Click here to switch to the map view.

The map label for this gene is secF

Identifier: 148823781

GI number: 148823781

Start: 2926000

End: 2927328

Strand: Reverse

Name: secF

Synonym: TBFG_12606

Alternate gene names: 148823781

Gene position: 2927328-2926000 (Counterclockwise)

Preceding gene: 148823782

Following gene: 148823780

Centisome position: 66.16

GC content: 65.84

Gene sequence:

>1329_bases
ATGGCGTCGAAAGCAAAGACCGGCCGCGACGACGAAGCCACGTCGGCGGTCGAACTCACCGAGGCCACCGAGAGTGCTGT
GGCGCGGACCGACGGCGACAGCACCACAGACACCGCCTCGAAGCTGGGGCACCATAGCTTCCTTTCGCGCCTGTACACCG
GCACCGGGGCGTTTGAGGTAGTGGGACGCCGCCGGTTGTGGTTTGGCGTGAGCGGTGCGATCGTCGCGGTGGCCATCGCC
AGCATCGTCTTTCGTGGGTTCACCTTCGGCATCGATTTCAAAGGCGGTACCACGGTGTCGTTCCCGCGTGGCAGCACCCA
AGTCGCGCAGGTCGAAGACGTCTACTACCGGGCCCTCGGCAGTGAGCCCCAGTCGGTGGTGATCGTCGGGGCCGGTGCTT
CGGCGACGGTGCAGATTCGTTCGGAGACGCTGACCAGCGACCAGACGGCCAAGCTGCGGGACGCCCTATTCGAGGCCTTC
GGGCCCAAGGGAACCGACGGTCAGCCCAGCAAGCAGGCCATCAGCGACTCGGCGGTGTCGGAGACCTGGGGCGGTCAGAT
CACCAAGAAGGCGGTGATCGCGCTGGTGGTGTTTCTGGTGCTGGTCGCCCTCTACATTACCGTGCGCTACGAGCGCTACA
TGACCATCTCGGCGATAACGGCCATGCTCTTCGACCTGACCGTCACCGCCGGCGTGTATTCCCTGGTGGGTTTCGAAGTC
ACCCCGGCCACGGTCATCGGCCTGCTGACCATTCTCGGGTTCTCGCTCTATGACACCGTCATCGTGTTCGACAAGGTCGA
GGAGAACACCCATGGCTTCCAGCACACCACCCGGCGCACCTTCGCCGAGCAGGCCAACCTGGCGATCAACCAGACGTTCA
TGCGGTCGATCAACACCAGCCTGATCGGCGTGTTGCCGGTGTTGGCGCTGATGGTGGTGGCGGTCTGGCTGCTGGGCGTC
GGCACTCTCAAAGACCTGGCGCTGGTGCAGCTGATCGGCATCATCATCGGCACCTACTCGTCAATCTTCTTCGCCACGCC
GCTGTTGGTTACCCTCCGTGAGCGCACGGAGTTGGTGCGCAACCACACCCGTCGGGTGCTCAAACGGCGTAACTCCGGCT
CGCCGGCGGGATCAGAGGACGCCAGCACGGATGGCGGCGAGCAGCCGGCAGCCGCTGATGAACAGTCGCTGGTGGGGATC
ACGCAGGCCAGCAGCCAATCCGCCCCGCGGGCGGCCCAGGGCTCCAGCAAGCCGGCGCCGGGGGCGCGCCCAGTGCGTCC
CGTCGGTACCAGGCGTCCGACCGGCAAGCGGAACGCCGGTCGGCGGTAG

Upstream 100 bases:

>100_bases
ATCGTCGCTGCTGGCCAAGCCGGCATACAACGGCCTGGGAGCGGTGCAGCAGGTCGCACGCGAACGCCGGGCCATGGCTC
GGACGGGACGGGGATAGCCG

Downstream 100 bases:

>100_bases
GCGCGGTGGCCCCCCGCCGCCGGCGTCATACGCGCATCGCCGGCCTGCGAGTCGTTGGTACCGCGACGTTGGTCGCCGCA
ACCACGCTGACCGCGTGTTC

Product: preprotein translocase subunit SecF

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHHSFLSRLYTGTGAFEVVGRRRLWFGVSGAIVAVAIA
SIVFRGFTFGIDFKGGTTVSFPRGSTQVAQVEDVYYRALGSEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAF
GPKGTDGQPSKQAISDSAVSETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAMLFDLTVTAGVYSLVGFEV
TPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTSLIGVLPVLALMVVAVWLLGV
GTLKDLALVQLIGIIIGTYSSIFFATPLLVTLRERTELVRNHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVGI
TQASSQSAPRAAQGSSKPAPGARPVRPVGTRRPTGKRNAGRR

Sequences:

>Translated_442_residues
MASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHHSFLSRLYTGTGAFEVVGRRRLWFGVSGAIVAVAIA
SIVFRGFTFGIDFKGGTTVSFPRGSTQVAQVEDVYYRALGSEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAF
GPKGTDGQPSKQAISDSAVSETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAMLFDLTVTAGVYSLVGFEV
TPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTSLIGVLPVLALMVVAVWLLGV
GTLKDLALVQLIGIIIGTYSSIFFATPLLVTLRERTELVRNHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVGI
TQASSQSAPRAAQGSSKPAPGARPVRPVGTRRPTGKRNAGRR
>Mature_441_residues
ASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHHSFLSRLYTGTGAFEVVGRRRLWFGVSGAIVAVAIAS
IVFRGFTFGIDFKGGTTVSFPRGSTQVAQVEDVYYRALGSEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAFG
PKGTDGQPSKQAISDSAVSETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAMLFDLTVTAGVYSLVGFEVT
PATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTSLIGVLPVLALMVVAVWLLGVG
TLKDLALVQLIGIIIGTYSSIFFATPLLVTLRERTELVRNHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVGIT
QASSQSAPRAAQGSSKPAPGARPVRPVGTRRPTGKRNAGRR

Specific function: Involved in protein export

COG id: COG0341

COG function: function code U; Preprotein translocase subunit SecF

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secD/secF family. SecF subfamily

Homologues:

Organism=Escherichia coli, GI1786610, Length=297, Percent_Identity=26.9360269360269, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECF_MYCTU (Q50635)

Other databases:

- EMBL:   BX842580
- EMBL:   AE000516
- PIR:   A70726
- RefSeq:   NP_217102.1
- RefSeq:   NP_337162.1
- ProteinModelPortal:   Q50635
- EnsemblBacteria:   EBMYCT00000001894
- EnsemblBacteria:   EBMYCT00000070591
- GeneID:   887229
- GeneID:   925652
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2663
- KEGG:   mtu:Rv2586c
- TIGR:   MT2663
- TubercuList:   Rv2586c
- GeneTree:   EBGT00050000016758
- HOGENOM:   HBG465293
- OMA:   MVRMPPV
- ProtClustDB:   PRK13022
- InterPro:   IPR022813
- InterPro:   IPR022646
- InterPro:   IPR022645
- InterPro:   IPR005665
- PRINTS:   PR01755
- TIGRFAMs:   TIGR00916
- TIGRFAMs:   TIGR00966

Pfam domain/function: PF07549 Sec_GG; PF02355 SecD_SecF

EC number: NA

Molecular weight: Translated: 47014; Mature: 46883

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x173aaf54)-; HASH(0x1c3b5238)-; HASH(0x197a89d4)-; HASH(0x1c20ba28)-; HASH(0x1c3c2050)-; HASH(0x1c7a1cd0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHHSFLSRLYTGTGAFEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
VGRRRLWFGVSGAIVAVAIASIVFRGFTFGIDFKGGTTVSFPRGSTQVAQVEDVYYRALG
HCCHHEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCCHHHHHHHHHHHHHC
SEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAFGPKGTDGQPSKQAISDSAVS
CCCCEEEEEECCCCEEEEEECHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
ETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAMLFDLTVTAGVYSLVGFEV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTS
CHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
LIGVLPVLALMVVAVWLLGVGTLKDLALVQLIGIIIGTYSSIFFATPLLVTLRERTELVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVGITQASSQSAPRAAQGSSKPAP
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCC
GARPVRPVGTRRPTGKRNAGRR
CCCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
ASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHHSFLSRLYTGTGAFEV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
VGRRRLWFGVSGAIVAVAIASIVFRGFTFGIDFKGGTTVSFPRGSTQVAQVEDVYYRALG
HCCHHEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCCHHHHHHHHHHHHHC
SEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAFGPKGTDGQPSKQAISDSAVS
CCCCEEEEEECCCCEEEEEECHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
ETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAMLFDLTVTAGVYSLVGFEV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTS
CHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
LIGVLPVLALMVVAVWLLGVGTLKDLALVQLIGIIIGTYSSIFFATPLLVTLRERTELVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVGITQASSQSAPRAAQGSSKPAP
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCC
GARPVRPVGTRRPTGKRNAGRR
CCCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036