
- PDB:   2JAX
- PDB:   3CIS
- PDBsum:   2JAX
- PDBsum:   3CIS
- ProteinModelPortal:   O06189
- SMR:   O06189
- EnsemblBacteria:   EBMYCT00000000977
- EnsemblBacteria:   EBMYCT00000069550
- GeneID:   887442
- GeneID:   925608
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2698
- KEGG:   mtu:Rv2623
- TIGR:   MT2698
- TubercuList:   Rv2623
- GeneTree:   EBGT00050000015432
- HOGENOM:   HBG733992
- OMA:   QWATREA
- ProtClustDB:   CLSK791959
- GO:   GO:0005829
- GO:   GO:0040007
- GO:   GO:0009405
- InterPro:   IPR014729
- InterPro:   IPR006015
- InterPro:   IPR006016
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01438

Pfam domain/function: PF00582 Usp

EC number: NA

Molecular weight: Translated: 31652; Mature: 31521

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVSPEVATWLEVPLPPGV
CCCCCCCEEEEEECCCCCHHHEEEEEHHCCCCHHCCCEEEEECCCCCHHHEEECCCCCCC
LRWQQDHGRHLIDDALKVVEQASLRAGPPTVHSEIVPAAAVPTLVDMSKDAVLMVVGCLG
EEECHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCEEEEEEEECC
SGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQAPVLVGVDGSSASELATAIAF
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
DEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAERLAGWQERYPNVAITRVV
CCCCCCCCEEEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
VRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETVAQLARTPVIVARESLT
ECCCHHHHHHHCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCCEEEEECCCC
>Mature Secondary Structure 
SSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAVSPEVATWLEVPLPPGV
CCCCCCEEEEEECCCCCHHHEEEEEHHCCCCHHCCCEEEEECCCCCHHHEEECCCCCCC
LRWQQDHGRHLIDDALKVVEQASLRAGPPTVHSEIVPAAAVPTLVDMSKDAVLMVVGCLG
EEECHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCEEEEEEEECC
SGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQAPVLVGVDGSSASELATAIAF
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
DEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQVLAERLAGWQERYPNVAITRVV
CCCCCCCCEEEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
VRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGSVGETVAQLARTPVIVARESLT
ECCCHHHHHHHCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036